Henoch–Schönlein Purpura (IgA Vasculitis) in Association with Thyrotoxicosis
Graves’ disease is the most common cause of hyperthyroidism, which is characterized by thyroid antibodies and the following clinical manifestations: goiter, ophthalmopathy, and pretibial myxedema. On the other hand, Henoch–Schönlein purpura is an IgA-mediated small-vessel vasculitis. Review of the l...
| Autori principali: | , , |
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| Natura: | Articolo |
| Lingua: | English |
| Pubblicazione: |
Wiley
2021-01-01
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| Serie: | Case Reports in Endocrinology |
| Accesso online: | http://dx.doi.org/10.1155/2021/6669653 |
| _version_ | 1826839985630740480 |
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| author | Mojgan Sanjari Mohammadreza Shakibi Moeinadin Safavi |
| author_facet | Mojgan Sanjari Mohammadreza Shakibi Moeinadin Safavi |
| author_sort | Mojgan Sanjari |
| collection | DOAJ |
| description | Graves’ disease is the most common cause of hyperthyroidism, which is characterized by thyroid antibodies and the following clinical manifestations: goiter, ophthalmopathy, and pretibial myxedema. On the other hand, Henoch–Schönlein purpura is an IgA-mediated small-vessel vasculitis. Review of the literature showed a relationship between propylthiouracil overdose and the following Henoch–Schönlein purpura (IgA vasculitis) as a side effect. The patient was a 31-year-old woman with a chief complaint of tremor and significant weight loss who contracted pruritic palpable purpura during her disease course. Then, she underwent the treatment of hyperthyroidism by methimazole which intensified her cutaneous lesions. The diagnosis of Henoch–Schönlein purpura (IgA vasculitis) was confirmed after skin biopsy. Finally, she was treated with colchicine, prednisolone, and radioiodine ablation, which caused her lesions to disappear. The temporal priority of pruritic palpable skin lesions to hyperthyroidism treatment with methimazole suggested that Henoch–Schönlein purpura (IgA vasculitis) was related to hyperthyroidism and was intensified by antithyroid agents in this patient. |
| first_indexed | 2025-02-16T12:32:34Z |
| format | Article |
| id | doaj.art-618d9af901b945af9961c6089fcf5731 |
| institution | Directory Open Access Journal |
| issn | 2090-6501 2090-651X |
| language | English |
| last_indexed | 2025-02-16T12:32:34Z |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Endocrinology |
| spelling | doaj.art-618d9af901b945af9961c6089fcf57312025-02-03T00:58:47ZengWileyCase Reports in Endocrinology2090-65012090-651X2021-01-01202110.1155/2021/66696536669653Henoch–Schönlein Purpura (IgA Vasculitis) in Association with ThyrotoxicosisMojgan Sanjari0Mohammadreza Shakibi1Moeinadin Safavi2Department of Endocrinology, Afzalipour Medical Faculty and Endocrinology and Metabolism Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, IranRheumatology Department, Afzalipour Medical Faculty and Physiology Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, IranPathology Department, School of Medicine, Kerman University of Medical Sciences, Kerman, IranGraves’ disease is the most common cause of hyperthyroidism, which is characterized by thyroid antibodies and the following clinical manifestations: goiter, ophthalmopathy, and pretibial myxedema. On the other hand, Henoch–Schönlein purpura is an IgA-mediated small-vessel vasculitis. Review of the literature showed a relationship between propylthiouracil overdose and the following Henoch–Schönlein purpura (IgA vasculitis) as a side effect. The patient was a 31-year-old woman with a chief complaint of tremor and significant weight loss who contracted pruritic palpable purpura during her disease course. Then, she underwent the treatment of hyperthyroidism by methimazole which intensified her cutaneous lesions. The diagnosis of Henoch–Schönlein purpura (IgA vasculitis) was confirmed after skin biopsy. Finally, she was treated with colchicine, prednisolone, and radioiodine ablation, which caused her lesions to disappear. The temporal priority of pruritic palpable skin lesions to hyperthyroidism treatment with methimazole suggested that Henoch–Schönlein purpura (IgA vasculitis) was related to hyperthyroidism and was intensified by antithyroid agents in this patient.http://dx.doi.org/10.1155/2021/6669653 |
| spellingShingle | Mojgan Sanjari Mohammadreza Shakibi Moeinadin Safavi Henoch–Schönlein Purpura (IgA Vasculitis) in Association with Thyrotoxicosis Case Reports in Endocrinology |
| title | Henoch–Schönlein Purpura (IgA Vasculitis) in Association with Thyrotoxicosis |
| title_full | Henoch–Schönlein Purpura (IgA Vasculitis) in Association with Thyrotoxicosis |
| title_fullStr | Henoch–Schönlein Purpura (IgA Vasculitis) in Association with Thyrotoxicosis |
| title_full_unstemmed | Henoch–Schönlein Purpura (IgA Vasculitis) in Association with Thyrotoxicosis |
| title_short | Henoch–Schönlein Purpura (IgA Vasculitis) in Association with Thyrotoxicosis |
| title_sort | henoch schonlein purpura iga vasculitis in association with thyrotoxicosis |
| url | http://dx.doi.org/10.1155/2021/6669653 |
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