Pharmacological enhancement of exposure-based treatment in PTSD: a qualitative review
There is a good amount of evidence that exposure therapy is an effective treatment for posttraumatic stress disorder (PTSD). Notwithstanding its efficacy, there is room for improvement, since a large proportion of patients does not benefit from treatment. Recently, an interesting new direction in th...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2013-10-01
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| Series: | European Journal of Psychotraumatology |
| Subjects: | |
| Online Access: | http://www.ejpt.net/index.php/ejpt/article/download/21626/pdf_1 |
| _version_ | 1818527838394908672 |
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| author | Rianne A. de Kleine Barbara O. Rothbaum Agnes van Minnen |
| author_facet | Rianne A. de Kleine Barbara O. Rothbaum Agnes van Minnen |
| author_sort | Rianne A. de Kleine |
| collection | DOAJ |
| description | There is a good amount of evidence that exposure therapy is an effective treatment for posttraumatic stress disorder (PTSD). Notwithstanding its efficacy, there is room for improvement, since a large proportion of patients does not benefit from treatment. Recently, an interesting new direction in the improvement of exposure therapy efficacy for PTSD emerged. Basic research found evidence of the pharmacological enhancement of the underlying learning and memory processes of exposure therapy. The current review aims to give an overview of clinical studies on pharmacological enhancement of exposure-based treatment for PTSD. The working mechanisms, efficacy studies in PTSD patients, and clinical utility of four different pharmacological enhancers will be discussed: D-cycloserine, MDMA, hydrocortisone, and propranolol. |
| first_indexed | 2024-12-11T06:41:34Z |
| format | Article |
| id | doaj.art-619e2f739e234b3ba29d50c3fc8e60ab |
| institution | Directory Open Access Journal |
| issn | 2000-8066 |
| language | English |
| last_indexed | 2024-12-11T06:41:34Z |
| publishDate | 2013-10-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | European Journal of Psychotraumatology |
| spelling | doaj.art-619e2f739e234b3ba29d50c3fc8e60ab2022-12-22T01:17:13ZengTaylor & Francis GroupEuropean Journal of Psychotraumatology2000-80662013-10-014011510.3402/ejpt.v4i0.21626Pharmacological enhancement of exposure-based treatment in PTSD: a qualitative reviewRianne A. de KleineBarbara O. RothbaumAgnes van MinnenThere is a good amount of evidence that exposure therapy is an effective treatment for posttraumatic stress disorder (PTSD). Notwithstanding its efficacy, there is room for improvement, since a large proportion of patients does not benefit from treatment. Recently, an interesting new direction in the improvement of exposure therapy efficacy for PTSD emerged. Basic research found evidence of the pharmacological enhancement of the underlying learning and memory processes of exposure therapy. The current review aims to give an overview of clinical studies on pharmacological enhancement of exposure-based treatment for PTSD. The working mechanisms, efficacy studies in PTSD patients, and clinical utility of four different pharmacological enhancers will be discussed: D-cycloserine, MDMA, hydrocortisone, and propranolol.www.ejpt.net/index.php/ejpt/article/download/21626/pdf_1Posttraumatic stress disordercognitive enhancerstreatment efficacyexposure therapy |
| spellingShingle | Rianne A. de Kleine Barbara O. Rothbaum Agnes van Minnen Pharmacological enhancement of exposure-based treatment in PTSD: a qualitative review European Journal of Psychotraumatology Posttraumatic stress disorder cognitive enhancers treatment efficacy exposure therapy |
| title | Pharmacological enhancement of exposure-based treatment in PTSD: a qualitative review |
| title_full | Pharmacological enhancement of exposure-based treatment in PTSD: a qualitative review |
| title_fullStr | Pharmacological enhancement of exposure-based treatment in PTSD: a qualitative review |
| title_full_unstemmed | Pharmacological enhancement of exposure-based treatment in PTSD: a qualitative review |
| title_short | Pharmacological enhancement of exposure-based treatment in PTSD: a qualitative review |
| title_sort | pharmacological enhancement of exposure based treatment in ptsd a qualitative review |
| topic | Posttraumatic stress disorder cognitive enhancers treatment efficacy exposure therapy |
| url | http://www.ejpt.net/index.php/ejpt/article/download/21626/pdf_1 |
| work_keys_str_mv | AT rianneadekleine pharmacologicalenhancementofexposurebasedtreatmentinptsdaqualitativereview AT barbaraorothbaum pharmacologicalenhancementofexposurebasedtreatmentinptsdaqualitativereview AT agnesvanminnen pharmacologicalenhancementofexposurebasedtreatmentinptsdaqualitativereview |