A New Live Auxotrophic Vaccine Induces Cross-Protection against <i>Klebsiella pneumoniae</i> Infections in Mice

A New Live Auxotrophic Vaccine Induces Cross-Protection against <i>Klebsiella pneumoniae</i> Infections in Mice

The development of a whole-cell vaccine from bacteria auxotrophic for D-amino acids present in the bacterial cell wall is considered a promising strategy for providing protection against bacterial infections. Here, we constructed a prototype vaccine, consisting of a glutamate racemase-deficient muta...

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Bibliographic Details
Main Authors: Miriam Moscoso, Juan A. Vallejo, Maria P. Cabral, Patricia García, Víctor Fuentes-Valverde, Eva Gato, Jorge Arca-Suárez, Pablo Aja-Macaya, Germán Bou
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Vaccines
Subjects:
<i>Klebsiella pneumoniae</i>
live vaccines
D-glutamate auxotrophy
glutamate racemase
cross-protection
Online Access:https://www.mdpi.com/2076-393X/10/6/953

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