Albumin-globulin ratio and mortality in patients on peritoneal dialysis: a retrospective study
Abstract Background Albumin-globulin ratio (AGR), a variable based on serum albumin and non-albumin proteins, has been demonstrated as a predictor of mortality in patients with malignant neoplasm. The aim of this study was to evaluate the prognostic value of AGR on peritoneal dialysis (PD) patients....
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| Language: | English |
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BMC
2020-02-01
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| Series: | BMC Nephrology |
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| Online Access: | https://doi.org/10.1186/s12882-020-1707-1 |
| _version_ | 1819179666046451712 |
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| author | Fenfen Peng Lingzhi Sun Ting Chen Yan Zhu Weidong Zhou Peilin Li Yihua Chen Yiyi Zhuang Qianyin Huang Haibo Long |
| author_facet | Fenfen Peng Lingzhi Sun Ting Chen Yan Zhu Weidong Zhou Peilin Li Yihua Chen Yiyi Zhuang Qianyin Huang Haibo Long |
| author_sort | Fenfen Peng |
| collection | DOAJ |
| description | Abstract Background Albumin-globulin ratio (AGR), a variable based on serum albumin and non-albumin proteins, has been demonstrated as a predictor of mortality in patients with malignant neoplasm. The aim of this study was to evaluate the prognostic value of AGR on peritoneal dialysis (PD) patients. Methods We retrospectively analyzed 602 incident PD patients from January 1st, 2008, to December 31st, 2017, at our center and followed them until December 31st, 2018. Kaplan-Meier curves and multivariate Cox regression models were applied to analyze the association between AGR and all-cause of mortality and cardiovascular mortality. Results The median follow-up time was 32.17 (interquartile range = 32.80) months. During follow-up, 131 (21.8%) patients died, including 57 patients (43.5%) who died due to cardiovascular diseases. Kaplan-Meier curves showed that patients with AGR > 1.26 had better rates of survival than those with AGR ≤ 1.25 (p < 0.001). After adjusting for potential confounders, the lower AGR level was significantly associated with an increased all-cause and cardiovascular mortality [hazard ratio (HR): 1.57, 95% confidence interval (CI): 1.07–2.32, p = 0.022 and HR: 2.01, 95% CI: 1.10–3.69, p = 0.023 respectively]. Conclusions Patients with a low AGR level had an increased all-cause and cardiovascular mortality. AGR may be a useful index in identifying patients on PD at risk for CVD and all-cause of mortality. |
| first_indexed | 2024-12-22T22:02:04Z |
| format | Article |
| id | doaj.art-618a03f3137846ffa953c586e7302c39 |
| institution | Directory Open Access Journal |
| issn | 1471-2369 |
| language | English |
| last_indexed | 2024-12-22T22:02:04Z |
| publishDate | 2020-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Nephrology |
| spelling | doaj.art-618a03f3137846ffa953c586e7302c392022-12-21T18:11:05ZengBMCBMC Nephrology1471-23692020-02-012111910.1186/s12882-020-1707-1Albumin-globulin ratio and mortality in patients on peritoneal dialysis: a retrospective studyFenfen Peng0Lingzhi Sun1Ting Chen2Yan Zhu3Weidong Zhou4Peilin Li5Yihua Chen6Yiyi Zhuang7Qianyin Huang8Haibo Long9Department of Nephrology, Zhujiang Hospital of Southern Medical UniversityDepartment of Nephrology, Zhujiang Hospital of Southern Medical UniversityDepartment of Nephrology, Zhujiang Hospital of Southern Medical UniversityDepartment of Nephrology, Zhujiang Hospital of Southern Medical UniversityDepartment of Nephrology, Zhujiang Hospital of Southern Medical UniversityDepartment of Nephrology, Zhujiang Hospital of Southern Medical UniversityDepartment of Nephrology, Zhujiang Hospital of Southern Medical UniversityDepartment of Nephrology, Zhujiang Hospital of Southern Medical UniversityDepartment of Nephrology, Zhujiang Hospital of Southern Medical UniversityDepartment of Nephrology, Zhujiang Hospital of Southern Medical UniversityAbstract Background Albumin-globulin ratio (AGR), a variable based on serum albumin and non-albumin proteins, has been demonstrated as a predictor of mortality in patients with malignant neoplasm. The aim of this study was to evaluate the prognostic value of AGR on peritoneal dialysis (PD) patients. Methods We retrospectively analyzed 602 incident PD patients from January 1st, 2008, to December 31st, 2017, at our center and followed them until December 31st, 2018. Kaplan-Meier curves and multivariate Cox regression models were applied to analyze the association between AGR and all-cause of mortality and cardiovascular mortality. Results The median follow-up time was 32.17 (interquartile range = 32.80) months. During follow-up, 131 (21.8%) patients died, including 57 patients (43.5%) who died due to cardiovascular diseases. Kaplan-Meier curves showed that patients with AGR > 1.26 had better rates of survival than those with AGR ≤ 1.25 (p < 0.001). After adjusting for potential confounders, the lower AGR level was significantly associated with an increased all-cause and cardiovascular mortality [hazard ratio (HR): 1.57, 95% confidence interval (CI): 1.07–2.32, p = 0.022 and HR: 2.01, 95% CI: 1.10–3.69, p = 0.023 respectively]. Conclusions Patients with a low AGR level had an increased all-cause and cardiovascular mortality. AGR may be a useful index in identifying patients on PD at risk for CVD and all-cause of mortality.https://doi.org/10.1186/s12882-020-1707-1Albumin-globulin ratioPeritoneal dialysisMortality |
| spellingShingle | Fenfen Peng Lingzhi Sun Ting Chen Yan Zhu Weidong Zhou Peilin Li Yihua Chen Yiyi Zhuang Qianyin Huang Haibo Long Albumin-globulin ratio and mortality in patients on peritoneal dialysis: a retrospective study BMC Nephrology Albumin-globulin ratio Peritoneal dialysis Mortality |
| title | Albumin-globulin ratio and mortality in patients on peritoneal dialysis: a retrospective study |
| title_full | Albumin-globulin ratio and mortality in patients on peritoneal dialysis: a retrospective study |
| title_fullStr | Albumin-globulin ratio and mortality in patients on peritoneal dialysis: a retrospective study |
| title_full_unstemmed | Albumin-globulin ratio and mortality in patients on peritoneal dialysis: a retrospective study |
| title_short | Albumin-globulin ratio and mortality in patients on peritoneal dialysis: a retrospective study |
| title_sort | albumin globulin ratio and mortality in patients on peritoneal dialysis a retrospective study |
| topic | Albumin-globulin ratio Peritoneal dialysis Mortality |
| url | https://doi.org/10.1186/s12882-020-1707-1 |
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