Circadian rhythms modulate the effect of eccentric exercise on rat soleus muscles.
We investigated whether time-of-day dependent changes in the rat soleus (SOL) muscle size, after eccentric exercises, operate via the mechanistic target of rapamycin (mTOR) signaling pathway. For our first experiment, we assigned 9-week-old male Wistar rats randomly into four groups: light phase (ze...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2022-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0264171 |
| _version_ | 1819018519832952832 |
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| author | Shuo-Wen Chang Toshinori Yoshihara Takamasa Tsuzuki Toshiharu Natsume Ryo Kakigi Shuichi Machida Hisashi Naito |
| author_facet | Shuo-Wen Chang Toshinori Yoshihara Takamasa Tsuzuki Toshiharu Natsume Ryo Kakigi Shuichi Machida Hisashi Naito |
| author_sort | Shuo-Wen Chang |
| collection | DOAJ |
| description | We investigated whether time-of-day dependent changes in the rat soleus (SOL) muscle size, after eccentric exercises, operate via the mechanistic target of rapamycin (mTOR) signaling pathway. For our first experiment, we assigned 9-week-old male Wistar rats randomly into four groups: light phase (zeitgeber time; ZT6) non-trained control, dark phase (ZT18) non-trained control, light phase-trained, and dark phase-trained. Trained animals performed 90 min of downhill running once every 3 d for 8 weeks. The second experiment involved dividing 9-week-old male Wistar rats to control and exercise groups. The latter were subjected to 15 min of downhill running at ZT6 and ZT18. The absolute (+12.8%) and relative (+9.4%) SOL muscle weights were higher in the light phase-trained group. p70S6K phosphorylation ratio was 42.6% higher in the SOL muscle of rats that had exercised only in light (non-trained ZT6). Collectively, the degree of muscle hypertrophy in SOL is time-of-day dependent, perhaps via the mTOR/p70S6K signaling. |
| first_indexed | 2024-12-21T03:20:43Z |
| format | Article |
| id | doaj.art-61826d89c397403ea032ee50b36e2b91 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-21T03:20:43Z |
| publishDate | 2022-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-61826d89c397403ea032ee50b36e2b912022-12-21T19:17:42ZengPublic Library of Science (PLoS)PLoS ONE1932-62032022-01-01172e026417110.1371/journal.pone.0264171Circadian rhythms modulate the effect of eccentric exercise on rat soleus muscles.Shuo-Wen ChangToshinori YoshiharaTakamasa TsuzukiToshiharu NatsumeRyo KakigiShuichi MachidaHisashi NaitoWe investigated whether time-of-day dependent changes in the rat soleus (SOL) muscle size, after eccentric exercises, operate via the mechanistic target of rapamycin (mTOR) signaling pathway. For our first experiment, we assigned 9-week-old male Wistar rats randomly into four groups: light phase (zeitgeber time; ZT6) non-trained control, dark phase (ZT18) non-trained control, light phase-trained, and dark phase-trained. Trained animals performed 90 min of downhill running once every 3 d for 8 weeks. The second experiment involved dividing 9-week-old male Wistar rats to control and exercise groups. The latter were subjected to 15 min of downhill running at ZT6 and ZT18. The absolute (+12.8%) and relative (+9.4%) SOL muscle weights were higher in the light phase-trained group. p70S6K phosphorylation ratio was 42.6% higher in the SOL muscle of rats that had exercised only in light (non-trained ZT6). Collectively, the degree of muscle hypertrophy in SOL is time-of-day dependent, perhaps via the mTOR/p70S6K signaling.https://doi.org/10.1371/journal.pone.0264171 |
| spellingShingle | Shuo-Wen Chang Toshinori Yoshihara Takamasa Tsuzuki Toshiharu Natsume Ryo Kakigi Shuichi Machida Hisashi Naito Circadian rhythms modulate the effect of eccentric exercise on rat soleus muscles. PLoS ONE |
| title | Circadian rhythms modulate the effect of eccentric exercise on rat soleus muscles. |
| title_full | Circadian rhythms modulate the effect of eccentric exercise on rat soleus muscles. |
| title_fullStr | Circadian rhythms modulate the effect of eccentric exercise on rat soleus muscles. |
| title_full_unstemmed | Circadian rhythms modulate the effect of eccentric exercise on rat soleus muscles. |
| title_short | Circadian rhythms modulate the effect of eccentric exercise on rat soleus muscles. |
| title_sort | circadian rhythms modulate the effect of eccentric exercise on rat soleus muscles |
| url | https://doi.org/10.1371/journal.pone.0264171 |
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