Ion channels in cancer-induced bone pain: from molecular mechanisms to clinical applications
Cancer-induced bone pain (CIBP) caused by bone metastasis is one of the most prevalent diseases, and current treatments rely primarily on opioids, which have significant side effects. However, recent developments in pharmaceutical science have identified several new mechanisms for CIBP, including th...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-08-01
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| Series: | Frontiers in Molecular Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnmol.2023.1239599/full |
| _version_ | 1797741615633137664 |
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| author | Huan-Jun Lu Xiao-Bo Wu Qian-Qi Wei |
| author_facet | Huan-Jun Lu Xiao-Bo Wu Qian-Qi Wei |
| author_sort | Huan-Jun Lu |
| collection | DOAJ |
| description | Cancer-induced bone pain (CIBP) caused by bone metastasis is one of the most prevalent diseases, and current treatments rely primarily on opioids, which have significant side effects. However, recent developments in pharmaceutical science have identified several new mechanisms for CIBP, including the targeted modification of certain ion channels and receptors. Ion channels are transmembrane proteins, which are situated on biological cell membranes, which facilitate passive transport of inorganic ions across membranes. They are involved in various physiological processes, including transmission of pain signals in the nervous system. In recent years, there has been an increasing interest in the role of ion channels in chronic pain, including CIBP. Therefore, in this review, we summarize the current literature on ion channels, related receptors, and drugs and explore the mechanism of CIBP. Targeting ion channels and regulating their activity might be key to treating pain associated with bone cancer and offer new treatment avenues. |
| first_indexed | 2024-03-12T14:29:16Z |
| format | Article |
| id | doaj.art-619cbdabaef04f68a82a2aecd5f172fe |
| institution | Directory Open Access Journal |
| issn | 1662-5099 |
| language | English |
| last_indexed | 2024-03-12T14:29:16Z |
| publishDate | 2023-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Neuroscience |
| spelling | doaj.art-619cbdabaef04f68a82a2aecd5f172fe2023-08-17T17:02:44ZengFrontiers Media S.A.Frontiers in Molecular Neuroscience1662-50992023-08-011610.3389/fnmol.2023.12395991239599Ion channels in cancer-induced bone pain: from molecular mechanisms to clinical applicationsHuan-Jun Lu0Xiao-Bo Wu1Qian-Qi Wei2Institute of Pain Medicine and Special Environmental Medicine, Nantong University, Nantong, ChinaInstitute of Pain Medicine and Special Environmental Medicine, Nantong University, Nantong, ChinaDepartment of Infectious Diseases, General Hospital of Tibet Military Command, Xizang, ChinaCancer-induced bone pain (CIBP) caused by bone metastasis is one of the most prevalent diseases, and current treatments rely primarily on opioids, which have significant side effects. However, recent developments in pharmaceutical science have identified several new mechanisms for CIBP, including the targeted modification of certain ion channels and receptors. Ion channels are transmembrane proteins, which are situated on biological cell membranes, which facilitate passive transport of inorganic ions across membranes. They are involved in various physiological processes, including transmission of pain signals in the nervous system. In recent years, there has been an increasing interest in the role of ion channels in chronic pain, including CIBP. Therefore, in this review, we summarize the current literature on ion channels, related receptors, and drugs and explore the mechanism of CIBP. Targeting ion channels and regulating their activity might be key to treating pain associated with bone cancer and offer new treatment avenues.https://www.frontiersin.org/articles/10.3389/fnmol.2023.1239599/fullchronic paincancer-induced bone painion channelsantinociceptionclinical application |
| spellingShingle | Huan-Jun Lu Xiao-Bo Wu Qian-Qi Wei Ion channels in cancer-induced bone pain: from molecular mechanisms to clinical applications Frontiers in Molecular Neuroscience chronic pain cancer-induced bone pain ion channels antinociception clinical application |
| title | Ion channels in cancer-induced bone pain: from molecular mechanisms to clinical applications |
| title_full | Ion channels in cancer-induced bone pain: from molecular mechanisms to clinical applications |
| title_fullStr | Ion channels in cancer-induced bone pain: from molecular mechanisms to clinical applications |
| title_full_unstemmed | Ion channels in cancer-induced bone pain: from molecular mechanisms to clinical applications |
| title_short | Ion channels in cancer-induced bone pain: from molecular mechanisms to clinical applications |
| title_sort | ion channels in cancer induced bone pain from molecular mechanisms to clinical applications |
| topic | chronic pain cancer-induced bone pain ion channels antinociception clinical application |
| url | https://www.frontiersin.org/articles/10.3389/fnmol.2023.1239599/full |
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