The Effect of Microbubble-Assisted Ultrasound on Molecular Permeability across Cell Barriers

The Effect of Microbubble-Assisted Ultrasound on Molecular Permeability across Cell Barriers

The combination of ultrasound and microbubbles (USMB) has been applied to enhance drug permeability across tissue barriers. Most studies focused on only one physicochemical aspect (i.e., molecular weight of the delivered molecule). Using an in vitro epithelial (MDCK II) cell barrier, we examined the...

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Bibliographic Details
Main Authors: Charis Rousou, Josanne de Maar, Boning Qiu, Kim van der Wurff-Jacobs, Marika Ruponen, Arto Urtti, Sabrina Oliveira, Chrit Moonen, Gert Storm, Enrico Mastrobattista, Roel Deckers
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Pharmaceutics
Subjects:
ultrasound
microbubbles
epithelial permeation
paracellular permeability
intracellular accumulation
nanobody
Online Access:https://www.mdpi.com/1999-4923/14/3/494

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