Synthesis, Identification, Theoretical Study, and Effect of the New Heterocyclic System from Ciprofloxacin Derivatives on the Activity of Some Liver Enzymes
The target of this study was to synthesize several new Ciprofloxacin drug analogs by providing a nucleophilic substitution procedure that provides new functionality at the carboxylic group location. The analogs were synthesized, designed, and characterized by 1HNMR, and FTIR. The synthetic path beg...
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| Format: | Article |
| Language: | Arabic |
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College of Science for Women, University of Baghdad
2022-12-01
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| Series: | Baghdad Science Journal |
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| Online Access: | https://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/7502 |
| _version_ | 1811204855469965312 |
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| author | Amaal S. Sadiq Zahraa T. Khudhair Selvana A. Yousif Wasan A. R. Mahmood |
| author_facet | Amaal S. Sadiq Zahraa T. Khudhair Selvana A. Yousif Wasan A. R. Mahmood |
| author_sort | Amaal S. Sadiq |
| collection | DOAJ |
| description |
The target of this study was to synthesize several new Ciprofloxacin drug analogs by providing a nucleophilic substitution procedure that provides new functionality at the carboxylic group location. The analogs were synthesized, designed, and characterized by 1HNMR, and FTIR. The synthetic path began from the reaction of ciprofloxacin drug with morpholine to give compound[B], ciprofloxacin derivative was linked with a variety of primary and secondary amines to give compounds[B1-B9]. The above-mentioned prepared compounds [B3 and B5] were applied to liver enzymes, and the increase in the activity of these enzymes was observed. In addition, a theoretical study was conducted to study the energies and properties of the prepared compounds.
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| first_indexed | 2024-04-12T03:20:41Z |
| format | Article |
| id | doaj.art-617e08e5712a4159b9dcfeb9d4154a22 |
| institution | Directory Open Access Journal |
| issn | 2078-8665 2411-7986 |
| language | Arabic |
| last_indexed | 2024-04-12T03:20:41Z |
| publishDate | 2022-12-01 |
| publisher | College of Science for Women, University of Baghdad |
| record_format | Article |
| series | Baghdad Science Journal |
| spelling | doaj.art-617e08e5712a4159b9dcfeb9d4154a222022-12-22T03:49:55ZaraCollege of Science for Women, University of BaghdadBaghdad Science Journal2078-86652411-79862022-12-01196(Suppl.)10.21123/bsj.2022.7502Synthesis, Identification, Theoretical Study, and Effect of the New Heterocyclic System from Ciprofloxacin Derivatives on the Activity of Some Liver EnzymesAmaal S. Sadiq0Zahraa T. Khudhair1Selvana A. Yousif2Wasan A. R. Mahmood3Department of Chemistry, College of Science for Woman, University of Baghdad, Baghdad, IraqNational Center Teaching Laboratories, Medical City Complex in BaghdadDepartment of Chemistry, College of Science for Woman, University of Baghdad, Baghdad, IraqDepartment of Chemistry, College of Science for Woman, University of Baghdad, Baghdad, Iraq The target of this study was to synthesize several new Ciprofloxacin drug analogs by providing a nucleophilic substitution procedure that provides new functionality at the carboxylic group location. The analogs were synthesized, designed, and characterized by 1HNMR, and FTIR. The synthetic path began from the reaction of ciprofloxacin drug with morpholine to give compound[B], ciprofloxacin derivative was linked with a variety of primary and secondary amines to give compounds[B1-B9]. The above-mentioned prepared compounds [B3 and B5] were applied to liver enzymes, and the increase in the activity of these enzymes was observed. In addition, a theoretical study was conducted to study the energies and properties of the prepared compounds. https://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/7502Ciprofloxacin, Liver enzymes, Mannich reactions, Spectrum, Synthesis |
| spellingShingle | Amaal S. Sadiq Zahraa T. Khudhair Selvana A. Yousif Wasan A. R. Mahmood Synthesis, Identification, Theoretical Study, and Effect of the New Heterocyclic System from Ciprofloxacin Derivatives on the Activity of Some Liver Enzymes Baghdad Science Journal Ciprofloxacin, Liver enzymes, Mannich reactions, Spectrum, Synthesis |
| title | Synthesis, Identification, Theoretical Study, and Effect of the New Heterocyclic System from Ciprofloxacin Derivatives on the Activity of Some Liver Enzymes |
| title_full | Synthesis, Identification, Theoretical Study, and Effect of the New Heterocyclic System from Ciprofloxacin Derivatives on the Activity of Some Liver Enzymes |
| title_fullStr | Synthesis, Identification, Theoretical Study, and Effect of the New Heterocyclic System from Ciprofloxacin Derivatives on the Activity of Some Liver Enzymes |
| title_full_unstemmed | Synthesis, Identification, Theoretical Study, and Effect of the New Heterocyclic System from Ciprofloxacin Derivatives on the Activity of Some Liver Enzymes |
| title_short | Synthesis, Identification, Theoretical Study, and Effect of the New Heterocyclic System from Ciprofloxacin Derivatives on the Activity of Some Liver Enzymes |
| title_sort | synthesis identification theoretical study and effect of the new heterocyclic system from ciprofloxacin derivatives on the activity of some liver enzymes |
| topic | Ciprofloxacin, Liver enzymes, Mannich reactions, Spectrum, Synthesis |
| url | https://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/7502 |
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