A comprehensive pan-cancer analysis of the expression characteristics, prognostic value, and immune characteristics of TOP1MT
Background: Mitochondria are at the heart of a number of metabolic pathways providing enormous energy for normal cell growth and regulating tumor cell growth as well as survival. Mitochondrial topoisomerase I (TOP1MT) is a type IB topoisomerase found in the mitochondria of vertebrates. However, no p...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Genetics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fgene.2022.920897/full |
| _version_ | 1811309249815379968 |
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| author | Lihong Fei Zhimin Lu Yufen Xu Guoxin Hou |
| author_facet | Lihong Fei Zhimin Lu Yufen Xu Guoxin Hou |
| author_sort | Lihong Fei |
| collection | DOAJ |
| description | Background: Mitochondria are at the heart of a number of metabolic pathways providing enormous energy for normal cell growth and regulating tumor cell growth as well as survival. Mitochondrial topoisomerase I (TOP1MT) is a type IB topoisomerase found in the mitochondria of vertebrates. However, no pan-cancer analysis of TOP1MT has been reported. This study aims to explore TOP1MT expression in pan-cancer tissues and identify whether it can be a target for mitochondrial anticancer therapy.Methods and results: The original TOP1MT expression data in 33 different types of cancer patients were downloaded from the TCGA and GTEx databases. TOP1MT was highly expressed in cancer tissues, including BLCA, BRCA, CHOL, COAD, DLBC, ESCA, GBM, HNSC, KIRC, KIRP, LGG, LIHC, LUAD, LUSC, PAAD, PCPG, PRAD, READ, SKCM, STAD, THYM, UCEC, and UCS. According to Kaplan-Meier survival curve analysis, high TOP1MT expression in BLCA, HNSC, KIRP, PAAD, UCEC, and LIHC cancer tissues was linked to poor prognosis of cancer patients, i.e., poor OS, disease-specific survival, and PFI. Linkedomics analysis identified a positive correlation of TOP1MT expression with CNA, but a negative correlation with methylation. TOP1MT expression significantly correlated with immune cells and immune checkpoints in the TIMER database. Functional analysis showed a close relationship between TOP1MT expression and ribosomes.Conclusion: In summary, TOP1MT is a potential biomarker for mitochondrial anticancer therapy and cancer immunotherapy. |
| first_indexed | 2024-04-13T09:38:55Z |
| format | Article |
| id | doaj.art-6182713cbb3e4ee69f20d57397078791 |
| institution | Directory Open Access Journal |
| issn | 1664-8021 |
| language | English |
| last_indexed | 2024-04-13T09:38:55Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Genetics |
| spelling | doaj.art-6182713cbb3e4ee69f20d573970787912022-12-22T02:52:01ZengFrontiers Media S.A.Frontiers in Genetics1664-80212022-08-011310.3389/fgene.2022.920897920897A comprehensive pan-cancer analysis of the expression characteristics, prognostic value, and immune characteristics of TOP1MTLihong Fei0Zhimin Lu1Yufen Xu2Guoxin Hou3Department of Gastroenterology, The First Hospital of Jiaxing, Affiliated Hospital of Jiaxing University, Jiaxing, Zhejiang, ChinaDepartment of Outpatient, The First Hospital of Jiaxing, Affiliated Hospital of Jiaxing University, Jiaxing, Zhejiang, ChinaDepartment of Oncology, The First Hospital of Jiaxing, Affiliated Hospital of Jiaxing University, Jiaxing, Zhejiang, ChinaDepartment of Oncology, The First Hospital of Jiaxing, Affiliated Hospital of Jiaxing University, Jiaxing, Zhejiang, ChinaBackground: Mitochondria are at the heart of a number of metabolic pathways providing enormous energy for normal cell growth and regulating tumor cell growth as well as survival. Mitochondrial topoisomerase I (TOP1MT) is a type IB topoisomerase found in the mitochondria of vertebrates. However, no pan-cancer analysis of TOP1MT has been reported. This study aims to explore TOP1MT expression in pan-cancer tissues and identify whether it can be a target for mitochondrial anticancer therapy.Methods and results: The original TOP1MT expression data in 33 different types of cancer patients were downloaded from the TCGA and GTEx databases. TOP1MT was highly expressed in cancer tissues, including BLCA, BRCA, CHOL, COAD, DLBC, ESCA, GBM, HNSC, KIRC, KIRP, LGG, LIHC, LUAD, LUSC, PAAD, PCPG, PRAD, READ, SKCM, STAD, THYM, UCEC, and UCS. According to Kaplan-Meier survival curve analysis, high TOP1MT expression in BLCA, HNSC, KIRP, PAAD, UCEC, and LIHC cancer tissues was linked to poor prognosis of cancer patients, i.e., poor OS, disease-specific survival, and PFI. Linkedomics analysis identified a positive correlation of TOP1MT expression with CNA, but a negative correlation with methylation. TOP1MT expression significantly correlated with immune cells and immune checkpoints in the TIMER database. Functional analysis showed a close relationship between TOP1MT expression and ribosomes.Conclusion: In summary, TOP1MT is a potential biomarker for mitochondrial anticancer therapy and cancer immunotherapy.https://www.frontiersin.org/articles/10.3389/fgene.2022.920897/fullTOP1MTpan-cancerprognosisbiomarkerimmunity |
| spellingShingle | Lihong Fei Zhimin Lu Yufen Xu Guoxin Hou A comprehensive pan-cancer analysis of the expression characteristics, prognostic value, and immune characteristics of TOP1MT Frontiers in Genetics TOP1MT pan-cancer prognosis biomarker immunity |
| title | A comprehensive pan-cancer analysis of the expression characteristics, prognostic value, and immune characteristics of TOP1MT |
| title_full | A comprehensive pan-cancer analysis of the expression characteristics, prognostic value, and immune characteristics of TOP1MT |
| title_fullStr | A comprehensive pan-cancer analysis of the expression characteristics, prognostic value, and immune characteristics of TOP1MT |
| title_full_unstemmed | A comprehensive pan-cancer analysis of the expression characteristics, prognostic value, and immune characteristics of TOP1MT |
| title_short | A comprehensive pan-cancer analysis of the expression characteristics, prognostic value, and immune characteristics of TOP1MT |
| title_sort | comprehensive pan cancer analysis of the expression characteristics prognostic value and immune characteristics of top1mt |
| topic | TOP1MT pan-cancer prognosis biomarker immunity |
| url | https://www.frontiersin.org/articles/10.3389/fgene.2022.920897/full |
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