Formulation and In-Vitro/Ex-Vivo Characterization of Pregelled Hybrid Alginate–Chitosan Microparticles for Ocular Delivery of Ketorolac Tromethamine

Formulation and In-Vitro/Ex-Vivo Characterization of Pregelled Hybrid Alginate–Chitosan Microparticles for Ocular Delivery of Ketorolac Tromethamine

Innovative hybrid chitosan–sodium alginate (Ch–Ag) microparticles (MPs) were fabricated using both the ionic gelation method as well as the pre-gelation technique. The hybrid Ch–Ag MPs were studied for size, zeta potential, morphology, mucoadhesion, in-vitro release, corneal permeation, and ocular i...

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Bibliographic Details
Main Authors: Zeinab Fathalla, Adel Al Fatease, Hamdy Abdelkader
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:Polymers
Subjects:
ketorolac
hybrid microparticles
permeation
chitosan
alginate
lens cell lines
Online Access:https://www.mdpi.com/2073-4360/15/13/2773

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