Repurposing approved therapeutics for new indication: Addressing unmet needs in psoriasis treatment
Psoriasis is a chronic inflammatory autoimmune condition manifested by the hyperproliferation of keratinocytes with buildup of inflammatory red patches and scales on skin surfaces. The available treatment options for the management of psoriasis have various drawbacks, and the clinical need for effec...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-01-01
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| Series: | Current Research in Pharmacology and Drug Discovery |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590257121000286 |
| _version_ | 1819174249400631296 |
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| author | Harsha Jain Aditi Rajan Bhat Harshita Dalvi Chandraiah Godugu Shashi Bala Singh Saurabh Srivastava |
| author_facet | Harsha Jain Aditi Rajan Bhat Harshita Dalvi Chandraiah Godugu Shashi Bala Singh Saurabh Srivastava |
| author_sort | Harsha Jain |
| collection | DOAJ |
| description | Psoriasis is a chronic inflammatory autoimmune condition manifested by the hyperproliferation of keratinocytes with buildup of inflammatory red patches and scales on skin surfaces. The available treatment options for the management of psoriasis have various drawbacks, and the clinical need for effective therapeutics for this disease remain unmet; therefore, the approaches of drug repurposing or drug repositioning could potentially be used for treating indications of psoriasis. The undiscovered potential of drug repurposing or repositioning compensates for the limitations and hurdles in drug discovery and drug development processes. Drugs initially approved for other indications, including anticancer, antidiabetic, antihypertensive, and anti-arthritic activities, are being investigated for their potential in psoriasis management as a new therapeutic indication by using repurposing strategies. This article envisages the potential of various therapeutics for the management of psoriasis. |
| first_indexed | 2024-12-22T20:35:58Z |
| format | Article |
| id | doaj.art-619b83873f2a47e38ba9a048eb3e7bca |
| institution | Directory Open Access Journal |
| issn | 2590-2571 |
| language | English |
| last_indexed | 2024-12-22T20:35:58Z |
| publishDate | 2021-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Current Research in Pharmacology and Drug Discovery |
| spelling | doaj.art-619b83873f2a47e38ba9a048eb3e7bca2022-12-21T18:13:28ZengElsevierCurrent Research in Pharmacology and Drug Discovery2590-25712021-01-012100041Repurposing approved therapeutics for new indication: Addressing unmet needs in psoriasis treatmentHarsha Jain0Aditi Rajan Bhat1Harshita Dalvi2Chandraiah Godugu3Shashi Bala Singh4Saurabh Srivastava5Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad, Telangana, 500037, IndiaDepartment of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad, Telangana, 500037, IndiaDepartment of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad, Telangana, 500037, IndiaDepartment of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad, Telangana, 500037, IndiaDepartment of Biological Sciences, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad, Telangana, 500037, IndiaDepartment of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad, Telangana, 500037, India; Corresponding author. Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), Balanagar, Hyderabad, 500037, Telangana, India.Psoriasis is a chronic inflammatory autoimmune condition manifested by the hyperproliferation of keratinocytes with buildup of inflammatory red patches and scales on skin surfaces. The available treatment options for the management of psoriasis have various drawbacks, and the clinical need for effective therapeutics for this disease remain unmet; therefore, the approaches of drug repurposing or drug repositioning could potentially be used for treating indications of psoriasis. The undiscovered potential of drug repurposing or repositioning compensates for the limitations and hurdles in drug discovery and drug development processes. Drugs initially approved for other indications, including anticancer, antidiabetic, antihypertensive, and anti-arthritic activities, are being investigated for their potential in psoriasis management as a new therapeutic indication by using repurposing strategies. This article envisages the potential of various therapeutics for the management of psoriasis.http://www.sciencedirect.com/science/article/pii/S2590257121000286Drug repurposingPsoriasisInflammationClinical developmentRegulatory consideration |
| spellingShingle | Harsha Jain Aditi Rajan Bhat Harshita Dalvi Chandraiah Godugu Shashi Bala Singh Saurabh Srivastava Repurposing approved therapeutics for new indication: Addressing unmet needs in psoriasis treatment Current Research in Pharmacology and Drug Discovery Drug repurposing Psoriasis Inflammation Clinical development Regulatory consideration |
| title | Repurposing approved therapeutics for new indication: Addressing unmet needs in psoriasis treatment |
| title_full | Repurposing approved therapeutics for new indication: Addressing unmet needs in psoriasis treatment |
| title_fullStr | Repurposing approved therapeutics for new indication: Addressing unmet needs in psoriasis treatment |
| title_full_unstemmed | Repurposing approved therapeutics for new indication: Addressing unmet needs in psoriasis treatment |
| title_short | Repurposing approved therapeutics for new indication: Addressing unmet needs in psoriasis treatment |
| title_sort | repurposing approved therapeutics for new indication addressing unmet needs in psoriasis treatment |
| topic | Drug repurposing Psoriasis Inflammation Clinical development Regulatory consideration |
| url | http://www.sciencedirect.com/science/article/pii/S2590257121000286 |
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