Role of Fibulins in Embryonic Stage Development and Their Involvement in Various Diseases
The extracellular matrix (ECM) plays an important role in the evolution of early metazoans, as it provides structural and biochemical support to the surrounding cells through the cell–cell and cell–matrix interactions. In multi-cellular organisms, ECM plays a pivotal role in the differentiation of t...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-05-01
|
| Series: | Biomolecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2218-273X/11/5/685 |
| _version_ | 1797535360045023232 |
|---|---|
| author | Deviyani Mahajan Sudhakar Kancharla Prachetha Kolli Amarish Kumar Sharma Sanjeev Singh Sudarshan Kumar Ashok Kumar Mohanty Manoj Kumar Jena |
| author_facet | Deviyani Mahajan Sudhakar Kancharla Prachetha Kolli Amarish Kumar Sharma Sanjeev Singh Sudarshan Kumar Ashok Kumar Mohanty Manoj Kumar Jena |
| author_sort | Deviyani Mahajan |
| collection | DOAJ |
| description | The extracellular matrix (ECM) plays an important role in the evolution of early metazoans, as it provides structural and biochemical support to the surrounding cells through the cell–cell and cell–matrix interactions. In multi-cellular organisms, ECM plays a pivotal role in the differentiation of tissues and in the development of organs. Fibulins are ECM glycoproteins, found in a variety of tissues associated with basement membranes, elastic fibers, proteoglycan aggregates, and fibronectin microfibrils. The expression profile of fibulins reveals their role in various developmental processes such as elastogenesis, development of organs during the embryonic stage, tissue remodeling, maintenance of the structural integrity of basement membrane, and elastic fibers, as well as other cellular processes. Apart from this, fibulins are also involved in the progression of human diseases such as cancer, cardiac diseases, congenital disorders, and chronic fibrotic disorders. Different isoforms of fibulins show a dual role of tumor-suppressive and tumor-promoting activities, depending on the cell type and cellular microenvironment in the body. Knockout animal models have provided deep insight into their role in development and diseases. The present review covers details of the structural and expression patterns, along with the role of fibulins in embryonic development and disease progression, with more emphasis on their involvement in the modulation of cancer diseases. |
| first_indexed | 2024-03-10T11:44:16Z |
| format | Article |
| id | doaj.art-6190f692b7cc48a3aae8e03c025bf68e |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-10T11:44:16Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-6190f692b7cc48a3aae8e03c025bf68e2023-11-21T18:13:58ZengMDPI AGBiomolecules2218-273X2021-05-0111568510.3390/biom11050685Role of Fibulins in Embryonic Stage Development and Their Involvement in Various DiseasesDeviyani Mahajan0Sudhakar Kancharla1Prachetha Kolli2Amarish Kumar Sharma3Sanjeev Singh4Sudarshan Kumar5Ashok Kumar Mohanty6Manoj Kumar Jena7Department of Biotechnology, School of Bioengineering and Biosciences, Lovely Professional University, Phagwara, Punjab 144411, IndiaDevansh Lab Werks, 234 Aquarius Drive, Homewood, AL 35209, USAMicrogen Health Inc., 14225 Sullyfield Cir Suite E, Chantilly, VA 20151, USADepartment of Biotechnology, School of Bioengineering and Biosciences, Lovely Professional University, Phagwara, Punjab 144411, IndiaDepartment of Biotechnology, School of Bioengineering and Biosciences, Lovely Professional University, Phagwara, Punjab 144411, IndiaAnimal Biotechnology Centre, National Dairy Research Institute, Karnal, Haryana 132001, IndiaAnimal Biotechnology Centre, National Dairy Research Institute, Karnal, Haryana 132001, IndiaDepartment of Biotechnology, School of Bioengineering and Biosciences, Lovely Professional University, Phagwara, Punjab 144411, IndiaThe extracellular matrix (ECM) plays an important role in the evolution of early metazoans, as it provides structural and biochemical support to the surrounding cells through the cell–cell and cell–matrix interactions. In multi-cellular organisms, ECM plays a pivotal role in the differentiation of tissues and in the development of organs. Fibulins are ECM glycoproteins, found in a variety of tissues associated with basement membranes, elastic fibers, proteoglycan aggregates, and fibronectin microfibrils. The expression profile of fibulins reveals their role in various developmental processes such as elastogenesis, development of organs during the embryonic stage, tissue remodeling, maintenance of the structural integrity of basement membrane, and elastic fibers, as well as other cellular processes. Apart from this, fibulins are also involved in the progression of human diseases such as cancer, cardiac diseases, congenital disorders, and chronic fibrotic disorders. Different isoforms of fibulins show a dual role of tumor-suppressive and tumor-promoting activities, depending on the cell type and cellular microenvironment in the body. Knockout animal models have provided deep insight into their role in development and diseases. The present review covers details of the structural and expression patterns, along with the role of fibulins in embryonic development and disease progression, with more emphasis on their involvement in the modulation of cancer diseases.https://www.mdpi.com/2218-273X/11/5/685fibulinsembryonic stagecancerheritable disorders |
| spellingShingle | Deviyani Mahajan Sudhakar Kancharla Prachetha Kolli Amarish Kumar Sharma Sanjeev Singh Sudarshan Kumar Ashok Kumar Mohanty Manoj Kumar Jena Role of Fibulins in Embryonic Stage Development and Their Involvement in Various Diseases Biomolecules fibulins embryonic stage cancer heritable disorders |
| title | Role of Fibulins in Embryonic Stage Development and Their Involvement in Various Diseases |
| title_full | Role of Fibulins in Embryonic Stage Development and Their Involvement in Various Diseases |
| title_fullStr | Role of Fibulins in Embryonic Stage Development and Their Involvement in Various Diseases |
| title_full_unstemmed | Role of Fibulins in Embryonic Stage Development and Their Involvement in Various Diseases |
| title_short | Role of Fibulins in Embryonic Stage Development and Their Involvement in Various Diseases |
| title_sort | role of fibulins in embryonic stage development and their involvement in various diseases |
| topic | fibulins embryonic stage cancer heritable disorders |
| url | https://www.mdpi.com/2218-273X/11/5/685 |
| work_keys_str_mv | AT deviyanimahajan roleoffibulinsinembryonicstagedevelopmentandtheirinvolvementinvariousdiseases AT sudhakarkancharla roleoffibulinsinembryonicstagedevelopmentandtheirinvolvementinvariousdiseases AT prachethakolli roleoffibulinsinembryonicstagedevelopmentandtheirinvolvementinvariousdiseases AT amarishkumarsharma roleoffibulinsinembryonicstagedevelopmentandtheirinvolvementinvariousdiseases AT sanjeevsingh roleoffibulinsinembryonicstagedevelopmentandtheirinvolvementinvariousdiseases AT sudarshankumar roleoffibulinsinembryonicstagedevelopmentandtheirinvolvementinvariousdiseases AT ashokkumarmohanty roleoffibulinsinembryonicstagedevelopmentandtheirinvolvementinvariousdiseases AT manojkumarjena roleoffibulinsinembryonicstagedevelopmentandtheirinvolvementinvariousdiseases |