Different Associations between Tonsil Microbiome, Chronic Tonsillitis, and Intermittent Hypoxemia among Obstructive Sleep Apnea Children of Different Weight Status: A Pilot Case-Control Study
The tonsil microbiome is associated with chronic tonsillitis and obstructive sleep apnea (OSA) in children, and the gut microbiome is associated with host weight status. In this study, we hypothesized that weight status may be associated with clinical profiles and the tonsil microbiome in children w...
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MDPI AG
2021-05-01
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| Series: | Journal of Personalized Medicine |
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| Online Access: | https://www.mdpi.com/2075-4426/11/6/486 |
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| author | Hai-Hua Chuang Jen-Fu Hsu Li-Pang Chuang Cheng-Hsun Chiu Yen-Lin Huang Hsueh-Yu Li Ning-Hung Chen Yu-Shu Huang Chun-Wei Chuang Chung-Guei Huang Hsin-Chih Lai Li-Ang Lee |
| author_facet | Hai-Hua Chuang Jen-Fu Hsu Li-Pang Chuang Cheng-Hsun Chiu Yen-Lin Huang Hsueh-Yu Li Ning-Hung Chen Yu-Shu Huang Chun-Wei Chuang Chung-Guei Huang Hsin-Chih Lai Li-Ang Lee |
| author_sort | Hai-Hua Chuang |
| collection | DOAJ |
| description | The tonsil microbiome is associated with chronic tonsillitis and obstructive sleep apnea (OSA) in children, and the gut microbiome is associated with host weight status. In this study, we hypothesized that weight status may be associated with clinical profiles and the tonsil microbiome in children with OSA. We prospectively enrolled 33 non-healthy-weight (cases) and 33 healthy-weight (controls) pediatric OSA patients matched by the proportion of chronic tonsillitis. Differences in the tonsil microbiome between the non-healthy-weight and healthy-weight subgroups and relationships between the tonsil microbiome and clinical variables were investigated. Non-healthy weight was associated with significant intermittent hypoxemia (oxygen desaturation index, mean blood saturation (SpO<sub>2</sub>), and minimal SpO<sub>2</sub>) and higher systolic blood pressure percentile, but was not related to the tonsil microbiome. However, chronic tonsillitis was related to Acidobacteria in the non-healthy-weight subgroup, and oxygen desaturation index was associated with Bacteroidetes in the healthy-weight subgroup. In post hoc analysis, the children with mean SpO<sub>2</sub> ≤ 97% had reduced <i>α</i> and <i>β</i> diversities and a higher abundance of Bacteroidetes than those with mean SpO<sub>2</sub> > 97%. These preliminary findings are novel and provide insights into future research to understand the pathogenesis of the disease and develop personalized treatments for pediatric OSA. |
| first_indexed | 2024-03-10T10:55:33Z |
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| id | doaj.art-618b27a2476a4cd5bbdd0b91d3e6fc5b |
| institution | Directory Open Access Journal |
| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-03-10T10:55:33Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Personalized Medicine |
| spelling | doaj.art-618b27a2476a4cd5bbdd0b91d3e6fc5b2023-11-21T21:52:44ZengMDPI AGJournal of Personalized Medicine2075-44262021-05-0111648610.3390/jpm11060486Different Associations between Tonsil Microbiome, Chronic Tonsillitis, and Intermittent Hypoxemia among Obstructive Sleep Apnea Children of Different Weight Status: A Pilot Case-Control StudyHai-Hua Chuang0Jen-Fu Hsu1Li-Pang Chuang2Cheng-Hsun Chiu3Yen-Lin Huang4Hsueh-Yu Li5Ning-Hung Chen6Yu-Shu Huang7Chun-Wei Chuang8Chung-Guei Huang9Hsin-Chih Lai10Li-Ang Lee11Department of Family Medicine, Chang Gung Memorial Hospital, Taipei Branch and Linkou Main Branch, Taoyuan 33305, TaiwanCollege of Medicine, Chang Gung University, Taoyuan 33302, TaiwanCollege of Medicine, Chang Gung University, Taoyuan 33302, TaiwanCollege of Medicine, Chang Gung University, Taoyuan 33302, TaiwanCollege of Medicine, Chang Gung University, Taoyuan 33302, TaiwanCollege of Medicine, Chang Gung University, Taoyuan 33302, TaiwanCollege of Medicine, Chang Gung University, Taoyuan 33302, TaiwanCollege of Medicine, Chang Gung University, Taoyuan 33302, TaiwanDepartment of Laboratory Medicine, Chang Gung Memorial Hospital, Linkou Main Branch, Taoyuan 33305, TaiwanDepartment of Laboratory Medicine, Chang Gung Memorial Hospital, Linkou Main Branch, Taoyuan 33305, TaiwanDepartment of Laboratory Medicine, Chang Gung Memorial Hospital, Linkou Main Branch, Taoyuan 33305, TaiwanCollege of Medicine, Chang Gung University, Taoyuan 33302, TaiwanThe tonsil microbiome is associated with chronic tonsillitis and obstructive sleep apnea (OSA) in children, and the gut microbiome is associated with host weight status. In this study, we hypothesized that weight status may be associated with clinical profiles and the tonsil microbiome in children with OSA. We prospectively enrolled 33 non-healthy-weight (cases) and 33 healthy-weight (controls) pediatric OSA patients matched by the proportion of chronic tonsillitis. Differences in the tonsil microbiome between the non-healthy-weight and healthy-weight subgroups and relationships between the tonsil microbiome and clinical variables were investigated. Non-healthy weight was associated with significant intermittent hypoxemia (oxygen desaturation index, mean blood saturation (SpO<sub>2</sub>), and minimal SpO<sub>2</sub>) and higher systolic blood pressure percentile, but was not related to the tonsil microbiome. However, chronic tonsillitis was related to Acidobacteria in the non-healthy-weight subgroup, and oxygen desaturation index was associated with Bacteroidetes in the healthy-weight subgroup. In post hoc analysis, the children with mean SpO<sub>2</sub> ≤ 97% had reduced <i>α</i> and <i>β</i> diversities and a higher abundance of Bacteroidetes than those with mean SpO<sub>2</sub> > 97%. These preliminary findings are novel and provide insights into future research to understand the pathogenesis of the disease and develop personalized treatments for pediatric OSA.https://www.mdpi.com/2075-4426/11/6/486childrenintermittent hypoxemiamicrobiomeobstructive sleep apneatonsilweight status |
| spellingShingle | Hai-Hua Chuang Jen-Fu Hsu Li-Pang Chuang Cheng-Hsun Chiu Yen-Lin Huang Hsueh-Yu Li Ning-Hung Chen Yu-Shu Huang Chun-Wei Chuang Chung-Guei Huang Hsin-Chih Lai Li-Ang Lee Different Associations between Tonsil Microbiome, Chronic Tonsillitis, and Intermittent Hypoxemia among Obstructive Sleep Apnea Children of Different Weight Status: A Pilot Case-Control Study Journal of Personalized Medicine children intermittent hypoxemia microbiome obstructive sleep apnea tonsil weight status |
| title | Different Associations between Tonsil Microbiome, Chronic Tonsillitis, and Intermittent Hypoxemia among Obstructive Sleep Apnea Children of Different Weight Status: A Pilot Case-Control Study |
| title_full | Different Associations between Tonsil Microbiome, Chronic Tonsillitis, and Intermittent Hypoxemia among Obstructive Sleep Apnea Children of Different Weight Status: A Pilot Case-Control Study |
| title_fullStr | Different Associations between Tonsil Microbiome, Chronic Tonsillitis, and Intermittent Hypoxemia among Obstructive Sleep Apnea Children of Different Weight Status: A Pilot Case-Control Study |
| title_full_unstemmed | Different Associations between Tonsil Microbiome, Chronic Tonsillitis, and Intermittent Hypoxemia among Obstructive Sleep Apnea Children of Different Weight Status: A Pilot Case-Control Study |
| title_short | Different Associations between Tonsil Microbiome, Chronic Tonsillitis, and Intermittent Hypoxemia among Obstructive Sleep Apnea Children of Different Weight Status: A Pilot Case-Control Study |
| title_sort | different associations between tonsil microbiome chronic tonsillitis and intermittent hypoxemia among obstructive sleep apnea children of different weight status a pilot case control study |
| topic | children intermittent hypoxemia microbiome obstructive sleep apnea tonsil weight status |
| url | https://www.mdpi.com/2075-4426/11/6/486 |
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