Synthesis and Characterization of Abasic β-Diol-<i>C</i>-nucleosides
Modified nucleobases are potentially useful building blocks when containing catalytically active functionalities and could be introduced in chiral tridimensional molecules such as nucleic acids, which creates the premises for the development of novel catalytic species. Herein, we describe the synthe...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-05-01
|
| Series: | Chemistry |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2624-8549/5/2/91 |
| _version_ | 1797595528954904576 |
|---|---|
| author | Maria Moccia Linda Piras Gea Bellini Michele Saviano Mauro F. A. Adamo |
| author_facet | Maria Moccia Linda Piras Gea Bellini Michele Saviano Mauro F. A. Adamo |
| author_sort | Maria Moccia |
| collection | DOAJ |
| description | Modified nucleobases are potentially useful building blocks when containing catalytically active functionalities and could be introduced in chiral tridimensional molecules such as nucleic acids, which creates the premises for the development of novel catalytic species. Herein, we describe the synthesis of a novel β-<i>C</i>-nucleoside bearing a diol group at anomeric position, amenable as a metal ligand or organocatalyst. An abasic ligand was successfully prepared and inserted into a complementary DNA strand. |
| first_indexed | 2024-03-11T02:38:48Z |
| format | Article |
| id | doaj.art-61917a41c1bb4486932d0312fdb96ccb |
| institution | Directory Open Access Journal |
| issn | 2624-8549 |
| language | English |
| last_indexed | 2024-03-11T02:38:48Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Chemistry |
| spelling | doaj.art-61917a41c1bb4486932d0312fdb96ccb2023-11-18T09:45:46ZengMDPI AGChemistry2624-85492023-05-01521343135610.3390/chemistry5020091Synthesis and Characterization of Abasic β-Diol-<i>C</i>-nucleosidesMaria Moccia0Linda Piras1Gea Bellini2Michele Saviano3Mauro F. A. Adamo4Department of Chemistry, National Research Council-Institute of Crystallography, Via G. Amendola 122/O, 70126 Bari, ItalyCentre for Synthesis and Chemical Biology (CSCB), Department of Chemistry, Royal College of Surgeons in Ireland, 123 St. Stephen’s Green, D02 YN77 Dublin 2, IrelandCentre for Synthesis and Chemical Biology (CSCB), Department of Chemistry, Royal College of Surgeons in Ireland, 123 St. Stephen’s Green, D02 YN77 Dublin 2, IrelandDepartment of Chemistry, National Research Council-Institute of Crystallography, Via G. Amendola 122/O, 70126 Bari, ItalyCentre for Synthesis and Chemical Biology (CSCB), Department of Chemistry, Royal College of Surgeons in Ireland, 123 St. Stephen’s Green, D02 YN77 Dublin 2, IrelandModified nucleobases are potentially useful building blocks when containing catalytically active functionalities and could be introduced in chiral tridimensional molecules such as nucleic acids, which creates the premises for the development of novel catalytic species. Herein, we describe the synthesis of a novel β-<i>C</i>-nucleoside bearing a diol group at anomeric position, amenable as a metal ligand or organocatalyst. An abasic ligand was successfully prepared and inserted into a complementary DNA strand.https://www.mdpi.com/2624-8549/5/2/91<i>C</i>-nucleosidesabasic nucleosidesfunctionalized DNAs |
| spellingShingle | Maria Moccia Linda Piras Gea Bellini Michele Saviano Mauro F. A. Adamo Synthesis and Characterization of Abasic β-Diol-<i>C</i>-nucleosides Chemistry <i>C</i>-nucleosides abasic nucleosides functionalized DNAs |
| title | Synthesis and Characterization of Abasic β-Diol-<i>C</i>-nucleosides |
| title_full | Synthesis and Characterization of Abasic β-Diol-<i>C</i>-nucleosides |
| title_fullStr | Synthesis and Characterization of Abasic β-Diol-<i>C</i>-nucleosides |
| title_full_unstemmed | Synthesis and Characterization of Abasic β-Diol-<i>C</i>-nucleosides |
| title_short | Synthesis and Characterization of Abasic β-Diol-<i>C</i>-nucleosides |
| title_sort | synthesis and characterization of abasic β diol i c i nucleosides |
| topic | <i>C</i>-nucleosides abasic nucleosides functionalized DNAs |
| url | https://www.mdpi.com/2624-8549/5/2/91 |
| work_keys_str_mv | AT mariamoccia synthesisandcharacterizationofabasicbdiolicinucleosides AT lindapiras synthesisandcharacterizationofabasicbdiolicinucleosides AT geabellini synthesisandcharacterizationofabasicbdiolicinucleosides AT michelesaviano synthesisandcharacterizationofabasicbdiolicinucleosides AT maurofaadamo synthesisandcharacterizationofabasicbdiolicinucleosides |