Non-homogenous axonal bouton distribution in whole-brain single-cell neuronal networks
Summary: We examined the distribution of pre-synaptic contacts in axons of mouse neurons and constructed whole-brain single-cell neuronal networks using an extensive dataset of 1,891 fully reconstructed neurons. We found that bouton locations were not homogeneous throughout the axon and among brain...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-03-01
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| Series: | Cell Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124724001992 |
| _version_ | 1797271390148100096 |
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| author | Penghao Qian Linus Manubens-Gil Shengdian Jiang Hanchuan Peng |
| author_facet | Penghao Qian Linus Manubens-Gil Shengdian Jiang Hanchuan Peng |
| author_sort | Penghao Qian |
| collection | DOAJ |
| description | Summary: We examined the distribution of pre-synaptic contacts in axons of mouse neurons and constructed whole-brain single-cell neuronal networks using an extensive dataset of 1,891 fully reconstructed neurons. We found that bouton locations were not homogeneous throughout the axon and among brain regions. As our algorithm was able to generate whole-brain single-cell connectivity matrices from full morphology reconstruction datasets, we further found that non-homogeneous bouton locations have a significant impact on network wiring, including degree distribution, triad census, and community structure. By perturbing neuronal morphology, we further explored the link between anatomical details and network topology. In our in silico exploration, we found that dendritic and axonal tree span would have the greatest impact on network wiring, followed by synaptic contact deletion. Our results suggest that neuroanatomical details must be carefully addressed in studies of whole-brain networks at the single-cell level. |
| first_indexed | 2024-03-07T14:02:03Z |
| format | Article |
| id | doaj.art-617e2d11a23f471291ef08a7cdd551d7 |
| institution | Directory Open Access Journal |
| issn | 2211-1247 |
| language | English |
| last_indexed | 2024-03-07T14:02:03Z |
| publishDate | 2024-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj.art-617e2d11a23f471291ef08a7cdd551d72024-03-07T05:27:22ZengElsevierCell Reports2211-12472024-03-01433113871Non-homogenous axonal bouton distribution in whole-brain single-cell neuronal networksPenghao Qian0Linus Manubens-Gil1Shengdian Jiang2Hanchuan Peng3New Cornerstone Science Laboratory, SEU-ALLEN Joint Center, State Key Laboratory of Digital Medical Engineering, Institute for Brain and Intelligence, Southeast University, Nanjing, Jiangsu 210096, China; School of Computer Science and Engineering, Southeast University, Nanjing, Jiangsu 210096, ChinaNew Cornerstone Science Laboratory, SEU-ALLEN Joint Center, State Key Laboratory of Digital Medical Engineering, Institute for Brain and Intelligence, Southeast University, Nanjing, Jiangsu 210096, China; Corresponding authorNew Cornerstone Science Laboratory, SEU-ALLEN Joint Center, State Key Laboratory of Digital Medical Engineering, Institute for Brain and Intelligence, Southeast University, Nanjing, Jiangsu 210096, China; School of Computer Science and Engineering, Southeast University, Nanjing, Jiangsu 210096, ChinaNew Cornerstone Science Laboratory, SEU-ALLEN Joint Center, State Key Laboratory of Digital Medical Engineering, Institute for Brain and Intelligence, Southeast University, Nanjing, Jiangsu 210096, China; Corresponding authorSummary: We examined the distribution of pre-synaptic contacts in axons of mouse neurons and constructed whole-brain single-cell neuronal networks using an extensive dataset of 1,891 fully reconstructed neurons. We found that bouton locations were not homogeneous throughout the axon and among brain regions. As our algorithm was able to generate whole-brain single-cell connectivity matrices from full morphology reconstruction datasets, we further found that non-homogeneous bouton locations have a significant impact on network wiring, including degree distribution, triad census, and community structure. By perturbing neuronal morphology, we further explored the link between anatomical details and network topology. In our in silico exploration, we found that dendritic and axonal tree span would have the greatest impact on network wiring, followed by synaptic contact deletion. Our results suggest that neuroanatomical details must be carefully addressed in studies of whole-brain networks at the single-cell level.http://www.sciencedirect.com/science/article/pii/S2211124724001992CP: Neuroscience |
| spellingShingle | Penghao Qian Linus Manubens-Gil Shengdian Jiang Hanchuan Peng Non-homogenous axonal bouton distribution in whole-brain single-cell neuronal networks Cell Reports CP: Neuroscience |
| title | Non-homogenous axonal bouton distribution in whole-brain single-cell neuronal networks |
| title_full | Non-homogenous axonal bouton distribution in whole-brain single-cell neuronal networks |
| title_fullStr | Non-homogenous axonal bouton distribution in whole-brain single-cell neuronal networks |
| title_full_unstemmed | Non-homogenous axonal bouton distribution in whole-brain single-cell neuronal networks |
| title_short | Non-homogenous axonal bouton distribution in whole-brain single-cell neuronal networks |
| title_sort | non homogenous axonal bouton distribution in whole brain single cell neuronal networks |
| topic | CP: Neuroscience |
| url | http://www.sciencedirect.com/science/article/pii/S2211124724001992 |
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