Beta-Amyloid (Aβ<sub>1-42</sub>) Increases the Expression of NKCC1 in the Mouse Hippocampus

Beta-Amyloid (Aβ<sub>1-42</sub>) Increases the Expression of NKCC1 in the Mouse Hippocampus

Alzheimer’s disease (AD) is a neurodegenerative disorder with an increasing need for developing disease-modifying treatments as current therapies only provide marginal symptomatic relief. Recent evidence suggests the γ-aminobutyric acid (GABA) neurotransmitter system undergoes remodeling in AD, disr...

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Bibliographic Details
Main Authors: Patricia Lam, Chitra Vinnakota, Beatriz Calvo-Flores Guzmán, Julia Newland, Katie Peppercorn, Warren P. Tate, Henry J. Waldvogel, Richard L. M. Faull, Andrea Kwakowsky
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Molecules
Subjects:
Alzheimer’s disease
GABA
beta amyloid
KCC2
NKCC1
bumetanide
Online Access:https://www.mdpi.com/1420-3049/27/8/2440

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