Evaluation of the Prophylactic Effect of Amiodarone in Reducing the Incidence of Post-CABG Atrial Fibrillation
Abstract Background: Atrial fibrillation (AF) is the most common complication after coronary artery bypass graft surgery (CABG). This complication causes an increase in morbidity and mortality after CABG and also increases the length of ICU stay and hospitalization. The aim of this study is to eval...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | fas |
| Published: |
Arak Medical University
2015-06-01
|
| Series: | Majallah-i dānishgāh-i ̒ulūm-i pizishkī-i Arāk |
| Subjects: | |
| Online Access: | http://amuj.arakmu.ac.ir/article-1-3717-en.pdf |
| _version_ | 1818211081390129152 |
|---|---|
| author | Niloofar Dadashpour Esmaeel Moshiri Ali Reza Kamali Ali Reza Rostami Majid Golestani Eraghi |
| author_facet | Niloofar Dadashpour Esmaeel Moshiri Ali Reza Kamali Ali Reza Rostami Majid Golestani Eraghi |
| author_sort | Niloofar Dadashpour |
| collection | DOAJ |
| description | Abstract
Background: Atrial fibrillation (AF) is the most common complication after coronary artery bypass graft surgery (CABG). This complication causes an increase in morbidity and mortality after CABG and also increases the length of ICU stay and hospitalization. The aim of this study is to evaluate the prophylactic effect of amiodarone in reducing the incidence of post CABG atrial fibrillation.
Materials and Methods: In this clinical trial study, 204 patients, candidate for elective CABG, entered the study according to inclusion and exclusion criteria, and randomly divided into two equal groups. The case group received 300 mg of intravenous amiodarone before anesthesia induction and the control group received normal saline. Incidence of AF was recorded until 24 hours after CABG.
Results: The incidence of post CABG AF was 16 patients in the case group and 35 patients in the control group. Comparison of the frequency of AF between groups by Chi square analyses showed a significant difference (p=0.037) and the incidence of AF was significantly lower in the amiodarone group.
Conclusion: In total, amiodarone could significantly prevent the incidence of atrial fibrillation after coronary artery bypass surgery. In this study, patients took this medication only in the first 24 hours, while in some studies, this drug has been prescribed for even 14 days. |
| first_indexed | 2024-12-12T05:26:50Z |
| format | Article |
| id | doaj.art-61a61ab2e56d4a3f8580d0a2cc051bf4 |
| institution | Directory Open Access Journal |
| issn | 1735-5338 2008-644X |
| language | fas |
| last_indexed | 2024-12-12T05:26:50Z |
| publishDate | 2015-06-01 |
| publisher | Arak Medical University |
| record_format | Article |
| series | Majallah-i dānishgāh-i ̒ulūm-i pizishkī-i Arāk |
| spelling | doaj.art-61a61ab2e56d4a3f8580d0a2cc051bf42022-12-22T00:36:27ZfasArak Medical UniversityMajallah-i dānishgāh-i ̒ulūm-i pizishkī-i Arāk1735-53382008-644X2015-06-011831927Evaluation of the Prophylactic Effect of Amiodarone in Reducing the Incidence of Post-CABG Atrial FibrillationNiloofar Dadashpour0Esmaeel Moshiri1Ali Reza Kamali2Ali Reza Rostami3Majid Golestani Eraghi4Arak University of Medical Sciences, Arak, IranDepartment of Anesthesiology, Arak University of Medical Sciences, Arak, IranDepartment of Anesthesiology, Arak University of Medical Sciences, Arak, IranDepartment of Cardiac Surgery, Arak University of Medical Sciences, Arak, IranDepartment of Internal Medicine, Arak University of Medical Sciences, Arak, IranAbstract Background: Atrial fibrillation (AF) is the most common complication after coronary artery bypass graft surgery (CABG). This complication causes an increase in morbidity and mortality after CABG and also increases the length of ICU stay and hospitalization. The aim of this study is to evaluate the prophylactic effect of amiodarone in reducing the incidence of post CABG atrial fibrillation. Materials and Methods: In this clinical trial study, 204 patients, candidate for elective CABG, entered the study according to inclusion and exclusion criteria, and randomly divided into two equal groups. The case group received 300 mg of intravenous amiodarone before anesthesia induction and the control group received normal saline. Incidence of AF was recorded until 24 hours after CABG. Results: The incidence of post CABG AF was 16 patients in the case group and 35 patients in the control group. Comparison of the frequency of AF between groups by Chi square analyses showed a significant difference (p=0.037) and the incidence of AF was significantly lower in the amiodarone group. Conclusion: In total, amiodarone could significantly prevent the incidence of atrial fibrillation after coronary artery bypass surgery. In this study, patients took this medication only in the first 24 hours, while in some studies, this drug has been prescribed for even 14 days.http://amuj.arakmu.ac.ir/article-1-3717-en.pdfAmiodaroneAtrial fibrillationCoronary artery bypass |
| spellingShingle | Niloofar Dadashpour Esmaeel Moshiri Ali Reza Kamali Ali Reza Rostami Majid Golestani Eraghi Evaluation of the Prophylactic Effect of Amiodarone in Reducing the Incidence of Post-CABG Atrial Fibrillation Majallah-i dānishgāh-i ̒ulūm-i pizishkī-i Arāk Amiodarone Atrial fibrillation Coronary artery bypass |
| title | Evaluation of the Prophylactic Effect of Amiodarone in Reducing the Incidence of Post-CABG Atrial Fibrillation |
| title_full | Evaluation of the Prophylactic Effect of Amiodarone in Reducing the Incidence of Post-CABG Atrial Fibrillation |
| title_fullStr | Evaluation of the Prophylactic Effect of Amiodarone in Reducing the Incidence of Post-CABG Atrial Fibrillation |
| title_full_unstemmed | Evaluation of the Prophylactic Effect of Amiodarone in Reducing the Incidence of Post-CABG Atrial Fibrillation |
| title_short | Evaluation of the Prophylactic Effect of Amiodarone in Reducing the Incidence of Post-CABG Atrial Fibrillation |
| title_sort | evaluation of the prophylactic effect of amiodarone in reducing the incidence of post cabg atrial fibrillation |
| topic | Amiodarone Atrial fibrillation Coronary artery bypass |
| url | http://amuj.arakmu.ac.ir/article-1-3717-en.pdf |
| work_keys_str_mv | AT niloofardadashpour evaluationoftheprophylacticeffectofamiodaroneinreducingtheincidenceofpostcabgatrialfibrillation AT esmaeelmoshiri evaluationoftheprophylacticeffectofamiodaroneinreducingtheincidenceofpostcabgatrialfibrillation AT alirezakamali evaluationoftheprophylacticeffectofamiodaroneinreducingtheincidenceofpostcabgatrialfibrillation AT alirezarostami evaluationoftheprophylacticeffectofamiodaroneinreducingtheincidenceofpostcabgatrialfibrillation AT majidgolestanieraghi evaluationoftheprophylacticeffectofamiodaroneinreducingtheincidenceofpostcabgatrialfibrillation |