Colibactin: More Than a New Bacterial Toxin
Cyclomodulins are bacterial toxins that interfere with the eukaryotic cell cycle. A new cyclomodulin called colibactin, which is synthetized by the pks genomic island, was discovered in 2006. Despite many efforts, colibactin has not yet been purified, and its structure remains elusive. Interestingly...
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MDPI AG
2018-04-01
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| Series: | Toxins |
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| Online Access: | http://www.mdpi.com/2072-6651/10/4/151 |
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| author | Tiphanie Faïs Julien Delmas Nicolas Barnich Richard Bonnet Guillaume Dalmasso |
| author_facet | Tiphanie Faïs Julien Delmas Nicolas Barnich Richard Bonnet Guillaume Dalmasso |
| author_sort | Tiphanie Faïs |
| collection | DOAJ |
| description | Cyclomodulins are bacterial toxins that interfere with the eukaryotic cell cycle. A new cyclomodulin called colibactin, which is synthetized by the pks genomic island, was discovered in 2006. Despite many efforts, colibactin has not yet been purified, and its structure remains elusive. Interestingly, the pks island is found in members of the family Enterobacteriaceae (mainly Escherichia coli and Klebsiella pneumoniae) isolated from different origins, including from intestinal microbiota, septicaemia, newborn meningitis, and urinary tract infections. Colibactin-producing bacteria induce chromosomal instability and DNA damage in eukaryotic cells, which leads to senescence of epithelial cells and apoptosis of immune cells. The pks island is mainly observed in B2 phylogroup E. coli strains, which include extra-intestinal pathogenic E. coli strains, and pks E. coli are over-represented in biopsies isolated from colorectal cancer. In addition, pks E. coli bacteria increase the number of tumours in diverse colorectal cancer mouse models. Thus, colibactin could have a major impact on human health. In the present review, we will focus on the biological effects of colibactin, the distribution of the pks island, and summarize what is currently known about its synthesis and its structure. |
| first_indexed | 2024-04-14T01:03:23Z |
| format | Article |
| id | doaj.art-618d93b9f54c4de6ba46b42913c0b2f3 |
| institution | Directory Open Access Journal |
| issn | 2072-6651 |
| language | English |
| last_indexed | 2024-04-14T01:03:23Z |
| publishDate | 2018-04-01 |
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| spelling | doaj.art-618d93b9f54c4de6ba46b42913c0b2f32022-12-22T02:21:19ZengMDPI AGToxins2072-66512018-04-0110415110.3390/toxins10040151toxins10040151Colibactin: More Than a New Bacterial ToxinTiphanie Faïs0Julien Delmas1Nicolas Barnich2Richard Bonnet3Guillaume Dalmasso4Université Clermont Auvergne, Inserm U1071, M2iSH, USC-INRA 2018, F-63000 Clermont-Ferrand, FranceUniversité Clermont Auvergne, Inserm U1071, M2iSH, USC-INRA 2018, F-63000 Clermont-Ferrand, FranceUniversité Clermont Auvergne, Inserm U1071, M2iSH, USC-INRA 2018, F-63000 Clermont-Ferrand, FranceUniversité Clermont Auvergne, Inserm U1071, M2iSH, USC-INRA 2018, F-63000 Clermont-Ferrand, FranceUniversité Clermont Auvergne, Inserm U1071, M2iSH, USC-INRA 2018, F-63000 Clermont-Ferrand, FranceCyclomodulins are bacterial toxins that interfere with the eukaryotic cell cycle. A new cyclomodulin called colibactin, which is synthetized by the pks genomic island, was discovered in 2006. Despite many efforts, colibactin has not yet been purified, and its structure remains elusive. Interestingly, the pks island is found in members of the family Enterobacteriaceae (mainly Escherichia coli and Klebsiella pneumoniae) isolated from different origins, including from intestinal microbiota, septicaemia, newborn meningitis, and urinary tract infections. Colibactin-producing bacteria induce chromosomal instability and DNA damage in eukaryotic cells, which leads to senescence of epithelial cells and apoptosis of immune cells. The pks island is mainly observed in B2 phylogroup E. coli strains, which include extra-intestinal pathogenic E. coli strains, and pks E. coli are over-represented in biopsies isolated from colorectal cancer. In addition, pks E. coli bacteria increase the number of tumours in diverse colorectal cancer mouse models. Thus, colibactin could have a major impact on human health. In the present review, we will focus on the biological effects of colibactin, the distribution of the pks island, and summarize what is currently known about its synthesis and its structure.http://www.mdpi.com/2072-6651/10/4/151colibactinpksE. colicancertoxinmicrobiota |
| spellingShingle | Tiphanie Faïs Julien Delmas Nicolas Barnich Richard Bonnet Guillaume Dalmasso Colibactin: More Than a New Bacterial Toxin Toxins colibactin pks E. coli cancer toxin microbiota |
| title | Colibactin: More Than a New Bacterial Toxin |
| title_full | Colibactin: More Than a New Bacterial Toxin |
| title_fullStr | Colibactin: More Than a New Bacterial Toxin |
| title_full_unstemmed | Colibactin: More Than a New Bacterial Toxin |
| title_short | Colibactin: More Than a New Bacterial Toxin |
| title_sort | colibactin more than a new bacterial toxin |
| topic | colibactin pks E. coli cancer toxin microbiota |
| url | http://www.mdpi.com/2072-6651/10/4/151 |
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