Comparison of Two Different Dosing Regimens with Lymecycline, in Association with Adapalene, in Inflammatory Acne
Combined treatment with oral lymecycline and topical adapalene has been shown to induce greater and faster improvement of acne than monotherapy with lymecycline. We wanted to evaluate the effects of combined therapy with topical adapalene (cream or gel) plus oral lymecycline used at different dosage...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2005-05-01
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| Series: | European Journal of Inflammation |
| Online Access: | https://doi.org/10.1177/1721727X0500300206 |
| _version_ | 1819106557456023552 |
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| author | G.A. Vena N. Cassano G. Alessandrini G. Carrieri D. Fai M. Gabellone P. Ligori G. Maietta C. Malvindi A. Mancino G. Martina S. Pellè F. Ricciuti A. Ruggiero E. Serratì M.R. Sodo R. Stasi |
| author_facet | G.A. Vena N. Cassano G. Alessandrini G. Carrieri D. Fai M. Gabellone P. Ligori G. Maietta C. Malvindi A. Mancino G. Martina S. Pellè F. Ricciuti A. Ruggiero E. Serratì M.R. Sodo R. Stasi |
| author_sort | G.A. Vena |
| collection | DOAJ |
| description | Combined treatment with oral lymecycline and topical adapalene has been shown to induce greater and faster improvement of acne than monotherapy with lymecycline. We wanted to evaluate the effects of combined therapy with topical adapalene (cream or gel) plus oral lymecycline used at different dosages (group A: 300mg/day for 2 weeks and then 150mg/day for 14 weeks; group B: 300mg/day for 16 weeks) in 242 patients with inflammatory acne. Both dosage regimens were well tolerated in the majority of patients and significantly improved both the acne lesion count and seborrhoea. There was a trend towards a greater reduction of seborrhoea and nodules in patients of group B. After the initial 16-week phase, patients entered an 8-week follow-up phase, consisting of the use of adapalene monotherapy. The results obtained after this phase confirm the therapeutic value and the favourable tolerability of adapalene as maintenance treatment after successful treatment of inflammatory acne. At the same time, a significantly reduced count of comedones was observed in patients of group B as compared with group A, suggesting that prolonged use of high-dose lymecycline may have a more pronounced influence on comedogenesis. |
| first_indexed | 2024-12-22T02:40:02Z |
| format | Article |
| id | doaj.art-6185a03308084dbfa561b22f648983fc |
| institution | Directory Open Access Journal |
| issn | 1721-727X |
| language | English |
| last_indexed | 2024-12-22T02:40:02Z |
| publishDate | 2005-05-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | European Journal of Inflammation |
| spelling | doaj.art-6185a03308084dbfa561b22f648983fc2022-12-21T18:41:40ZengSAGE PublishingEuropean Journal of Inflammation1721-727X2005-05-01310.1177/1721727X0500300206Comparison of Two Different Dosing Regimens with Lymecycline, in Association with Adapalene, in Inflammatory AcneG.A. VenaN. CassanoG. Alessandrini0G. Carrieri1D. Fai2M. Gabellone3P. Ligori4G. Maietta5C. Malvindi6A. Mancino7G. Martina8S. Pellè9F. Ricciuti10A. Ruggiero11E. Serratì12M.R. Sodo13R. Stasi14 Collegio Salentino di Dermatologia, Italy Collegio Salentino di Dermatologia, Italy Collegio Salentino di Dermatologia, Italy Collegio Salentino di Dermatologia, Italy Collegio Salentino di Dermatologia, Italy Collegio Salentino di Dermatologia, Italy Collegio Salentino di Dermatologia, Italy Collegio Salentino di Dermatologia, Italy Collegio Salentino di Dermatologia, Italy Collegio Salentino di Dermatologia, Italy Unit of Dermatology, Ospedale “San Carlo”, Potenza, Italy Collegio Salentino di Dermatologia, Italy Collegio Salentino di Dermatologia, Italy Collegio Salentino di Dermatologia, Italy Collegio Salentino di Dermatologia, ItalyCombined treatment with oral lymecycline and topical adapalene has been shown to induce greater and faster improvement of acne than monotherapy with lymecycline. We wanted to evaluate the effects of combined therapy with topical adapalene (cream or gel) plus oral lymecycline used at different dosages (group A: 300mg/day for 2 weeks and then 150mg/day for 14 weeks; group B: 300mg/day for 16 weeks) in 242 patients with inflammatory acne. Both dosage regimens were well tolerated in the majority of patients and significantly improved both the acne lesion count and seborrhoea. There was a trend towards a greater reduction of seborrhoea and nodules in patients of group B. After the initial 16-week phase, patients entered an 8-week follow-up phase, consisting of the use of adapalene monotherapy. The results obtained after this phase confirm the therapeutic value and the favourable tolerability of adapalene as maintenance treatment after successful treatment of inflammatory acne. At the same time, a significantly reduced count of comedones was observed in patients of group B as compared with group A, suggesting that prolonged use of high-dose lymecycline may have a more pronounced influence on comedogenesis.https://doi.org/10.1177/1721727X0500300206 |
| spellingShingle | G.A. Vena N. Cassano G. Alessandrini G. Carrieri D. Fai M. Gabellone P. Ligori G. Maietta C. Malvindi A. Mancino G. Martina S. Pellè F. Ricciuti A. Ruggiero E. Serratì M.R. Sodo R. Stasi Comparison of Two Different Dosing Regimens with Lymecycline, in Association with Adapalene, in Inflammatory Acne European Journal of Inflammation |
| title | Comparison of Two Different Dosing Regimens with Lymecycline, in Association with Adapalene, in Inflammatory Acne |
| title_full | Comparison of Two Different Dosing Regimens with Lymecycline, in Association with Adapalene, in Inflammatory Acne |
| title_fullStr | Comparison of Two Different Dosing Regimens with Lymecycline, in Association with Adapalene, in Inflammatory Acne |
| title_full_unstemmed | Comparison of Two Different Dosing Regimens with Lymecycline, in Association with Adapalene, in Inflammatory Acne |
| title_short | Comparison of Two Different Dosing Regimens with Lymecycline, in Association with Adapalene, in Inflammatory Acne |
| title_sort | comparison of two different dosing regimens with lymecycline in association with adapalene in inflammatory acne |
| url | https://doi.org/10.1177/1721727X0500300206 |
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