Prospective multi-center study of oncologic outcomes of robot-assisted partial nephrectomy for pT1 renal cell carcinoma
<p>Abstract</p> <p>Background</p> <p>Partial nephrectomy has been increasingly recommended over radical nephrectomy for the management of small renal masses based on improved renal functional outcomes without sacrifice of oncologic effectiveness. Robot-assisted partial...
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| Format: | Article |
| Language: | English |
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BMC
2012-04-01
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| Series: | BMC Urology |
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| Online Access: | http://www.biomedcentral.com/1471-2490/12/11 |
| _version_ | 1819038579537477632 |
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| author | Kyllo Rachel L Tanagho Youssef S Kaouk Jihad H Stifelman Michael D Rogers Craig G Hillyer Shahab P Sukumar Shyam S Nepple Kenneth G Bhayani Sam B |
| author_facet | Kyllo Rachel L Tanagho Youssef S Kaouk Jihad H Stifelman Michael D Rogers Craig G Hillyer Shahab P Sukumar Shyam S Nepple Kenneth G Bhayani Sam B |
| author_sort | Kyllo Rachel L |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Partial nephrectomy has been increasingly recommended over radical nephrectomy for the management of small renal masses based on improved renal functional outcomes without sacrifice of oncologic effectiveness. Robot-assisted partial nephrectomy (RAPN) has been introduced in an effort to offer another minimally invasive option for nephron-sparing surgery. However, reports of RAPN have been limited to short-term perioperative outcomes. The goal of this study is to report and evaluate the initial oncologic outcomes of RAPN. Utilizing prospectively obtained data on RAPN performed by four surgeons at four separate tertiary care centers, we selected patients with unilateral, localized, non-familial, pathologically-confirmed pT1 renal cell carcinoma and a minimum post-operative follow-up of 12 months.</p> <p>Methods</p> <p>Utilizing prospectively obtained data on RAPN performed by four surgeons at four separate tertiary care centers, we selected patients with unilateral, localized, non-familial, pathologically-confirmed pT1 renal cell carcinoma and a minimum post-operative follow-up of 12 months. Survival analysis (disease-free, cancer-specific, and overall survival) was performed, and Kaplan-Meier curves were generated. </p> <p>Results</p> <p>RAPN was performed in 124 patients with a median tumor size of 3.0 cm (IQR 2.2-4.2 cm). Median follow-up was 29 months (range 12-46 months). Positive parenchymal surgical margins occurred in two patients (1.6 %), both of whom were recurrence-free at 30 and 34 months after surgery. The three-year Kaplan-Meier estimated disease-free survival was 94.9 %, cancer-specific survival was 99.1 %, and overall survival was 97.3 %.</p> <p>Conclusions</p> <p>In our cohort of patients with small renal carcinomas who were followed for a median of 29 months, recurrence and survival outcomes were similar to those reported for open and laparoscopic partial nephrectomy. Further long-term outcomes will be needed to definitively claim that RAPN is oncologically equivalent to other surgical approaches.</p> |
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| institution | Directory Open Access Journal |
| issn | 1471-2490 |
| language | English |
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| spelling | doaj.art-61a2157333b54c698a7ac24a0a47dd922022-12-21T19:09:58ZengBMCBMC Urology1471-24902012-04-011211110.1186/1471-2490-12-11Prospective multi-center study of oncologic outcomes of robot-assisted partial nephrectomy for pT1 renal cell carcinomaKyllo Rachel LTanagho Youssef SKaouk Jihad HStifelman Michael DRogers Craig GHillyer Shahab PSukumar Shyam SNepple Kenneth GBhayani Sam B<p>Abstract</p> <p>Background</p> <p>Partial nephrectomy has been increasingly recommended over radical nephrectomy for the management of small renal masses based on improved renal functional outcomes without sacrifice of oncologic effectiveness. Robot-assisted partial nephrectomy (RAPN) has been introduced in an effort to offer another minimally invasive option for nephron-sparing surgery. However, reports of RAPN have been limited to short-term perioperative outcomes. The goal of this study is to report and evaluate the initial oncologic outcomes of RAPN. Utilizing prospectively obtained data on RAPN performed by four surgeons at four separate tertiary care centers, we selected patients with unilateral, localized, non-familial, pathologically-confirmed pT1 renal cell carcinoma and a minimum post-operative follow-up of 12 months.</p> <p>Methods</p> <p>Utilizing prospectively obtained data on RAPN performed by four surgeons at four separate tertiary care centers, we selected patients with unilateral, localized, non-familial, pathologically-confirmed pT1 renal cell carcinoma and a minimum post-operative follow-up of 12 months. Survival analysis (disease-free, cancer-specific, and overall survival) was performed, and Kaplan-Meier curves were generated. </p> <p>Results</p> <p>RAPN was performed in 124 patients with a median tumor size of 3.0 cm (IQR 2.2-4.2 cm). Median follow-up was 29 months (range 12-46 months). Positive parenchymal surgical margins occurred in two patients (1.6 %), both of whom were recurrence-free at 30 and 34 months after surgery. The three-year Kaplan-Meier estimated disease-free survival was 94.9 %, cancer-specific survival was 99.1 %, and overall survival was 97.3 %.</p> <p>Conclusions</p> <p>In our cohort of patients with small renal carcinomas who were followed for a median of 29 months, recurrence and survival outcomes were similar to those reported for open and laparoscopic partial nephrectomy. Further long-term outcomes will be needed to definitively claim that RAPN is oncologically equivalent to other surgical approaches.</p>http://www.biomedcentral.com/1471-2490/12/11Renal cell carcinomaPartial nephrectomyRobotic partial nephrectomyOncologic outcomesNephron-sparing surgery |
| spellingShingle | Kyllo Rachel L Tanagho Youssef S Kaouk Jihad H Stifelman Michael D Rogers Craig G Hillyer Shahab P Sukumar Shyam S Nepple Kenneth G Bhayani Sam B Prospective multi-center study of oncologic outcomes of robot-assisted partial nephrectomy for pT1 renal cell carcinoma BMC Urology Renal cell carcinoma Partial nephrectomy Robotic partial nephrectomy Oncologic outcomes Nephron-sparing surgery |
| title | Prospective multi-center study of oncologic outcomes of robot-assisted partial nephrectomy for pT1 renal cell carcinoma |
| title_full | Prospective multi-center study of oncologic outcomes of robot-assisted partial nephrectomy for pT1 renal cell carcinoma |
| title_fullStr | Prospective multi-center study of oncologic outcomes of robot-assisted partial nephrectomy for pT1 renal cell carcinoma |
| title_full_unstemmed | Prospective multi-center study of oncologic outcomes of robot-assisted partial nephrectomy for pT1 renal cell carcinoma |
| title_short | Prospective multi-center study of oncologic outcomes of robot-assisted partial nephrectomy for pT1 renal cell carcinoma |
| title_sort | prospective multi center study of oncologic outcomes of robot assisted partial nephrectomy for pt1 renal cell carcinoma |
| topic | Renal cell carcinoma Partial nephrectomy Robotic partial nephrectomy Oncologic outcomes Nephron-sparing surgery |
| url | http://www.biomedcentral.com/1471-2490/12/11 |
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