Pd(OAc)2-catalyzed asymmetric hydrogenation of sterically hindered N-tosylimines
Sterically hindered unsaturated compounds are challenging substrates for asymmetric hydrogenation. Here, the authors report a palladium/chiral (bis)phosphine catalytic system that hydrogenates a number of hindered N-tosylimines with excellent enantioselectivitites.
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2018-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-07462-w |
| _version_ | 1818952174316552192 |
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| author | Jianzhong Chen Zhenfeng Zhang Bowen Li Feilong Li Yulin Wang Min Zhao Ilya D. Gridnev Tsuneo Imamoto Wanbin Zhang |
| author_facet | Jianzhong Chen Zhenfeng Zhang Bowen Li Feilong Li Yulin Wang Min Zhao Ilya D. Gridnev Tsuneo Imamoto Wanbin Zhang |
| author_sort | Jianzhong Chen |
| collection | DOAJ |
| description | Sterically hindered unsaturated compounds are challenging substrates for asymmetric hydrogenation. Here, the authors report a palladium/chiral (bis)phosphine catalytic system that hydrogenates a number of hindered N-tosylimines with excellent enantioselectivitites. |
| first_indexed | 2024-12-20T09:46:11Z |
| format | Article |
| id | doaj.art-61887082b7564dc1b11a43ae2c800e82 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-20T09:46:11Z |
| publishDate | 2018-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-61887082b7564dc1b11a43ae2c800e822022-12-21T19:44:44ZengNature PortfolioNature Communications2041-17232018-11-019111010.1038/s41467-018-07462-wPd(OAc)2-catalyzed asymmetric hydrogenation of sterically hindered N-tosyliminesJianzhong Chen0Zhenfeng Zhang1Bowen Li2Feilong Li3Yulin Wang4Min Zhao5Ilya D. Gridnev6Tsuneo Imamoto7Wanbin Zhang8Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong UniversityShanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong UniversityShanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong UniversitySchool of Chemistry and Molecular Engineering, East China University of Science and TechnologySchool of Chemistry and Molecular Engineering, East China University of Science and TechnologySchool of Chemistry and Molecular Engineering, East China University of Science and TechnologyDepartment of Chemistry, Graduate School of Science, Tohoku University, Aramaki 3-6, Aoba-kuDepartment of Chemistry, Graduate School of Science, Chiba UniversityShanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong UniversitySterically hindered unsaturated compounds are challenging substrates for asymmetric hydrogenation. Here, the authors report a palladium/chiral (bis)phosphine catalytic system that hydrogenates a number of hindered N-tosylimines with excellent enantioselectivitites.https://doi.org/10.1038/s41467-018-07462-w |
| spellingShingle | Jianzhong Chen Zhenfeng Zhang Bowen Li Feilong Li Yulin Wang Min Zhao Ilya D. Gridnev Tsuneo Imamoto Wanbin Zhang Pd(OAc)2-catalyzed asymmetric hydrogenation of sterically hindered N-tosylimines Nature Communications |
| title | Pd(OAc)2-catalyzed asymmetric hydrogenation of sterically hindered N-tosylimines |
| title_full | Pd(OAc)2-catalyzed asymmetric hydrogenation of sterically hindered N-tosylimines |
| title_fullStr | Pd(OAc)2-catalyzed asymmetric hydrogenation of sterically hindered N-tosylimines |
| title_full_unstemmed | Pd(OAc)2-catalyzed asymmetric hydrogenation of sterically hindered N-tosylimines |
| title_short | Pd(OAc)2-catalyzed asymmetric hydrogenation of sterically hindered N-tosylimines |
| title_sort | pd oac 2 catalyzed asymmetric hydrogenation of sterically hindered n tosylimines |
| url | https://doi.org/10.1038/s41467-018-07462-w |
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