JUVENILE CHRONIC ARTHRITIS WITH EYE LESION
A bstract. Objective, to describe a series of pts with JRA/JCA and uveitis. Material and methods. The study included 81 pts with JRA and uveitis. There were 68 girls-84%, 13 boys-16%. We studied the clinical manifestations, the antinuclear antibodies (ANA) using HEP-2 cells for the 33 pts with uveit...
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| Format: | Article |
| Language: | Russian |
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IMA PRESS LLC
2002-02-01
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| Series: | Научно-практическая ревматология |
| Subjects: | |
| Online Access: | https://rsp.mediar-press.net/rsp/article/view/884 |
| _version_ | 1797863055751643136 |
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| author | S O Salugina N N Kuzmina A L Speransky I A Guseva S. M. Ivanova |
| author_facet | S O Salugina N N Kuzmina A L Speransky I A Guseva S. M. Ivanova |
| author_sort | S O Salugina |
| collection | DOAJ |
| description | A bstract. Objective, to describe a series of pts with JRA/JCA and uveitis. Material and methods. The study included 81 pts with JRA and uveitis. There were 68 girls-84%, 13 boys-16%. We studied the clinical manifestations, the antinuclear antibodies (ANA) using HEP-2 cells for the 33 pts with uveitis and 46 pts without uveitis, HLA status was determined for 36 pts. Results. 85,2% of the children had arthritis before uveitis. The mean age at onset of arthritis was 3,5 year (range: 1-10 yrs), the mean age at onset of uveitis was 6 year (range: 2-15 yrs). The mean interval between the onset of arthritis and uveitis was 3,02 years (range: 3,5 yrs before arthritis onset to 12,5 yrs after). In 68,1% pts the diagnosis of uveitis was made within 5 yrs after onset of arthritis. 93% of pts had mono-oligoarticular onset, but 50% had poliarticular course. 23,5% of pts had functional disability 3-4 classes. Ocular complications were developed in 53.1%: cataracts-38,3%, band keratopathy-11,1%, glaucoma-2,5%. 93,9% of 33 studied children with arthritis and uveitis were ANA positive, 9,1% were RF positive. 18,1 % had HLA-DR8 (p<0,001), 83,3% - HLA-A2 (p<0,00l), HLA-B27 - 30,6 % (p<0,00l). Conclusion. Clinical and laboratory data of our pts suggest that: l)the combination of arthritis and uveitis would be named JCA with uveitis; 2) according our opinion JCA with uveitis is separate nosological form among the juvenile arthritides. |
| first_indexed | 2024-04-09T22:29:26Z |
| format | Article |
| id | doaj.art-619307aaf46d43bdbc068e886e719a51 |
| institution | Directory Open Access Journal |
| issn | 1995-4484 1995-4492 |
| language | Russian |
| last_indexed | 2024-04-09T22:29:26Z |
| publishDate | 2002-02-01 |
| publisher | IMA PRESS LLC |
| record_format | Article |
| series | Научно-практическая ревматология |
| spelling | doaj.art-619307aaf46d43bdbc068e886e719a512023-03-22T13:45:37ZrusIMA PRESS LLCНаучно-практическая ревматология1995-44841995-44922002-02-01401354010.14412/1995-4484-2002-747824JUVENILE CHRONIC ARTHRITIS WITH EYE LESIONS O SaluginaN N KuzminaA L SperanskyI A GusevaS. M. IvanovaA bstract. Objective, to describe a series of pts with JRA/JCA and uveitis. Material and methods. The study included 81 pts with JRA and uveitis. There were 68 girls-84%, 13 boys-16%. We studied the clinical manifestations, the antinuclear antibodies (ANA) using HEP-2 cells for the 33 pts with uveitis and 46 pts without uveitis, HLA status was determined for 36 pts. Results. 85,2% of the children had arthritis before uveitis. The mean age at onset of arthritis was 3,5 year (range: 1-10 yrs), the mean age at onset of uveitis was 6 year (range: 2-15 yrs). The mean interval between the onset of arthritis and uveitis was 3,02 years (range: 3,5 yrs before arthritis onset to 12,5 yrs after). In 68,1% pts the diagnosis of uveitis was made within 5 yrs after onset of arthritis. 93% of pts had mono-oligoarticular onset, but 50% had poliarticular course. 23,5% of pts had functional disability 3-4 classes. Ocular complications were developed in 53.1%: cataracts-38,3%, band keratopathy-11,1%, glaucoma-2,5%. 93,9% of 33 studied children with arthritis and uveitis were ANA positive, 9,1% were RF positive. 18,1 % had HLA-DR8 (p<0,001), 83,3% - HLA-A2 (p<0,00l), HLA-B27 - 30,6 % (p<0,00l). Conclusion. Clinical and laboratory data of our pts suggest that: l)the combination of arthritis and uveitis would be named JCA with uveitis; 2) according our opinion JCA with uveitis is separate nosological form among the juvenile arthritides.https://rsp.mediar-press.net/rsp/article/view/884juvenile rheumatoid arthritisjuvenile chronic arthritisjuvenile idionalhic arthritisuveitis |
| spellingShingle | S O Salugina N N Kuzmina A L Speransky I A Guseva S. M. Ivanova JUVENILE CHRONIC ARTHRITIS WITH EYE LESION Научно-практическая ревматология juvenile rheumatoid arthritis juvenile chronic arthritis juvenile idionalhic arthritis uveitis |
| title | JUVENILE CHRONIC ARTHRITIS WITH EYE LESION |
| title_full | JUVENILE CHRONIC ARTHRITIS WITH EYE LESION |
| title_fullStr | JUVENILE CHRONIC ARTHRITIS WITH EYE LESION |
| title_full_unstemmed | JUVENILE CHRONIC ARTHRITIS WITH EYE LESION |
| title_short | JUVENILE CHRONIC ARTHRITIS WITH EYE LESION |
| title_sort | juvenile chronic arthritis with eye lesion |
| topic | juvenile rheumatoid arthritis juvenile chronic arthritis juvenile idionalhic arthritis uveitis |
| url | https://rsp.mediar-press.net/rsp/article/view/884 |
| work_keys_str_mv | AT sosalugina juvenilechronicarthritiswitheyelesion AT nnkuzmina juvenilechronicarthritiswitheyelesion AT alsperansky juvenilechronicarthritiswitheyelesion AT iaguseva juvenilechronicarthritiswitheyelesion AT smivanova juvenilechronicarthritiswitheyelesion |