Cerebrospinal Fluid Levels of Neopterin in Child Patients with Neurological Diseases-In Correlation with IFN-γ or TNF-α
Cerebrospinal fluid (CSF) neopterin levels were measured in child patients with neurological diseases. CSF neopterin levels on admission were significantly higher in patients with bacterial meningitis than in those with aseptic meningitis or in those with non-pleocytotic CSF. CSF neopterin levels in...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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De Gruyter
1999-02-01
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| Series: | Pteridines |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/pteridines.1999.10.1.27 |
| _version_ | 1819031245478166528 |
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| author | Kawakami Yasuhiko Fukunaga Yoshitaka Kuwabara Kentaro Fujita Takehisa Fujino Osamu Hashimoto Kiyoshi |
| author_facet | Kawakami Yasuhiko Fukunaga Yoshitaka Kuwabara Kentaro Fujita Takehisa Fujino Osamu Hashimoto Kiyoshi |
| author_sort | Kawakami Yasuhiko |
| collection | DOAJ |
| description | Cerebrospinal fluid (CSF) neopterin levels were measured in child patients with neurological diseases. CSF neopterin levels on admission were significantly higher in patients with bacterial meningitis than in those with aseptic meningitis or in those with non-pleocytotic CSF. CSF neopterin levels in patients with bacterial meningitis one day after admission were higher than those on admission and were markedly elevated with high levels of CSF IFN-γ and TNF-α. CSF neopterin levels in patients with bacterial meningitis one day after admission were related to the period of positive serum C-reactive protein. In patients with non-pleocytotic CSF, CSF neopterin and CSF IFN-y levels were higher in patients with febrile convulsion (FC) than in those with pyrexia only or convulsion (including epilepsy) only. These results suggest that elevation of CSF neopterin in bacterial meningitis results from monocytes/ macrophages costimulated with IFN-γ and TNF-α and that immunological activation in the central nervous system is one of the mechanisms of onset with FC. |
| first_indexed | 2024-12-21T06:42:59Z |
| format | Article |
| id | doaj.art-6191a9cf377b49a39bbc257f3d008b72 |
| institution | Directory Open Access Journal |
| issn | 0933-4807 2195-4720 |
| language | English |
| last_indexed | 2024-12-21T06:42:59Z |
| publishDate | 1999-02-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Pteridines |
| spelling | doaj.art-6191a9cf377b49a39bbc257f3d008b722022-12-21T19:12:39ZengDe GruyterPteridines0933-48072195-47201999-02-01101273110.1515/pteridines.1999.10.1.27Cerebrospinal Fluid Levels of Neopterin in Child Patients with Neurological Diseases-In Correlation with IFN-γ or TNF-αKawakami Yasuhiko0Fukunaga Yoshitaka1Kuwabara Kentaro2Fujita Takehisa3Fujino Osamu4Hashimoto Kiyoshi5Nippon Medical School Second Hospital, Department of Pediatrics, 1-396, Kosugi, Nakahara-ku, Kawasaki city, Kanagawa 211-8533, JapanNippon Medical School Main Hospital, Department of Pediatrics, 1-1-5, Sendagi, Bunkyo-ku, Tokyo 113-8603, JapanNippon Medical School Second Hospital, Department of Pediatrics, 1-396, Kosugi, Nakahara-ku, Kawasaki city, Kanagawa 211-8533, JapanNippon Medical School Second Hospital, Department of Pediatrics, 1-396, Kosugi, Nakahara-ku, Kawasaki city, Kanagawa 211-8533, JapanNippon Medical School Second Hospital, Department of Pediatrics, 1-396, Kosugi, Nakahara-ku, Kawasaki city, Kanagawa 211-8533, JapanNippon Medical School Second Hospital, Department of Pediatrics, 1-396, Kosugi, Nakahara-ku, Kawasaki city, Kanagawa 211-8533, JapanCerebrospinal fluid (CSF) neopterin levels were measured in child patients with neurological diseases. CSF neopterin levels on admission were significantly higher in patients with bacterial meningitis than in those with aseptic meningitis or in those with non-pleocytotic CSF. CSF neopterin levels in patients with bacterial meningitis one day after admission were higher than those on admission and were markedly elevated with high levels of CSF IFN-γ and TNF-α. CSF neopterin levels in patients with bacterial meningitis one day after admission were related to the period of positive serum C-reactive protein. In patients with non-pleocytotic CSF, CSF neopterin and CSF IFN-y levels were higher in patients with febrile convulsion (FC) than in those with pyrexia only or convulsion (including epilepsy) only. These results suggest that elevation of CSF neopterin in bacterial meningitis results from monocytes/ macrophages costimulated with IFN-γ and TNF-α and that immunological activation in the central nervous system is one of the mechanisms of onset with FC.https://doi.org/10.1515/pteridines.1999.10.1.27neopterincerebrospinal fluid (csf)bacterial meningitisnon-pheocytotic csffebrile convulsion (fc) |
| spellingShingle | Kawakami Yasuhiko Fukunaga Yoshitaka Kuwabara Kentaro Fujita Takehisa Fujino Osamu Hashimoto Kiyoshi Cerebrospinal Fluid Levels of Neopterin in Child Patients with Neurological Diseases-In Correlation with IFN-γ or TNF-α Pteridines neopterin cerebrospinal fluid (csf) bacterial meningitis non-pheocytotic csf febrile convulsion (fc) |
| title | Cerebrospinal Fluid Levels of Neopterin in Child Patients with Neurological Diseases-In Correlation with IFN-γ or TNF-α |
| title_full | Cerebrospinal Fluid Levels of Neopterin in Child Patients with Neurological Diseases-In Correlation with IFN-γ or TNF-α |
| title_fullStr | Cerebrospinal Fluid Levels of Neopterin in Child Patients with Neurological Diseases-In Correlation with IFN-γ or TNF-α |
| title_full_unstemmed | Cerebrospinal Fluid Levels of Neopterin in Child Patients with Neurological Diseases-In Correlation with IFN-γ or TNF-α |
| title_short | Cerebrospinal Fluid Levels of Neopterin in Child Patients with Neurological Diseases-In Correlation with IFN-γ or TNF-α |
| title_sort | cerebrospinal fluid levels of neopterin in child patients with neurological diseases in correlation with ifn γ or tnf α |
| topic | neopterin cerebrospinal fluid (csf) bacterial meningitis non-pheocytotic csf febrile convulsion (fc) |
| url | https://doi.org/10.1515/pteridines.1999.10.1.27 |
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