Intraoperative Assessment and Photothermal Ablation of the Tumor Margins Using Gold Nanoparticles
Abstract Surgical resection is commonly used for therapeutic management of different solid tumors and is regarded as a primary standard of care procedure, but precise localization of tumor margins is a major intraoperative challenge. Herein, a generalized method by optimizing gold nanoparticles for...
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| Format: | Article |
| Language: | English |
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Wiley
2021-03-01
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| Series: | Advanced Science |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/advs.202002788 |
| _version_ | 1818676603974057984 |
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| author | Qiaolin Wei Hamed Arami Hélder A. Santos Hongbo Zhang Yangyang Li Jian He Danni Zhong Daishun Ling Min Zhou |
| author_facet | Qiaolin Wei Hamed Arami Hélder A. Santos Hongbo Zhang Yangyang Li Jian He Danni Zhong Daishun Ling Min Zhou |
| author_sort | Qiaolin Wei |
| collection | DOAJ |
| description | Abstract Surgical resection is commonly used for therapeutic management of different solid tumors and is regarded as a primary standard of care procedure, but precise localization of tumor margins is a major intraoperative challenge. Herein, a generalized method by optimizing gold nanoparticles for intraoperative detection and photothermal ablation of tumor margins is introduced. These nanoparticles are detectable by highly sensitive surface‐enhanced Raman scattering imaging. This non‐invasive technique assists in delineating the two surgically challenged tumors in live mice with orthotopic colon or ovarian tumors. Any remaining residual tumors are also ablated by using post‐surgical adjuvant photothermaltherapy (aPTT), which results in microscale heat generation due to interaction of these nanoparticles with near‐infrared laser. Ablation of these post‐operative residual micro‐tumors prolongs the survival of mice significantly and delays tumor recurrence by 15 days. To validate clinical translatability of this method, the pharmacokinetics, biodistribution, Raman contrast, aPTT efficiency, and toxicity of these nanoparticles are also investigated. The nanoparticles have long blood circulation time (≈24 h), high tumor accumulation (4.87 ± 1.73%ID g−1) and no toxicity. This high‐resolution and sensitive intraoperative approach is versatile and can be potentially used for targeted ablation of residual tumor after resection within different organs. |
| first_indexed | 2024-12-17T08:46:07Z |
| format | Article |
| id | doaj.art-618e15dc76514ed0aaf5dd66ab9415fa |
| institution | Directory Open Access Journal |
| issn | 2198-3844 |
| language | English |
| last_indexed | 2024-12-17T08:46:07Z |
| publishDate | 2021-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj.art-618e15dc76514ed0aaf5dd66ab9415fa2022-12-21T21:56:12ZengWileyAdvanced Science2198-38442021-03-0185n/an/a10.1002/advs.202002788Intraoperative Assessment and Photothermal Ablation of the Tumor Margins Using Gold NanoparticlesQiaolin Wei0Hamed Arami1Hélder A. Santos2Hongbo Zhang3Yangyang Li4Jian He5Danni Zhong6Daishun Ling7Min Zhou8The Fourth Affiliated Hospital Zhejiang University School of Medicine Yiwu 322000 P. R. ChinaMolecular Imaging Program at Stanford Department of Radiology Stanford University Stanford CA 94305‐5427 USADrug Research Program Division of Pharmaceutical Chemistry and Technology Faculty of Pharmacy University of Helsinki Helsinki FI‐00014 FinlandPharmaceutical Science Laboratory Åbo Akademi University Turku 20520 FinlandInstitute of Translational Medicine Zhejiang University Hangzhou 310009 P. R. ChinaInstitute of Translational Medicine Zhejiang University Hangzhou 310009 P. R. ChinaInstitute of Translational Medicine Zhejiang University Hangzhou 310009 P. R. ChinaInstitute of Pharmaceutics College of Pharmaceutical Sciences Zhejiang University Hangzhou Zhejiang 310058 P. R. ChinaThe Fourth Affiliated Hospital Zhejiang University School of Medicine Yiwu 322000 P. R. ChinaAbstract Surgical resection is commonly used for therapeutic management of different solid tumors and is regarded as a primary standard of care procedure, but precise localization of tumor margins is a major intraoperative challenge. Herein, a generalized method by optimizing gold nanoparticles for intraoperative detection and photothermal ablation of tumor margins is introduced. These nanoparticles are detectable by highly sensitive surface‐enhanced Raman scattering imaging. This non‐invasive technique assists in delineating the two surgically challenged tumors in live mice with orthotopic colon or ovarian tumors. Any remaining residual tumors are also ablated by using post‐surgical adjuvant photothermaltherapy (aPTT), which results in microscale heat generation due to interaction of these nanoparticles with near‐infrared laser. Ablation of these post‐operative residual micro‐tumors prolongs the survival of mice significantly and delays tumor recurrence by 15 days. To validate clinical translatability of this method, the pharmacokinetics, biodistribution, Raman contrast, aPTT efficiency, and toxicity of these nanoparticles are also investigated. The nanoparticles have long blood circulation time (≈24 h), high tumor accumulation (4.87 ± 1.73%ID g−1) and no toxicity. This high‐resolution and sensitive intraoperative approach is versatile and can be potentially used for targeted ablation of residual tumor after resection within different organs.https://doi.org/10.1002/advs.202002788gold nanoparticlesintraoperative assessmentphotothermal ablationsurface‐enhanced Raman scattering imagingtumor margins |
| spellingShingle | Qiaolin Wei Hamed Arami Hélder A. Santos Hongbo Zhang Yangyang Li Jian He Danni Zhong Daishun Ling Min Zhou Intraoperative Assessment and Photothermal Ablation of the Tumor Margins Using Gold Nanoparticles Advanced Science gold nanoparticles intraoperative assessment photothermal ablation surface‐enhanced Raman scattering imaging tumor margins |
| title | Intraoperative Assessment and Photothermal Ablation of the Tumor Margins Using Gold Nanoparticles |
| title_full | Intraoperative Assessment and Photothermal Ablation of the Tumor Margins Using Gold Nanoparticles |
| title_fullStr | Intraoperative Assessment and Photothermal Ablation of the Tumor Margins Using Gold Nanoparticles |
| title_full_unstemmed | Intraoperative Assessment and Photothermal Ablation of the Tumor Margins Using Gold Nanoparticles |
| title_short | Intraoperative Assessment and Photothermal Ablation of the Tumor Margins Using Gold Nanoparticles |
| title_sort | intraoperative assessment and photothermal ablation of the tumor margins using gold nanoparticles |
| topic | gold nanoparticles intraoperative assessment photothermal ablation surface‐enhanced Raman scattering imaging tumor margins |
| url | https://doi.org/10.1002/advs.202002788 |
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