A Clinician’s Guide to the Pathophysiology of Traumatic Brain Injury
Traumatic brain injury induces a complex pathophysiological cascade of cellular events. Central components of this response include increases in cerebral glucose uptake, reductions in cerebral blood flow, indiscriminate excitatory neurotransmitter release, ionic disequilibrium, and intracellular cal...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Thieme Medical and Scientific Publishers Pvt. Ltd.
2006-06-01
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| Series: | The Indian Journal of Neurotrauma |
| Subjects: | |
| Online Access: | http://www.ijntonline.com/June06/abstracts/03.PDF |
| _version_ | 1797430464731938816 |
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| author | Andranik Madikians Christopher C Giza |
| author_facet | Andranik Madikians Christopher C Giza |
| author_sort | Andranik Madikians |
| collection | DOAJ |
| description | Traumatic brain injury induces a complex pathophysiological cascade of cellular events. Central components of this response include increases in cerebral glucose uptake, reductions in cerebral blood flow, indiscriminate excitatory neurotransmitter release, ionic disequilibrium, and intracellular calcium accumulation. Acute glutamate release and nonspecific neuronal depolarization induce threatening perturbations in neuronal function. Restoration of homeostasis requires significant increases in glucose metabolism; however, there is often a concomitant reduction in cerebral blood flow, resulting in an uncoupling of supply and demand. Understanding the nature and timing of these processes provides the practicing clinician with a mechanistic rationale for acute physiological monitoring, aggressive interventions to address and minimize secondary injuries, implementation of advanced neuroimaging techniques, and careful monitoring return to normal activity in head injured patients. |
| first_indexed | 2024-03-09T09:27:58Z |
| format | Article |
| id | doaj.art-619adb0ea4d747619b288ac6c8d033ce |
| institution | Directory Open Access Journal |
| issn | 0973-0508 |
| language | English |
| last_indexed | 2024-03-09T09:27:58Z |
| publishDate | 2006-06-01 |
| publisher | Thieme Medical and Scientific Publishers Pvt. Ltd. |
| record_format | Article |
| series | The Indian Journal of Neurotrauma |
| spelling | doaj.art-619adb0ea4d747619b288ac6c8d033ce2023-12-02T05:20:06ZengThieme Medical and Scientific Publishers Pvt. Ltd.The Indian Journal of Neurotrauma0973-05082006-06-0131917A Clinician’s Guide to the Pathophysiology of Traumatic Brain InjuryAndranik MadikiansChristopher C GizaTraumatic brain injury induces a complex pathophysiological cascade of cellular events. Central components of this response include increases in cerebral glucose uptake, reductions in cerebral blood flow, indiscriminate excitatory neurotransmitter release, ionic disequilibrium, and intracellular calcium accumulation. Acute glutamate release and nonspecific neuronal depolarization induce threatening perturbations in neuronal function. Restoration of homeostasis requires significant increases in glucose metabolism; however, there is often a concomitant reduction in cerebral blood flow, resulting in an uncoupling of supply and demand. Understanding the nature and timing of these processes provides the practicing clinician with a mechanistic rationale for acute physiological monitoring, aggressive interventions to address and minimize secondary injuries, implementation of advanced neuroimaging techniques, and careful monitoring return to normal activity in head injured patients.http://www.ijntonline.com/June06/abstracts/03.PDFcerebral blood flowglucose metabolismglutamatemonitoringpositron emission tomography (PET) |
| spellingShingle | Andranik Madikians Christopher C Giza A Clinician’s Guide to the Pathophysiology of Traumatic Brain Injury The Indian Journal of Neurotrauma cerebral blood flow glucose metabolism glutamate monitoring positron emission tomography (PET) |
| title | A Clinician’s Guide to the Pathophysiology of Traumatic Brain Injury |
| title_full | A Clinician’s Guide to the Pathophysiology of Traumatic Brain Injury |
| title_fullStr | A Clinician’s Guide to the Pathophysiology of Traumatic Brain Injury |
| title_full_unstemmed | A Clinician’s Guide to the Pathophysiology of Traumatic Brain Injury |
| title_short | A Clinician’s Guide to the Pathophysiology of Traumatic Brain Injury |
| title_sort | clinician s guide to the pathophysiology of traumatic brain injury |
| topic | cerebral blood flow glucose metabolism glutamate monitoring positron emission tomography (PET) |
| url | http://www.ijntonline.com/June06/abstracts/03.PDF |
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