Mechanism-based target therapy in primary biliary cholangitis: opportunities before liver cirrhosis?

Mechanism-based target therapy in primary biliary cholangitis: opportunities before liver cirrhosis?

Primary biliary cholangitis (PBC) is an immune-mediated liver disease characterized by cholestasis, biliary injuries, liver fibrosis, and chronic non-suppurative cholangitis. The pathogenesis of PBC is multifactorial and involves immune dysregulation, abnormal bile metabolism, and progressive fibros...

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Bibliographic Details
Main Authors: Yushu Yang, XiaoSong He, Manuel Rojas, Patrick S. C. Leung, Lixia Gao
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Immunology
Subjects:
primary biliary cholangitis
immune cells
bile acids
nuclear receptors
liver fibrosis
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1184252/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2023.1184252/full

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