A study on the anti-skin tumor and anti-UVB damage effects of Gastrodia elata Bl. Products transformed by Armillaria mellea
Skin cancer is a malignant tumour that can spread in the skin and is a serious threat to human health. Excessive ultraviolet radiation is one of the most common factors that leads to skin cancer. The purpose of this study was to evaluate the anti-skin tumour and anti-UVB damage effects of Armillaria...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2022-12-01
|
| Series: | Food and Agricultural Immunology |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/09540105.2022.2120853 |
| _version_ | 1811266760146419712 |
|---|---|
| author | Tong Zheng Yugang Gao Zhilong Zhang XinYue Li Pu Zang Yan Zhao Zhongmei He |
| author_facet | Tong Zheng Yugang Gao Zhilong Zhang XinYue Li Pu Zang Yan Zhao Zhongmei He |
| author_sort | Tong Zheng |
| collection | DOAJ |
| description | Skin cancer is a malignant tumour that can spread in the skin and is a serious threat to human health. Excessive ultraviolet radiation is one of the most common factors that leads to skin cancer. The purpose of this study was to evaluate the anti-skin tumour and anti-UVB damage effects of Armillaria mellea (Vahl) P. Kumm transformed Gastrodia elata Bl products (ATGP). Gastrodia elata Blume f.glauca S. Chows from Changbai Mountain and 4 Armillaria mellea (Vahl) P. Kumm strains were used as experimental materials. First, the optimum fungal strains of Armillaria mellea used to transform gastrodin were screened. Then, the MTT assay and scratch test proved that ATGP had anti-B16 melanoma cell activity in vitro. Furthermore, the anti-UVB damage effect of ATGP was proven by a UVB damage mouse skin model and HaCat photoaging model, and its mechanism was preliminarily discussed. |
| first_indexed | 2024-04-12T20:49:07Z |
| format | Article |
| id | doaj.art-619f0a216ba64d8a9a4bf80ce30ab8e3 |
| institution | Directory Open Access Journal |
| issn | 0954-0105 1465-3443 |
| language | English |
| last_indexed | 2024-04-12T20:49:07Z |
| publishDate | 2022-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Food and Agricultural Immunology |
| spelling | doaj.art-619f0a216ba64d8a9a4bf80ce30ab8e32022-12-22T03:17:11ZengTaylor & Francis GroupFood and Agricultural Immunology0954-01051465-34432022-12-0133173675110.1080/09540105.2022.2120853A study on the anti-skin tumor and anti-UVB damage effects of Gastrodia elata Bl. Products transformed by Armillaria melleaTong Zheng0Yugang Gao1Zhilong Zhang2XinYue Li3Pu Zang4Yan Zhao5Zhongmei He6College of Traditional Chinese Medicine, Jilin Agricultural University, Chang Chun, People’s Republic of ChinaCollege of Traditional Chinese Medicine, Jilin Agricultural University, Chang Chun, People’s Republic of ChinaCollege of Traditional Chinese Medicine, Jilin Agricultural University, Chang Chun, People’s Republic of ChinaCollege of Traditional Chinese Medicine, Jilin Agricultural University, Chang Chun, People’s Republic of ChinaCollege of Traditional Chinese Medicine, Jilin Agricultural University, Chang Chun, People’s Republic of ChinaCollege of Traditional Chinese Medicine, Jilin Agricultural University, Chang Chun, People’s Republic of ChinaCollege of Traditional Chinese Medicine, Jilin Agricultural University, Chang Chun, People’s Republic of ChinaSkin cancer is a malignant tumour that can spread in the skin and is a serious threat to human health. Excessive ultraviolet radiation is one of the most common factors that leads to skin cancer. The purpose of this study was to evaluate the anti-skin tumour and anti-UVB damage effects of Armillaria mellea (Vahl) P. Kumm transformed Gastrodia elata Bl products (ATGP). Gastrodia elata Blume f.glauca S. Chows from Changbai Mountain and 4 Armillaria mellea (Vahl) P. Kumm strains were used as experimental materials. First, the optimum fungal strains of Armillaria mellea used to transform gastrodin were screened. Then, the MTT assay and scratch test proved that ATGP had anti-B16 melanoma cell activity in vitro. Furthermore, the anti-UVB damage effect of ATGP was proven by a UVB damage mouse skin model and HaCat photoaging model, and its mechanism was preliminarily discussed.https://www.tandfonline.com/doi/10.1080/09540105.2022.2120853Gastrodia elataArmillaria melleamicrobial transformationanti-skin tumouranti-ultraviolet |
| spellingShingle | Tong Zheng Yugang Gao Zhilong Zhang XinYue Li Pu Zang Yan Zhao Zhongmei He A study on the anti-skin tumor and anti-UVB damage effects of Gastrodia elata Bl. Products transformed by Armillaria mellea Food and Agricultural Immunology Gastrodia elata Armillaria mellea microbial transformation anti-skin tumour anti-ultraviolet |
| title | A study on the anti-skin tumor and anti-UVB damage effects of Gastrodia elata Bl. Products transformed by Armillaria mellea |
| title_full | A study on the anti-skin tumor and anti-UVB damage effects of Gastrodia elata Bl. Products transformed by Armillaria mellea |
| title_fullStr | A study on the anti-skin tumor and anti-UVB damage effects of Gastrodia elata Bl. Products transformed by Armillaria mellea |
| title_full_unstemmed | A study on the anti-skin tumor and anti-UVB damage effects of Gastrodia elata Bl. Products transformed by Armillaria mellea |
| title_short | A study on the anti-skin tumor and anti-UVB damage effects of Gastrodia elata Bl. Products transformed by Armillaria mellea |
| title_sort | study on the anti skin tumor and anti uvb damage effects of gastrodia elata bl products transformed by armillaria mellea |
| topic | Gastrodia elata Armillaria mellea microbial transformation anti-skin tumour anti-ultraviolet |
| url | https://www.tandfonline.com/doi/10.1080/09540105.2022.2120853 |
| work_keys_str_mv | AT tongzheng astudyontheantiskintumorandantiuvbdamageeffectsofgastrodiaelatablproductstransformedbyarmillariamellea AT yuganggao astudyontheantiskintumorandantiuvbdamageeffectsofgastrodiaelatablproductstransformedbyarmillariamellea AT zhilongzhang astudyontheantiskintumorandantiuvbdamageeffectsofgastrodiaelatablproductstransformedbyarmillariamellea AT xinyueli astudyontheantiskintumorandantiuvbdamageeffectsofgastrodiaelatablproductstransformedbyarmillariamellea AT puzang astudyontheantiskintumorandantiuvbdamageeffectsofgastrodiaelatablproductstransformedbyarmillariamellea AT yanzhao astudyontheantiskintumorandantiuvbdamageeffectsofgastrodiaelatablproductstransformedbyarmillariamellea AT zhongmeihe astudyontheantiskintumorandantiuvbdamageeffectsofgastrodiaelatablproductstransformedbyarmillariamellea AT tongzheng studyontheantiskintumorandantiuvbdamageeffectsofgastrodiaelatablproductstransformedbyarmillariamellea AT yuganggao studyontheantiskintumorandantiuvbdamageeffectsofgastrodiaelatablproductstransformedbyarmillariamellea AT zhilongzhang studyontheantiskintumorandantiuvbdamageeffectsofgastrodiaelatablproductstransformedbyarmillariamellea AT xinyueli studyontheantiskintumorandantiuvbdamageeffectsofgastrodiaelatablproductstransformedbyarmillariamellea AT puzang studyontheantiskintumorandantiuvbdamageeffectsofgastrodiaelatablproductstransformedbyarmillariamellea AT yanzhao studyontheantiskintumorandantiuvbdamageeffectsofgastrodiaelatablproductstransformedbyarmillariamellea AT zhongmeihe studyontheantiskintumorandantiuvbdamageeffectsofgastrodiaelatablproductstransformedbyarmillariamellea |