Unlocking the Potential of Acetazolamide: A Literature Review of an Adjunctive Approach in Heart Failure Management
<b>Background:</b> Heart failure (HF) patients often experience persistent fluid overload despite standard diuretic therapy. The adjunctive use of acetazolamide, a carbonic anhydrase inhibitor, in combination with loop diuretics has shown promise in improving decongestion and diuretic ef...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-01-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/13/1/288 |
| _version_ | 1797358530294972416 |
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| author | Michael Sabina Zein Barakat Adrian Feliciano Andrew Lamb M Mrhaf Alsamman |
| author_facet | Michael Sabina Zein Barakat Adrian Feliciano Andrew Lamb M Mrhaf Alsamman |
| author_sort | Michael Sabina |
| collection | DOAJ |
| description | <b>Background:</b> Heart failure (HF) patients often experience persistent fluid overload despite standard diuretic therapy. The adjunctive use of acetazolamide, a carbonic anhydrase inhibitor, in combination with loop diuretics has shown promise in improving decongestion and diuretic efficacy. This literature review aims to analyze six studies evaluating the effectiveness of acetazolamide as an additive treatment for acute decompensated heart failure (ADHF) and its impact on various outcomes. <b>Methods:</b> We searched the PubMed database using the terms “acetazolamide heart failure”. We refined our search with specific filters (as shown our PRISMA flow diagram) and exclusion criteria, narrowing down our results to five studies. We included an extra study via expert recommendation, ultimately including six studies for comprehensive analysis. <b>Results:</b> The review highlights the positive effects of acetazolamide on decongestion, natriuresis, and diuresis in HF patients. However, it also showcases the limitations of these trials. <b>Discussion:</b> While the reviewed studies demonstrate the potential benefits of acetazolamide in enhancing decongestion and diuretic efficiency, there are limitations to consider, including small sample sizes, lack of blinding, and limited external validity. Further research is needed to confirm these findings, compare acetazolamide with other diuretic combinations, and explore its effects in a broader population of heart failure patients, including those in the United States. The use of acetazolamide in HF management warrants continued investigation to optimize its role in improving decongestion and patient outcomes. |
| first_indexed | 2024-03-08T15:03:20Z |
| format | Article |
| id | doaj.art-6187490a6adf4c60977be746eab9e7de |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-08T15:03:20Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-6187490a6adf4c60977be746eab9e7de2024-01-10T15:01:58ZengMDPI AGJournal of Clinical Medicine2077-03832024-01-0113128810.3390/jcm13010288Unlocking the Potential of Acetazolamide: A Literature Review of an Adjunctive Approach in Heart Failure ManagementMichael Sabina0Zein Barakat1Adrian Feliciano2Andrew Lamb3M Mrhaf Alsamman4Lakeland Regional Health Medical Center, Lakeland 33805-4500, FL, USALakeland Regional Health Medical Center, Lakeland 33805-4500, FL, USALakeland Regional Health Medical Center, Lakeland 33805-4500, FL, USALakeland Regional Health Medical Center, Lakeland 33805-4500, FL, USALakeland Regional Health Medical Center, Lakeland 33805-4500, FL, USA<b>Background:</b> Heart failure (HF) patients often experience persistent fluid overload despite standard diuretic therapy. The adjunctive use of acetazolamide, a carbonic anhydrase inhibitor, in combination with loop diuretics has shown promise in improving decongestion and diuretic efficacy. This literature review aims to analyze six studies evaluating the effectiveness of acetazolamide as an additive treatment for acute decompensated heart failure (ADHF) and its impact on various outcomes. <b>Methods:</b> We searched the PubMed database using the terms “acetazolamide heart failure”. We refined our search with specific filters (as shown our PRISMA flow diagram) and exclusion criteria, narrowing down our results to five studies. We included an extra study via expert recommendation, ultimately including six studies for comprehensive analysis. <b>Results:</b> The review highlights the positive effects of acetazolamide on decongestion, natriuresis, and diuresis in HF patients. However, it also showcases the limitations of these trials. <b>Discussion:</b> While the reviewed studies demonstrate the potential benefits of acetazolamide in enhancing decongestion and diuretic efficiency, there are limitations to consider, including small sample sizes, lack of blinding, and limited external validity. Further research is needed to confirm these findings, compare acetazolamide with other diuretic combinations, and explore its effects in a broader population of heart failure patients, including those in the United States. The use of acetazolamide in HF management warrants continued investigation to optimize its role in improving decongestion and patient outcomes.https://www.mdpi.com/2077-0383/13/1/288acetazolamideheart failurediuresisliterature reviewtrialsnatriuresis |
| spellingShingle | Michael Sabina Zein Barakat Adrian Feliciano Andrew Lamb M Mrhaf Alsamman Unlocking the Potential of Acetazolamide: A Literature Review of an Adjunctive Approach in Heart Failure Management Journal of Clinical Medicine acetazolamide heart failure diuresis literature review trials natriuresis |
| title | Unlocking the Potential of Acetazolamide: A Literature Review of an Adjunctive Approach in Heart Failure Management |
| title_full | Unlocking the Potential of Acetazolamide: A Literature Review of an Adjunctive Approach in Heart Failure Management |
| title_fullStr | Unlocking the Potential of Acetazolamide: A Literature Review of an Adjunctive Approach in Heart Failure Management |
| title_full_unstemmed | Unlocking the Potential of Acetazolamide: A Literature Review of an Adjunctive Approach in Heart Failure Management |
| title_short | Unlocking the Potential of Acetazolamide: A Literature Review of an Adjunctive Approach in Heart Failure Management |
| title_sort | unlocking the potential of acetazolamide a literature review of an adjunctive approach in heart failure management |
| topic | acetazolamide heart failure diuresis literature review trials natriuresis |
| url | https://www.mdpi.com/2077-0383/13/1/288 |
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