Androgen-Mediated Anti-inflammatory Cellular Processes as Therapeutic Targets in Lupus
Systemic Lupus Erythematosus (SLE), among many other auto-immune diseases, is known to be more prevalent in females than in males. This observation has served as the foundation for studies into how sex hormones may interact with the immune system to either drive or inhibit immune activation. Early s...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-06-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2020.01271/full |
| _version_ | 1811222058063888384 |
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| author | Jessica M. Jones Trine N. Jørgensen |
| author_facet | Jessica M. Jones Trine N. Jørgensen |
| author_sort | Jessica M. Jones |
| collection | DOAJ |
| description | Systemic Lupus Erythematosus (SLE), among many other auto-immune diseases, is known to be more prevalent in females than in males. This observation has served as the foundation for studies into how sex hormones may interact with the immune system to either drive or inhibit immune activation. Early studies using castration in lupus mouse models showed the potential protective effect of testosterone against lupus development. These studies were later corroborated by observational studies in lupus patients, who upon treatment with testosterone therapy, displayed decreased disease burden. However, there are numerous limitations to treating (especially female) lupus patients with testosterone. Thus, identification of testosterone-targeted cellular and molecular mechanisms affecting immune activation is an attractive target for lupus treatment in the future. Recent studies have examined the effects of androgens on the activation of anti-inflammatory processes. As such, immunoregulatory cell types including myeloid-derived suppressor cells (MDSCs) and regulatory T and B cells have been shown to be susceptible to manipulation by sex hormones. Here, we review studies of SLE and lupus-like disease in which testosterone or testosterone-derivatives were used to skew an ongoing immune reaction toward an anti-inflammatory state. Via evaluation of both clinical studies and immunologic models we propose new areas for research with the goal of identifying testosterone-driven anti-inflammatory mediators suitable for therapeutic targeting in patients with lupus and other autoimmune diseases. |
| first_indexed | 2024-04-12T08:10:08Z |
| format | Article |
| id | doaj.art-6191390792084fbba2bc1023e608f6d3 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-12T08:10:08Z |
| publishDate | 2020-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-6191390792084fbba2bc1023e608f6d32022-12-22T03:41:01ZengFrontiers Media S.A.Frontiers in Immunology1664-32242020-06-011110.3389/fimmu.2020.01271540668Androgen-Mediated Anti-inflammatory Cellular Processes as Therapeutic Targets in LupusJessica M. Jones0Trine N. Jørgensen1Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, United StatesDepartment of Inflammation and Immunity, Cleveland Clinic, Lerner Research Institute, Cleveland, OH, United StatesSystemic Lupus Erythematosus (SLE), among many other auto-immune diseases, is known to be more prevalent in females than in males. This observation has served as the foundation for studies into how sex hormones may interact with the immune system to either drive or inhibit immune activation. Early studies using castration in lupus mouse models showed the potential protective effect of testosterone against lupus development. These studies were later corroborated by observational studies in lupus patients, who upon treatment with testosterone therapy, displayed decreased disease burden. However, there are numerous limitations to treating (especially female) lupus patients with testosterone. Thus, identification of testosterone-targeted cellular and molecular mechanisms affecting immune activation is an attractive target for lupus treatment in the future. Recent studies have examined the effects of androgens on the activation of anti-inflammatory processes. As such, immunoregulatory cell types including myeloid-derived suppressor cells (MDSCs) and regulatory T and B cells have been shown to be susceptible to manipulation by sex hormones. Here, we review studies of SLE and lupus-like disease in which testosterone or testosterone-derivatives were used to skew an ongoing immune reaction toward an anti-inflammatory state. Via evaluation of both clinical studies and immunologic models we propose new areas for research with the goal of identifying testosterone-driven anti-inflammatory mediators suitable for therapeutic targeting in patients with lupus and other autoimmune diseases.https://www.frontiersin.org/article/10.3389/fimmu.2020.01271/fullSLElupusandrogenMDSCpDC |
| spellingShingle | Jessica M. Jones Trine N. Jørgensen Androgen-Mediated Anti-inflammatory Cellular Processes as Therapeutic Targets in Lupus Frontiers in Immunology SLE lupus androgen MDSC pDC |
| title | Androgen-Mediated Anti-inflammatory Cellular Processes as Therapeutic Targets in Lupus |
| title_full | Androgen-Mediated Anti-inflammatory Cellular Processes as Therapeutic Targets in Lupus |
| title_fullStr | Androgen-Mediated Anti-inflammatory Cellular Processes as Therapeutic Targets in Lupus |
| title_full_unstemmed | Androgen-Mediated Anti-inflammatory Cellular Processes as Therapeutic Targets in Lupus |
| title_short | Androgen-Mediated Anti-inflammatory Cellular Processes as Therapeutic Targets in Lupus |
| title_sort | androgen mediated anti inflammatory cellular processes as therapeutic targets in lupus |
| topic | SLE lupus androgen MDSC pDC |
| url | https://www.frontiersin.org/article/10.3389/fimmu.2020.01271/full |
| work_keys_str_mv | AT jessicamjones androgenmediatedantiinflammatorycellularprocessesastherapeutictargetsinlupus AT trinenjørgensen androgenmediatedantiinflammatorycellularprocessesastherapeutictargetsinlupus |