Suppression of Proliferation of Human Glioblastoma Cells by Combined Phosphodiesterase and Multidrug Resistance-Associated Protein 1 Inhibition

Suppression of Proliferation of Human Glioblastoma Cells by Combined Phosphodiesterase and Multidrug Resistance-Associated Protein 1 Inhibition

The paucity of currently available therapies for glioblastoma multiforme requires novel approaches to the treatment of this brain tumour. Disrupting cyclic nucleotide-signalling through phosphodiesterase (PDE) inhibition may be a promising way of suppressing glioblastoma growth. Here, we examined th...

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Bibliographic Details
Main Authors: Liliya Kopanitsa, Maksym V. Kopanitsa, Dewi Safitri, Graham Ladds, David S. Bailey
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:International Journal of Molecular Sciences
Subjects:
glioblastoma
drug combination
multidrug resistance-associated protein 1
phosphodiesterase inhibitor
proliferation
Online Access:https://www.mdpi.com/1422-0067/22/18/9665

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