COPD monocytes demonstrate impaired migratory ability

COPD monocytes demonstrate impaired migratory ability

Abstract Background Increased lung macrophage numbers in COPD may arise from upregulation of blood monocyte recruitment into the lungs. CCR5 is a monocyte chemokine receptor regulated by interleukin-6 (IL-6); the concentration of CCR5 ligands are known to be elevated in COPD lungs. The objective of...

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Bibliographic Details
Main Authors: Arjun K Ravi, Jonathan Plumb, Rosemary Gaskell, Sarah Mason, Caroline S Broome, George Booth, Matthew Catley, Jørgen Vestbo, Dave Singh
Format: Article
Language:English
Published: BMC 2017-05-01
Series:Respiratory Research
Subjects:
COPD
Monocytes
CCR5
Chemotaxis
Interleukin-6
Online Access:http://link.springer.com/article/10.1186/s12931-017-0569-y

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