A Comparative Evaluation of Multiparametric Magnetic Resonance Imaging and Micro-Ultrasound for the Detection of Clinically Significant Prostate Cancer in Patients with Prior Negative Biopsies
Background: The diagnostic process for prostate cancer after a negative biopsy is challenging. This study compares the diagnostic accuracy of micro-ultrasound (mUS) with multiparametric magnetic resonance imaging (mpMRI) for such cases. Methods: A retrospective cohort study was performed, targeting...
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MDPI AG
2024-03-01
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| Online Access: | https://www.mdpi.com/2075-4418/14/5/525 |
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| author | Edoardo Beatrici Nicola Frego Giuseppe Chiarelli Federica Sordelli Stefano Mancon Cesare Saitta Fabio De Carne Giuseppe Garofano Paola Arena Pier Paolo Avolio Andrea Gobbo Alessandro Uleri Roberto Contieri Marco Paciotti Massimo Lazzeri Rodolfo Hurle Paolo Casale Nicolò Maria Buffi Giovanni Lughezzani |
| author_facet | Edoardo Beatrici Nicola Frego Giuseppe Chiarelli Federica Sordelli Stefano Mancon Cesare Saitta Fabio De Carne Giuseppe Garofano Paola Arena Pier Paolo Avolio Andrea Gobbo Alessandro Uleri Roberto Contieri Marco Paciotti Massimo Lazzeri Rodolfo Hurle Paolo Casale Nicolò Maria Buffi Giovanni Lughezzani |
| author_sort | Edoardo Beatrici |
| collection | DOAJ |
| description | Background: The diagnostic process for prostate cancer after a negative biopsy is challenging. This study compares the diagnostic accuracy of micro-ultrasound (mUS) with multiparametric magnetic resonance imaging (mpMRI) for such cases. Methods: A retrospective cohort study was performed, targeting men with previous negative biopsies and using mUS and mpMRI to detect prostate cancer and clinically significant prostate cancer (csPCa). Results: In our cohort of 1397 men, 304 had a history of negative biopsies. mUS was more sensitive than mpMRI, with better predictive value for negative results. Importantly, mUS was significantly associated with csPCa detection (adjusted odds ratio [aOR]: 6.58; 95% confidence interval [CI]: 1.15–37.8; <i>p</i> = 0.035). Conclusions: mUS may be preferable for diagnosing prostate cancer in previously biopsy-negative patients. However, the retrospective design of this study at a single institution suggests that further research across multiple centers is warranted. |
| first_indexed | 2024-04-25T00:32:09Z |
| format | Article |
| id | doaj.art-6181bdb0f47a4943b30bea9585c81dfa |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-04-25T00:32:09Z |
| publishDate | 2024-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-6181bdb0f47a4943b30bea9585c81dfa2024-03-12T16:42:03ZengMDPI AGDiagnostics2075-44182024-03-0114552510.3390/diagnostics14050525A Comparative Evaluation of Multiparametric Magnetic Resonance Imaging and Micro-Ultrasound for the Detection of Clinically Significant Prostate Cancer in Patients with Prior Negative BiopsiesEdoardo Beatrici0Nicola Frego1Giuseppe Chiarelli2Federica Sordelli3Stefano Mancon4Cesare Saitta5Fabio De Carne6Giuseppe Garofano7Paola Arena8Pier Paolo Avolio9Andrea Gobbo10Alessandro Uleri11Roberto Contieri12Marco Paciotti13Massimo Lazzeri14Rodolfo Hurle15Paolo Casale16Nicolò Maria Buffi17Giovanni Lughezzani18Department of Biomedical Sciences, Humanitas University, 20072 Pieve Emanuele, MI, ItalyDepartment of Biomedical Sciences, Humanitas University, 20072 Pieve Emanuele, MI, ItalyDepartment of Biomedical Sciences, Humanitas University, 20072 Pieve Emanuele, MI, ItalyDepartment of Biomedical Sciences, Humanitas University, 20072 Pieve Emanuele, MI, ItalyDepartment of Biomedical Sciences, Humanitas University, 20072 Pieve Emanuele, MI, ItalyDepartment of Biomedical Sciences, Humanitas University, 20072 Pieve Emanuele, MI, ItalyDepartment of Biomedical Sciences, Humanitas University, 20072 Pieve Emanuele, MI, ItalyDepartment of Biomedical Sciences, Humanitas University, 20072 Pieve Emanuele, MI, ItalyDepartment of Biomedical Sciences, Humanitas University, 20072 Pieve Emanuele, MI, ItalyDepartment of Biomedical Sciences, Humanitas University, 20072 Pieve Emanuele, MI, ItalyDepartment of Biomedical Sciences, Humanitas University, 20072 Pieve Emanuele, MI, ItalyDepartment of Biomedical Sciences, Humanitas University, 20072 Pieve Emanuele, MI, ItalyDepartment of Biomedical Sciences, Humanitas University, 20072 Pieve Emanuele, MI, ItalyDepartment of Urology, IRCCS Humanitas Research Hospital, 20089 Rozzano, MI, ItalyDepartment of Urology, IRCCS Humanitas Research Hospital, 20089 Rozzano, MI, ItalyDepartment of Urology, IRCCS Humanitas Research Hospital, 20089 Rozzano, MI, ItalyDepartment of Urology, IRCCS Humanitas Research Hospital, 20089 Rozzano, MI, ItalyDepartment of Biomedical Sciences, Humanitas University, 20072 Pieve Emanuele, MI, ItalyDepartment of Biomedical Sciences, Humanitas University, 20072 Pieve Emanuele, MI, ItalyBackground: The diagnostic process for prostate cancer after a negative biopsy is challenging. This study compares the diagnostic accuracy of micro-ultrasound (mUS) with multiparametric magnetic resonance imaging (mpMRI) for such cases. Methods: A retrospective cohort study was performed, targeting men with previous negative biopsies and using mUS and mpMRI to detect prostate cancer and clinically significant prostate cancer (csPCa). Results: In our cohort of 1397 men, 304 had a history of negative biopsies. mUS was more sensitive than mpMRI, with better predictive value for negative results. Importantly, mUS was significantly associated with csPCa detection (adjusted odds ratio [aOR]: 6.58; 95% confidence interval [CI]: 1.15–37.8; <i>p</i> = 0.035). Conclusions: mUS may be preferable for diagnosing prostate cancer in previously biopsy-negative patients. However, the retrospective design of this study at a single institution suggests that further research across multiple centers is warranted.https://www.mdpi.com/2075-4418/14/5/525diagnosisimagingmicro-ultrasoundmultiparametric MRIprostate cancerprostate biopsy |
| spellingShingle | Edoardo Beatrici Nicola Frego Giuseppe Chiarelli Federica Sordelli Stefano Mancon Cesare Saitta Fabio De Carne Giuseppe Garofano Paola Arena Pier Paolo Avolio Andrea Gobbo Alessandro Uleri Roberto Contieri Marco Paciotti Massimo Lazzeri Rodolfo Hurle Paolo Casale Nicolò Maria Buffi Giovanni Lughezzani A Comparative Evaluation of Multiparametric Magnetic Resonance Imaging and Micro-Ultrasound for the Detection of Clinically Significant Prostate Cancer in Patients with Prior Negative Biopsies Diagnostics diagnosis imaging micro-ultrasound multiparametric MRI prostate cancer prostate biopsy |
| title | A Comparative Evaluation of Multiparametric Magnetic Resonance Imaging and Micro-Ultrasound for the Detection of Clinically Significant Prostate Cancer in Patients with Prior Negative Biopsies |
| title_full | A Comparative Evaluation of Multiparametric Magnetic Resonance Imaging and Micro-Ultrasound for the Detection of Clinically Significant Prostate Cancer in Patients with Prior Negative Biopsies |
| title_fullStr | A Comparative Evaluation of Multiparametric Magnetic Resonance Imaging and Micro-Ultrasound for the Detection of Clinically Significant Prostate Cancer in Patients with Prior Negative Biopsies |
| title_full_unstemmed | A Comparative Evaluation of Multiparametric Magnetic Resonance Imaging and Micro-Ultrasound for the Detection of Clinically Significant Prostate Cancer in Patients with Prior Negative Biopsies |
| title_short | A Comparative Evaluation of Multiparametric Magnetic Resonance Imaging and Micro-Ultrasound for the Detection of Clinically Significant Prostate Cancer in Patients with Prior Negative Biopsies |
| title_sort | comparative evaluation of multiparametric magnetic resonance imaging and micro ultrasound for the detection of clinically significant prostate cancer in patients with prior negative biopsies |
| topic | diagnosis imaging micro-ultrasound multiparametric MRI prostate cancer prostate biopsy |
| url | https://www.mdpi.com/2075-4418/14/5/525 |
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