Phenytoin-induced cerebellar atrophy: A case for reversibility of neurological decline
This case serves as a reminder of the infrequent, yet consequential occurrence of cerebellar degeneration linked to phenytoin usage. Whilst emphasizes the importance of monitoring patients on long-term phenytoin therapy, and it further suggests considering employing bedside imaging tools such as Ult...
Main Authors: | , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2024-01-01
|
Series: | Radiology Case Reports |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S1930043323008099 |
_version_ | 1797454624787005440 |
---|---|
author | Edwin Mogere Davis Cheruiyot Manakhe Nassiuma |
author_facet | Edwin Mogere Davis Cheruiyot Manakhe Nassiuma |
author_sort | Edwin Mogere |
collection | DOAJ |
description | This case serves as a reminder of the infrequent, yet consequential occurrence of cerebellar degeneration linked to phenytoin usage. Whilst emphasizes the importance of monitoring patients on long-term phenytoin therapy, and it further suggests considering employing bedside imaging tools such as Ultrasound fusion imaging for follow-up of patients at risk of this type of disorder. We present a case study involving a 23-year-old woman who experienced significant neurological impairment resulting in severe cerebellar atrophy while undergoing phenytoin treatment. On cessation of phenytoin, the patient exhibited improvement with enhanced cerebellar function. |
first_indexed | 2024-03-09T15:40:50Z |
format | Article |
id | doaj.art-61966f0fb1da401483efb545f75e18c0 |
institution | Directory Open Access Journal |
issn | 1930-0433 |
language | English |
last_indexed | 2024-03-09T15:40:50Z |
publishDate | 2024-01-01 |
publisher | Elsevier |
record_format | Article |
series | Radiology Case Reports |
spelling | doaj.art-61966f0fb1da401483efb545f75e18c02023-11-25T04:47:38ZengElsevierRadiology Case Reports1930-04332024-01-01191442444Phenytoin-induced cerebellar atrophy: A case for reversibility of neurological declineEdwin Mogere0Davis Cheruiyot1Manakhe Nassiuma2Section of Neurosurgery, Department of Surgery, Aga Khan University Hospital, Nairobi, Kenya; Corresponding author.Department of Neurosurgery, Moi Teaching and Referral Hospital, Eldoret, KenyaSection of Neurosurgery, Department of Surgery, Aga Khan University Hospital, Nairobi, KenyaThis case serves as a reminder of the infrequent, yet consequential occurrence of cerebellar degeneration linked to phenytoin usage. Whilst emphasizes the importance of monitoring patients on long-term phenytoin therapy, and it further suggests considering employing bedside imaging tools such as Ultrasound fusion imaging for follow-up of patients at risk of this type of disorder. We present a case study involving a 23-year-old woman who experienced significant neurological impairment resulting in severe cerebellar atrophy while undergoing phenytoin treatment. On cessation of phenytoin, the patient exhibited improvement with enhanced cerebellar function.http://www.sciencedirect.com/science/article/pii/S1930043323008099AnticonvulsantAtaxiaApoptosisDrug-Related side effects and adverse reactionsNystagmusPathologic |
spellingShingle | Edwin Mogere Davis Cheruiyot Manakhe Nassiuma Phenytoin-induced cerebellar atrophy: A case for reversibility of neurological decline Radiology Case Reports Anticonvulsant Ataxia Apoptosis Drug-Related side effects and adverse reactions Nystagmus Pathologic |
title | Phenytoin-induced cerebellar atrophy: A case for reversibility of neurological decline |
title_full | Phenytoin-induced cerebellar atrophy: A case for reversibility of neurological decline |
title_fullStr | Phenytoin-induced cerebellar atrophy: A case for reversibility of neurological decline |
title_full_unstemmed | Phenytoin-induced cerebellar atrophy: A case for reversibility of neurological decline |
title_short | Phenytoin-induced cerebellar atrophy: A case for reversibility of neurological decline |
title_sort | phenytoin induced cerebellar atrophy a case for reversibility of neurological decline |
topic | Anticonvulsant Ataxia Apoptosis Drug-Related side effects and adverse reactions Nystagmus Pathologic |
url | http://www.sciencedirect.com/science/article/pii/S1930043323008099 |
work_keys_str_mv | AT edwinmogere phenytoininducedcerebellaratrophyacaseforreversibilityofneurologicaldecline AT davischeruiyot phenytoininducedcerebellaratrophyacaseforreversibilityofneurologicaldecline AT manakhenassiuma phenytoininducedcerebellaratrophyacaseforreversibilityofneurologicaldecline |