Adenosine reduces sinoatrial node cell action potential firing rate by uncoupling its membrane and calcium clocks

Adenosine reduces sinoatrial node cell action potential firing rate by uncoupling its membrane and calcium clocks

The spontaneous action potential (AP) firing rate of sinoatrial nodal cells (SANC) is regulated by a system of intracellular Ca2+ and membrane ion current clocks driven by Ca2+-calmodulin-activated adenylyl cyclase-protein kinase-A signaling. The mean AP-cycle length (APCL) and APCL variability info...

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Bibliographic Details
Main Authors: Ashley N. Wirth, Kenta Tsutsui, Victor A. Maltsev, Edward G. Lakatta
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Physiology
Subjects:
sinoatrial node (SAN)
adenosine
coupled-clock pacemaker system
calcium release
sarcoplasmic reticulum (SR)
cardiac arrhythmia
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2022.977807/full

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