A Broad Spectrum Chemokine Inhibitor Prevents Preterm Labor but Not Microbial Invasion of the Amniotic Cavity or Neonatal Morbidity in a Non-human Primate Model

A Broad Spectrum Chemokine Inhibitor Prevents Preterm Labor but Not Microbial Invasion of the Amniotic Cavity or Neonatal Morbidity in a Non-human Primate Model

Leukocyte activation within the chorioamniotic membranes is strongly associated with inflammation and preterm labor (PTL). We hypothesized that prophylaxis with a broad-spectrum chemokine inhibitor (BSCI) would downregulate the inflammatory microenvironment induced by Group B Streptococcus (GBS, Str...

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Bibliographic Details
Main Authors: Michelle Coleman, Austyn Orvis, Tsung-Yen Wu, Matthew Dacanay, Sean Merillat, Jason Ogle, Audrey Baldessari, Nicole M. Kretzer, Jeff Munson, Adam J. Boros-Rausch, Oksana Shynlova, Stephen Lye, Lakshmi Rajagopal, Kristina M. Adams Waldorf
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Immunology
Subjects:
chorioamniotic membranes
placenta
neutrophil
chemokine
infection
fetus
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00770/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.00770/full

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