Serotonergic psychedelic drugs LSD and psilocybin reduce the hierarchical differentiation of unimodal and transmodal cortex

Serotonergic psychedelic drugs LSD and psilocybin reduce the hierarchical differentiation of unimodal and transmodal cortex

Lysergic acid diethylamide (LSD) and psilocybin are serotonergic psychedelic compounds with potential in the treatment of mental health disorders. Past neuroimaging investigations have revealed that both compounds can elicit significant changes to whole-brain functional organization and dynamics. A...

Full description

Bibliographic Details
Main Authors:	Manesh Girn, Leor Roseman, Boris Bernhardt, Jonathan Smallwood, Robin Carhart-Harris, R. Nathan Spreng
Format:	Article
Language:	English
Published:	Elsevier 2022-08-01
Series:	NeuroImage
Online Access:	http://www.sciencedirect.com/science/article/pii/S1053811922003445

Similar Items

Serotonergic psychedelics LSD & psilocybin increase the fractal dimension of cortical brain activity in spatial and temporal domains
by: Thomas F. Varley, et al.
Published: (2020-10-01)

Psychedelic-induced mystical experiences: An interdisciplinary discussion and critique
by: Sharday Mosurinjohn, et al.
Published: (2023-04-01)

Quality of Acute Psychedelic Experience Predicts Therapeutic Efficacy of Psilocybin for Treatment-Resistant Depression
by: Leor Roseman, et al.
Published: (2018-01-01)

Human electromagnetic and haemodynamic networks systematically converge in unimodal cortex and diverge in transmodal cortex.
by: Golia Shafiei, et al.
Published: (2022-08-01)

Receptor-informed network control theory links LSD and psilocybin to a flattening of the brain’s control energy landscape
by: S. Parker Singleton, et al.
Published: (2022-10-01)

Genetic and phylogenetic uncoupling of structure and function in human transmodal cortex
by: Sofie L. Valk, et al.
Published: (2022-05-01)

The effects of psilocybin and MDMA on between-network resting state functional connectivity in healthy volunteers
by: Leor eRoseman, et al.
Published: (2014-05-01)

Psychedelics, Meditation, and Self-Consciousness
by: Raphaël Millière, et al.
Published: (2018-09-01)

Psychedelics alter metaphysical beliefs
by: Christopher Timmermann, et al.
Published: (2021-11-01)

LSD and psilocybin for chronic nociplastic pain: A narrative review of the literature supporting the use of classic psychedelic agents in chronic pain
by: J Van Der Walt, et al.
Published: (2023-11-01)

Effects of psilocybin, psychedelic mushroom extract and 5-hydroxytryptophan on brain immediate early gene expression: Interaction with serotonergic receptor modulators
by: Elad Lerer, et al.
Published: (2024-04-01)

Serotonergic Psychedelics in Neural Plasticity
by: Kacper Lukasiewicz, et al.
Published: (2021-10-01)

Survey of subjective "God encounter experiences": Comparisons among naturally occurring experiences and those occasioned by the classic psychedelics psilocybin, LSD, ayahuasca, or DMT.
by: Roland R Griffiths, et al.
Published: (2019-01-01)

LSD alters dynamic integration and segregation in the human brain
by: Andrea I. Luppi, et al.
Published: (2021-02-01)

Different hierarchical reconfigurations in the brain by psilocybin and escitalopram for depression
by: Deco, G, et al.
Published: (2024)

Effects of psilocybin versus escitalopram on rumination and thought suppression in depression
by: Tommaso Barba, et al.
Published: (2022-09-01)

Self-Medication for Chronic Pain Using Classic Psychedelics: A Qualitative Investigation to Inform Future Research
by: Julia Bornemann, et al.
Published: (2021-11-01)

Co-use of MDMA with psilocybin/LSD may buffer against challenging experiences and enhance positive experiences
by: Richard J. Zeifman, et al.
Published: (2023-08-01)

Predicting Responses to Psychedelics: A Prospective Study
by: Eline C. H. M. Haijen, et al.
Published: (2018-11-01)

Psychedelics and sexual functioning: a mixed-methods study
by: Tommaso Barba, et al.
Published: (2024-02-01)

The psychedelic afterglow phenomenon: a systematic review of subacute effects of classic serotonergic psychedelics
by: Ricarda Evens, et al.
Published: (2023-05-01)

Editorial: Psychedelic sociality: Pharmacological and extrapharmacological perspectives
by: Leor Roseman, et al.
Published: (2022-07-01)

MODULATION OF SYNAPTIC FUNCTION AND NEURONAL NETWORK ACTIVITY BY SEROTONERGIC PSYCHEDELICS
by: Aneta Petrušková, et al.
Published: (2023-10-01)

Brain dynamics predictive of response to psilocybin for treatment-resistant depression
by: Vohryzek, J, et al.
Published: (2024)

Enhanced brain structure-function tethering in transmodal cortex revealed by high-frequency eigenmodes
by: Yaqian Yang, et al.
Published: (2023-10-01)

Drugs in therapy. LSD, MDMA, marijuana, psilocybin, designer drugs and its potential in modern medicine.
by: Agata Tadeja
Published: (2020-09-01)

Neuroendocrine Associations Underlying the Persistent Therapeutic Effects of Classic Serotonergic Psychedelics
by: Emmanuelle A. D. Schindler, et al.
Published: (2018-03-01)

Public Interest in Psilocybin and Psychedelic Therapy in the Context of the COVID-19 Pandemic: Google Trends Analysis
by: George Danias, et al.
Published: (2023-12-01)

An expanding manifold in transmodal regions characterizes adolescent reconfiguration of structural connectome organization
by: Bo-yong Park, et al.
Published: (2021-03-01)

Dynamical exploration of the repertoire of brain networks at rest is modulated by psilocybin
by: Lord, L-D, et al.
Published: (2019)

Effects of classic psychedelic drugs on turbulent signatures in brain dynamics
by: Josephine Cruzat, et al.
Published: (2022-01-01)

LSD-induced changes in the functional connectivity of distinct thalamic nuclei
by: Stefano Delli Pizzi, et al.
Published: (2023-12-01)

Race and ethnicity moderate the associations between lifetime psychedelic use (MDMA and psilocybin) and psychological distress and suicidality
by: Grant M. Jones, et al.
Published: (2022-10-01)

Neuropsychological Functioning in Users of Serotonergic Psychedelics – A Systematic Review and Meta-Analysis
by: Lukas A. Basedow, et al.
Published: (2021-09-01)

Connectome-harmonic decomposition of human brain activity reveals dynamical repertoire re-organization under LSD
by: Atasoy, S, et al.
Published: (2017)

Psychedelic therapy in the treatment of addiction: the past, present and future
by: Rayyan Zafar, et al.
Published: (2023-06-01)

Serotonergic psychedelics for depression: What do we know about neurobiological mechanisms of action?
by: Muhammad Ishrat Husain, et al.
Published: (2023-02-01)

Contesting Discourses and Transmodalization in J.M.Coetzee’s Fiction
by: Sadia Ghaznavi
Published: (2021-12-01)

Neural Correlates of Preference: A Transmodal Validation Study
by: Henrique T. Akiba, et al.
Published: (2019-03-01)

Psychedelic-Assisted Psychotherapy After COVID-19: The Therapeutic Uses of Psilocybin and MDMA for Pandemic-Related Mental Health Problems
by: Elena Argento, et al.
Published: (2021-09-01)