Differential regulation of neuronal excitability by nicotine and substance P in subdivisions of the medial habenula
The medial habenula (MHb) plays an important role in nicotine-related behaviors, such as aversion and withdrawal. The MHb is composed of distinct subregions with unique neurotransmitter expression and neuronal connectivity. Here, we showed that nicotine and substance P (SP) differentially regulate n...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2018-05-01
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| Series: | Animal Cells and Systems |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/19768354.2018.1456485 |
| _version_ | 1818359413481668608 |
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| author | Changwoo Lee Soonje Lee Changsu Woo Shin Jung Kang Yunhee Kim Kwon Ki Soon Shin |
| author_facet | Changwoo Lee Soonje Lee Changsu Woo Shin Jung Kang Yunhee Kim Kwon Ki Soon Shin |
| author_sort | Changwoo Lee |
| collection | DOAJ |
| description | The medial habenula (MHb) plays an important role in nicotine-related behaviors, such as aversion and withdrawal. The MHb is composed of distinct subregions with unique neurotransmitter expression and neuronal connectivity. Here, we showed that nicotine and substance P (SP) differentially regulate neuronal excitability in subdivisions of the MHb (ventrolateral division, MHbVL; dorsal division; MHbD and superior division: MHbS). Nicotine remarkably increased spontaneous neuronal firing in the MHbVL and MHbD, but not in the MHbS, which was consistent with different magnitudes of whole-cell inward currents evoked by nicotine in each subdivision. Meanwhile, SP enhanced neuronal excitability in the MHbVL and MHbS. Although the MHbD is composed of SP-expressing neurons, they did not respond to SP. Neurons in the MHbVL increased their firing in response to bath-applied nicotine, which was attenuated by neurokinin receptor antagonists. Furthermore, nicotine addiction and withdrawal attenuated and augmented excitatory SP effects in the MHbVL, respectively. On the whole, we suggest that MHb-involving nicotine-related behaviors might be associated with SP signaling in MHb subdivisions. |
| first_indexed | 2024-12-13T20:44:30Z |
| format | Article |
| id | doaj.art-619cb238f2ac4a98a52a97a825b4dca8 |
| institution | Directory Open Access Journal |
| issn | 1976-8354 2151-2485 |
| language | English |
| last_indexed | 2024-12-13T20:44:30Z |
| publishDate | 2018-05-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Animal Cells and Systems |
| spelling | doaj.art-619cb238f2ac4a98a52a97a825b4dca82022-12-21T23:32:03ZengTaylor & Francis GroupAnimal Cells and Systems1976-83542151-24852018-05-0122316517110.1080/19768354.2018.14564851456485Differential regulation of neuronal excitability by nicotine and substance P in subdivisions of the medial habenulaChangwoo Lee0Soonje Lee1Changsu Woo2Shin Jung Kang3Yunhee Kim Kwon4Ki Soon Shin5Kyung Hee UniversityKyung Hee UniversityKyung Hee UniversitySejong UniversityKyung Hee UniversityKyung Hee UniversityThe medial habenula (MHb) plays an important role in nicotine-related behaviors, such as aversion and withdrawal. The MHb is composed of distinct subregions with unique neurotransmitter expression and neuronal connectivity. Here, we showed that nicotine and substance P (SP) differentially regulate neuronal excitability in subdivisions of the MHb (ventrolateral division, MHbVL; dorsal division; MHbD and superior division: MHbS). Nicotine remarkably increased spontaneous neuronal firing in the MHbVL and MHbD, but not in the MHbS, which was consistent with different magnitudes of whole-cell inward currents evoked by nicotine in each subdivision. Meanwhile, SP enhanced neuronal excitability in the MHbVL and MHbS. Although the MHbD is composed of SP-expressing neurons, they did not respond to SP. Neurons in the MHbVL increased their firing in response to bath-applied nicotine, which was attenuated by neurokinin receptor antagonists. Furthermore, nicotine addiction and withdrawal attenuated and augmented excitatory SP effects in the MHbVL, respectively. On the whole, we suggest that MHb-involving nicotine-related behaviors might be associated with SP signaling in MHb subdivisions.http://dx.doi.org/10.1080/19768354.2018.1456485Medial habenulanicotinesubstance Paddictionwithdrawal |
| spellingShingle | Changwoo Lee Soonje Lee Changsu Woo Shin Jung Kang Yunhee Kim Kwon Ki Soon Shin Differential regulation of neuronal excitability by nicotine and substance P in subdivisions of the medial habenula Animal Cells and Systems Medial habenula nicotine substance P addiction withdrawal |
| title | Differential regulation of neuronal excitability by nicotine and substance P in subdivisions of the medial habenula |
| title_full | Differential regulation of neuronal excitability by nicotine and substance P in subdivisions of the medial habenula |
| title_fullStr | Differential regulation of neuronal excitability by nicotine and substance P in subdivisions of the medial habenula |
| title_full_unstemmed | Differential regulation of neuronal excitability by nicotine and substance P in subdivisions of the medial habenula |
| title_short | Differential regulation of neuronal excitability by nicotine and substance P in subdivisions of the medial habenula |
| title_sort | differential regulation of neuronal excitability by nicotine and substance p in subdivisions of the medial habenula |
| topic | Medial habenula nicotine substance P addiction withdrawal |
| url | http://dx.doi.org/10.1080/19768354.2018.1456485 |
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