Acute hepatic failure and multi-system organ failure secondary to replacement of the liver with metastatic melanoma
<p>Abstract</p> <p>Background</p> <p>Metastatic malignant melanoma to the liver resulting in fulminant hepatic failure is a rare occurrence.</p> <p>Case presentation</p> <p>A 46 year old man presented to hospital with massive hepatomegaly, elevat...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2005-06-01
|
| Series: | BMC Cancer |
| Online Access: | http://www.biomedcentral.com/1471-2407/5/67 |
| _version_ | 1818938722693939200 |
|---|---|
| author | Culleton Bruce Medlicott Shaun Kaplan Gilaad G Laupland Kevin B |
| author_facet | Culleton Bruce Medlicott Shaun Kaplan Gilaad G Laupland Kevin B |
| author_sort | Culleton Bruce |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Metastatic malignant melanoma to the liver resulting in fulminant hepatic failure is a rare occurrence.</p> <p>Case presentation</p> <p>A 46 year old man presented to hospital with massive hepatomegaly, elevated liver enzymes and increased lactate three weeks following resection of a malignant melanoma from his shoulder (Clark level 5). Initially stable, he decompensated 24 to 48 hours subsequent to presentation with respiratory failure requiring mechanical ventilation, distributive shock requiring high dose vasopressor infusion, coagulopathy refractory to plasma infusion, progressive rise in liver enzymes and severe metabolic abnormalities including hyperkalemia, acidosis, hyperphosphatemia, hyperuricemia and hypocalcemia. Refractory to aggressive physiologic support he received palliation. Autopsy revealed >80% liver infiltration by metastatic malignant melanoma.</p> <p>Conclusion</p> <p>We report a case of fulminant hepatic failure secondary to metastatic malignant melanoma infiltration of the liver.</p> |
| first_indexed | 2024-12-20T06:12:22Z |
| format | Article |
| id | doaj.art-6197a6345aa945d7a34d13fa2849e684 |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-12-20T06:12:22Z |
| publishDate | 2005-06-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj.art-6197a6345aa945d7a34d13fa2849e6842022-12-21T19:50:38ZengBMCBMC Cancer1471-24072005-06-01516710.1186/1471-2407-5-67Acute hepatic failure and multi-system organ failure secondary to replacement of the liver with metastatic melanomaCulleton BruceMedlicott ShaunKaplan Gilaad GLaupland Kevin B<p>Abstract</p> <p>Background</p> <p>Metastatic malignant melanoma to the liver resulting in fulminant hepatic failure is a rare occurrence.</p> <p>Case presentation</p> <p>A 46 year old man presented to hospital with massive hepatomegaly, elevated liver enzymes and increased lactate three weeks following resection of a malignant melanoma from his shoulder (Clark level 5). Initially stable, he decompensated 24 to 48 hours subsequent to presentation with respiratory failure requiring mechanical ventilation, distributive shock requiring high dose vasopressor infusion, coagulopathy refractory to plasma infusion, progressive rise in liver enzymes and severe metabolic abnormalities including hyperkalemia, acidosis, hyperphosphatemia, hyperuricemia and hypocalcemia. Refractory to aggressive physiologic support he received palliation. Autopsy revealed >80% liver infiltration by metastatic malignant melanoma.</p> <p>Conclusion</p> <p>We report a case of fulminant hepatic failure secondary to metastatic malignant melanoma infiltration of the liver.</p>http://www.biomedcentral.com/1471-2407/5/67 |
| spellingShingle | Culleton Bruce Medlicott Shaun Kaplan Gilaad G Laupland Kevin B Acute hepatic failure and multi-system organ failure secondary to replacement of the liver with metastatic melanoma BMC Cancer |
| title | Acute hepatic failure and multi-system organ failure secondary to replacement of the liver with metastatic melanoma |
| title_full | Acute hepatic failure and multi-system organ failure secondary to replacement of the liver with metastatic melanoma |
| title_fullStr | Acute hepatic failure and multi-system organ failure secondary to replacement of the liver with metastatic melanoma |
| title_full_unstemmed | Acute hepatic failure and multi-system organ failure secondary to replacement of the liver with metastatic melanoma |
| title_short | Acute hepatic failure and multi-system organ failure secondary to replacement of the liver with metastatic melanoma |
| title_sort | acute hepatic failure and multi system organ failure secondary to replacement of the liver with metastatic melanoma |
| url | http://www.biomedcentral.com/1471-2407/5/67 |
| work_keys_str_mv | AT culletonbruce acutehepaticfailureandmultisystemorganfailuresecondarytoreplacementoftheliverwithmetastaticmelanoma AT medlicottshaun acutehepaticfailureandmultisystemorganfailuresecondarytoreplacementoftheliverwithmetastaticmelanoma AT kaplangilaadg acutehepaticfailureandmultisystemorganfailuresecondarytoreplacementoftheliverwithmetastaticmelanoma AT lauplandkevinb acutehepaticfailureandmultisystemorganfailuresecondarytoreplacementoftheliverwithmetastaticmelanoma |