Enhancement of Anticancer Effects by Combining 5-Fluorouracil with Refametinib in Human Oral Squamous Cell Carcinoma Cell Line

Enhancement of Anticancer Effects by Combining 5-Fluorouracil with Refametinib in Human Oral Squamous Cell Carcinoma Cell Line

(1) Background: Oral squamous cell carcinoma (OSCC) is a significant health burden worldwide. This study aimed to determine the potentials of Refametinib, an orally bioavailable selective MEK1/2 inhibitor, to increase the effectiveness of 5-Fluorouracil (5-FU), a common cytotoxic drug, in the SCC4 c...

Full description

Bibliographic Details
Main Authors:	Po-Chun Chen, Bor-Chyuan Su, Tien-Li Ma, Ying Chui Hong, Yu-Wen Chen, Thi Thuy Tien Vo, Luo-Yun Wu, Tzu-Yu Peng, Ching-Shuen Wang, I-Ta Lee
Format:	Article
Language:	English
Published:	MDPI AG 2023-03-01
Series:	Applied Sciences
Subjects:	5-fluorouracil apoptosis extracellular signal-related kinase MEK inhibitor oral squamous cell carcinoma programmed death-ligand 1
Online Access:	https://www.mdpi.com/2076-3417/13/7/4340

Similar Items

Sanguisorba officinalis L. enhances the 5-fluorouracil sensitivity and overcomes chemoresistance in 5-fluorouracil-resistant colorectal cancer cells via Ras/MEK/ERK and PI3K/Akt pathways
by: Weijia Zhang, et al.
Published: (2023-06-01)

Prolonged exposure of colon cancer cells to 5-fluorouracil nanoparticles improves its anticancer activity
by: Essam Tawfik, et al.
Published: (2017-02-01)

Mitomycin and 5‐fluorouracil for second‐line treatment of metastatic squamous cell carcinomas of the anal canal
by: Angélique Saint, et al.
Published: (2019-11-01)

Matairesinol Induces Mitochondrial Dysfunction and Exerts Synergistic Anticancer Effects with 5-Fluorouracil in Pancreatic Cancer Cells
by: Woonghee Lee, et al.
Published: (2022-07-01)

The role of NLRP3 inflammasome in 5-fluorouracil resistance of oral squamous cell carcinoma
by: Xiaodong Feng, et al.
Published: (2017-06-01)

In Vitro Antioxidant and Pancreatic Anticancer Activity of Novel 5-Fluorouracil-Coumarin Conjugates
by: Sonia López, et al.
Published: (2022-10-01)

Delirium and seizures in a patient with head-and-neck squamous cell carcinoma on docetaxel, cisplatin, and 5-fluorouracil
by: Satvik Khaddar, et al.
Published: (2019-01-01)

Complexed Crystal Structure of the Dihydroorotase Domain of Human CAD Protein with the Anticancer Drug 5-Fluorouracil
by: En-Shyh Lin, et al.
Published: (2023-01-01)

Cardiotoxicity of 5-fluorouracil and capecitabine in Chinese patients: a prospective study
by: Jianjun Peng, et al.
Published: (2018-05-01)

Tetrathiomolybdate sensitizes ovarian cancer cells to anticancer drugs doxorubicin, fenretinide, 5-fluorouracil and mitomycin C
by: Kim Kyu Kwang, et al.
Published: (2012-04-01)

Cadmium influences the 5-Fluorouracil cytotoxic effects on breast cancer cells
by: Y. Asara, et al.
Published: (2012-01-01)

Specifics of Pharmacokinetics and Biodistribution of 5-Fluorouracil Polymeric Complex
by: Olga V. Zhukova, et al.
Published: (2023-12-01)

Clinical observation of needle revision and 5-fluorouracil subconjunctive injection for the dysfunctional filtering blebs
by: Yan-Hua Gao, et al.
Published: (2016-07-01)

Electrochemical Assessment of Anticancer Compounds on the Human Tongue Squamous Carcinoma Cells
by: Chun-Chung Huang, et al.
Published: (2020-05-01)

In Vitro Evaluation of Sulforaphane and a Natural Analog as Potent Inducers of 5-Fluorouracil Anticancer Activity
by: Małgorzata Milczarek, et al.
Published: (2018-11-01)

Corneal Epithelial Hyperplasia after 5-Fluorouracil Injection
by: Dania A. Bukhari, et al.
Published: (2018-04-01)

Binding Pattern and Structural Interactome of the Anticancer Drug 5-Fluorouracil: A Critical Review
by: En-Shyh Lin, et al.
Published: (2024-03-01)

Synthesis and Bioevaluation of 5-Fluorouracil Derivatives
by: Chao-Jie Wang, et al.
Published: (2007-11-01)

Enhancing the anticancer effects of 5-fluorouracil: Current challenges and future perspectives
by: François Ghiringhelli, et al.
Published: (2015-04-01)

Sequential treatment with ursolic acid chlorophenyl triazole followed by 5-fluorouracil shows synergistic activity in small cell lung cancer cells
by: Rui-Xia Zhu, et al.
Published: (2015-03-01)

Clinical Efficacy of 5-Fluorouracil and Bleomycin in Dermatology
by: Suyeon Kim, et al.
Published: (2024-01-01)

Synthesis, biological evaluation and docking studies of 1,2,4-oxadiazole linked 5-fluorouracil derivatives as anticancer agents
by: Ravi Kumar Bommera, et al.
Published: (2021-05-01)

Combined Effect of 5-Fluorouracil and Acriflavine on Mortality Rate of Colorectal Cancer Cell Lines
by: Parsa Zargar, et al.
Published: (2016-06-01)

Outcomes of Trabeculectomy with 5-Fluorouracil at a Nigerian Tertiary Hospital
by: Olusola O Olawoye, et al.
Published: (2013-01-01)

Autophagy Inhibitor (LY294002) and 5-fluorouracil (5-FU) Combination-Based Nanoliposome for Enhanced Efficacy Against Esophageal Squamous Cell Carcinoma
by: Ye Feng, et al.
Published: (2018-10-01)

Definitive chemoradiotherapy with low-dose continuous 5-fluorouracil reduces hematological toxicity without compromising survival in esophageal squamous cell carcinoma patients
by: Hirotake Saito, et al.
Published: (2018-02-01)

A patient with squamous cell carcinoma in-situ successfully treated with intralesional 5-Fluorouracil and topical trichloroacetic acid
by: Thomas Vazquez, et al.
Published: (2020-02-01)

Combination of Oxaliplatin and 5-Fluorouracil/Leucovorin for Advanced Esophageal Squamous Cell Carcinoma Refractory or Intolerant to Standard Therapies
by: Seiichiro Mitani, et al.
Published: (2019-04-01)

Endoscopic study of the intranasal ostium in external dacryocystorhinostomy postoperative. Influence of saline solution and 5-fluorouracil Estudo endoscópico do óstio intranasal no pós-operatório de dacriocistorrinostomia externa e influência do uso de solução salina e de 5 fluorouracil
by: Marilisa Nano Costa, et al.
Published: (2007-02-01)

Bitter melon derived extracellular vesicles enhance the therapeutic effects and reduce the drug resistance of 5-fluorouracil on oral squamous cell carcinoma
by: Meng Yang, et al.
Published: (2021-08-01)

Novel Strategies to Improve the Anticancer Action of 5-Fluorouracil by Using Drug Delivery Systems
by: JosÃƒÂ© L. Arias
Published: (2008-10-01)

In silico design and evaluation of novel 5-fluorouracil analogues as potential anticancer agents
by: Surid Mohammad Chowdhury, et al.
Published: (2020-09-01)

Investigating the Release of Methotrexate and 5-Fluorouracil Anticancer Drugs from Multi-Layered Nanofiber Structure of Polycaprolactone/Chitosan
by: N. Poursharifi, et al.
Published: (2020-01-01)

Intraoperative infiltration against topical application of 5-fluorouracil in pterygium treatment
by: Basem M Ibrahim, et al.
Published: (2017-01-01)

6-Shogaol enhances the anticancer effect of 5-fluorouracil, oxaliplatin, and irinotecan via increase of apoptosis and autophagy in colon cancer cells in hypoxic/aglycemic conditions
by: Marta Woźniak, et al.
Published: (2020-05-01)

Effects of plasma concentrations of 5-fluorouracil on long-term survival after treatment with a definitive 5-fluorouracil/cisplatin-based chemoradiotherapy in Japanese patients with esophageal squamous cell carcinoma
by: Nishiguchi Kohshi, et al.
Published: (2011-10-01)

A Pre-Clinical Study of Sub-Anesthetic Ketamine as Remedy in 5-Fluorouracil-Induced Cachexia Model
by: James Wang, et al.
Published: (2022-12-01)

Metformin Enhancement of Therapeutic Effects of 5-Fluorouracil and Oxaliplatin in Colon Cancer Cells and Nude Mice
by: Kwan-Ling Yip, et al.
Published: (2022-04-01)

Preparation of 5-fluorouracil-loaded chitosan nanoparticles and study of the sustained release in vitro and in vivo
by: Li Sun, et al.
Published: (2017-09-01)

The Preliminary Results of Pullulan Nanoparticles Loaded with 5-Fluorouracil
by: Fawzia Sha’at, et al.
Published: (2020-11-01)