Phenytoin-induced cerebellar atrophy: A case for reversibility of neurological decline
This case serves as a reminder of the infrequent, yet consequential occurrence of cerebellar degeneration linked to phenytoin usage. Whilst emphasizes the importance of monitoring patients on long-term phenytoin therapy, and it further suggests considering employing bedside imaging tools such as Ult...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-01-01
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| Series: | Radiology Case Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1930043323008099 |
| _version_ | 1797454624787005440 |
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| author | Edwin Mogere Davis Cheruiyot Manakhe Nassiuma |
| author_facet | Edwin Mogere Davis Cheruiyot Manakhe Nassiuma |
| author_sort | Edwin Mogere |
| collection | DOAJ |
| description | This case serves as a reminder of the infrequent, yet consequential occurrence of cerebellar degeneration linked to phenytoin usage. Whilst emphasizes the importance of monitoring patients on long-term phenytoin therapy, and it further suggests considering employing bedside imaging tools such as Ultrasound fusion imaging for follow-up of patients at risk of this type of disorder. We present a case study involving a 23-year-old woman who experienced significant neurological impairment resulting in severe cerebellar atrophy while undergoing phenytoin treatment. On cessation of phenytoin, the patient exhibited improvement with enhanced cerebellar function. |
| first_indexed | 2024-03-09T15:40:50Z |
| format | Article |
| id | doaj.art-61966f0fb1da401483efb545f75e18c0 |
| institution | Directory Open Access Journal |
| issn | 1930-0433 |
| language | English |
| last_indexed | 2024-03-09T15:40:50Z |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Radiology Case Reports |
| spelling | doaj.art-61966f0fb1da401483efb545f75e18c02023-11-25T04:47:38ZengElsevierRadiology Case Reports1930-04332024-01-01191442444Phenytoin-induced cerebellar atrophy: A case for reversibility of neurological declineEdwin Mogere0Davis Cheruiyot1Manakhe Nassiuma2Section of Neurosurgery, Department of Surgery, Aga Khan University Hospital, Nairobi, Kenya; Corresponding author.Department of Neurosurgery, Moi Teaching and Referral Hospital, Eldoret, KenyaSection of Neurosurgery, Department of Surgery, Aga Khan University Hospital, Nairobi, KenyaThis case serves as a reminder of the infrequent, yet consequential occurrence of cerebellar degeneration linked to phenytoin usage. Whilst emphasizes the importance of monitoring patients on long-term phenytoin therapy, and it further suggests considering employing bedside imaging tools such as Ultrasound fusion imaging for follow-up of patients at risk of this type of disorder. We present a case study involving a 23-year-old woman who experienced significant neurological impairment resulting in severe cerebellar atrophy while undergoing phenytoin treatment. On cessation of phenytoin, the patient exhibited improvement with enhanced cerebellar function.http://www.sciencedirect.com/science/article/pii/S1930043323008099AnticonvulsantAtaxiaApoptosisDrug-Related side effects and adverse reactionsNystagmusPathologic |
| spellingShingle | Edwin Mogere Davis Cheruiyot Manakhe Nassiuma Phenytoin-induced cerebellar atrophy: A case for reversibility of neurological decline Radiology Case Reports Anticonvulsant Ataxia Apoptosis Drug-Related side effects and adverse reactions Nystagmus Pathologic |
| title | Phenytoin-induced cerebellar atrophy: A case for reversibility of neurological decline |
| title_full | Phenytoin-induced cerebellar atrophy: A case for reversibility of neurological decline |
| title_fullStr | Phenytoin-induced cerebellar atrophy: A case for reversibility of neurological decline |
| title_full_unstemmed | Phenytoin-induced cerebellar atrophy: A case for reversibility of neurological decline |
| title_short | Phenytoin-induced cerebellar atrophy: A case for reversibility of neurological decline |
| title_sort | phenytoin induced cerebellar atrophy a case for reversibility of neurological decline |
| topic | Anticonvulsant Ataxia Apoptosis Drug-Related side effects and adverse reactions Nystagmus Pathologic |
| url | http://www.sciencedirect.com/science/article/pii/S1930043323008099 |
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