Brominated Depsidones with Antibacterial Effects from a Deep-Sea-Derived Fungus <i>Spiromastix</i> sp.
Eleven new brominated depsidones, namely spiromastixones U-Z5 (<b>1</b>–<b>11</b>) along with five known analogues (<b>12</b>–<b>16</b>), were isolated from a deep-sea-derived fungus <i>Spiromastix</i> sp. through the addition of sodium bro...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-02-01
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| Series: | Marine Drugs |
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| Online Access: | https://www.mdpi.com/1660-3397/22/2/78 |
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| author | Zequan Huang Dong Liu Shang Chen Jinwei Ren Chenghai Gao Zhiyong Li Aili Fan Wenhan Lin |
| author_facet | Zequan Huang Dong Liu Shang Chen Jinwei Ren Chenghai Gao Zhiyong Li Aili Fan Wenhan Lin |
| author_sort | Zequan Huang |
| collection | DOAJ |
| description | Eleven new brominated depsidones, namely spiromastixones U-Z5 (<b>1</b>–<b>11</b>) along with five known analogues (<b>12</b>–<b>16</b>), were isolated from a deep-sea-derived fungus <i>Spiromastix</i> sp. through the addition of sodium bromide during fermentation. Their structures were elucidated by extensive analysis of the spectroscopic data including high-resolution MS and 1D and 2D NMR data. Compounds <b>6</b>–<b>10</b> and <b>16</b> exhibited significant inhibition against Gram-positive bacteria including methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) and vancomycin-resistant <i>Enterococcus faecium</i> (VRE) with MIC values ranging from 0.5 to 2.0 μM. Particularly, tribrominated <b>7</b> displayed the strongest activity against MRSA and VRE with a MIC of 0.5 and 1.0 μM, respectively, suggesting its potential for further development as a new antibacterial agent. |
| first_indexed | 2024-03-07T22:23:46Z |
| format | Article |
| id | doaj.art-619463815c744a3eb2bde063c131b7b3 |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-03-07T22:23:46Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-619463815c744a3eb2bde063c131b7b32024-02-23T15:25:16ZengMDPI AGMarine Drugs1660-33972024-02-012227810.3390/md22020078Brominated Depsidones with Antibacterial Effects from a Deep-Sea-Derived Fungus <i>Spiromastix</i> sp.Zequan Huang0Dong Liu1Shang Chen2Jinwei Ren3Chenghai Gao4Zhiyong Li5Aili Fan6Wenhan Lin7State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, ChinaState Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, ChinaState Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, ChinaState Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, ChinaInstitute of Marine Drugs, Guangxi University of Chinese Medicine, Nanning 530200, ChinaState Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, ChinaState Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, ChinaState Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, ChinaEleven new brominated depsidones, namely spiromastixones U-Z5 (<b>1</b>–<b>11</b>) along with five known analogues (<b>12</b>–<b>16</b>), were isolated from a deep-sea-derived fungus <i>Spiromastix</i> sp. through the addition of sodium bromide during fermentation. Their structures were elucidated by extensive analysis of the spectroscopic data including high-resolution MS and 1D and 2D NMR data. Compounds <b>6</b>–<b>10</b> and <b>16</b> exhibited significant inhibition against Gram-positive bacteria including methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) and vancomycin-resistant <i>Enterococcus faecium</i> (VRE) with MIC values ranging from 0.5 to 2.0 μM. Particularly, tribrominated <b>7</b> displayed the strongest activity against MRSA and VRE with a MIC of 0.5 and 1.0 μM, respectively, suggesting its potential for further development as a new antibacterial agent.https://www.mdpi.com/1660-3397/22/2/78fungus<i>Spiromastix</i> sp.brominated depsidoneantibacterial effects |
| spellingShingle | Zequan Huang Dong Liu Shang Chen Jinwei Ren Chenghai Gao Zhiyong Li Aili Fan Wenhan Lin Brominated Depsidones with Antibacterial Effects from a Deep-Sea-Derived Fungus <i>Spiromastix</i> sp. Marine Drugs fungus <i>Spiromastix</i> sp. brominated depsidone antibacterial effects |
| title | Brominated Depsidones with Antibacterial Effects from a Deep-Sea-Derived Fungus <i>Spiromastix</i> sp. |
| title_full | Brominated Depsidones with Antibacterial Effects from a Deep-Sea-Derived Fungus <i>Spiromastix</i> sp. |
| title_fullStr | Brominated Depsidones with Antibacterial Effects from a Deep-Sea-Derived Fungus <i>Spiromastix</i> sp. |
| title_full_unstemmed | Brominated Depsidones with Antibacterial Effects from a Deep-Sea-Derived Fungus <i>Spiromastix</i> sp. |
| title_short | Brominated Depsidones with Antibacterial Effects from a Deep-Sea-Derived Fungus <i>Spiromastix</i> sp. |
| title_sort | brominated depsidones with antibacterial effects from a deep sea derived fungus i spiromastix i sp |
| topic | fungus <i>Spiromastix</i> sp. brominated depsidone antibacterial effects |
| url | https://www.mdpi.com/1660-3397/22/2/78 |
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