Prevention and Management Strategies for Diabetic Neuropathy
Diabetic neuropathy (DN) is a common complication of diabetes that is becoming an increasing concern as the prevalence of diabetes rapidly rises. There are several types of DN, but the most prevalent and studied type is distal symmetrical polyneuropathy, which is the focus of this review and is simp...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-08-01
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| Series: | Life |
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| Online Access: | https://www.mdpi.com/2075-1729/12/8/1185 |
| _version_ | 1827599356691218432 |
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| author | Sasha Smith Pasha Normahani Tristan Lane David Hohenschurz-Schmidt Nick Oliver Alun Huw Davies |
| author_facet | Sasha Smith Pasha Normahani Tristan Lane David Hohenschurz-Schmidt Nick Oliver Alun Huw Davies |
| author_sort | Sasha Smith |
| collection | DOAJ |
| description | Diabetic neuropathy (DN) is a common complication of diabetes that is becoming an increasing concern as the prevalence of diabetes rapidly rises. There are several types of DN, but the most prevalent and studied type is distal symmetrical polyneuropathy, which is the focus of this review and is simply referred to as DN. It can lead to a wide range of sensorimotor and psychosocial symptoms and is a major risk factor for diabetic foot ulceration and Charcot neuropathic osteoarthropathy, which are associated with high rates of lower limb amputation and mortality. The prevention and management of DN are thus critical, and clinical guidelines recommend several strategies for these based on the best available evidence. This article aims to provide a narrative review of DN prevention and management strategies by discussing these guidelines and the evidence that supports them. First, the epidemiology and diverse clinical manifestations of DN are summarized. Then, prevention strategies such as glycemic control, lifestyle modifications and footcare are discussed, as well as the importance of early diagnosis. Finally, neuropathic pain management strategies and promising novel therapies under investigation such as neuromodulation devices and nutraceuticals are reviewed. |
| first_indexed | 2024-03-09T04:12:48Z |
| format | Article |
| id | doaj.art-61a67407228b40a7900ac57b9e9d8be6 |
| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-09T04:12:48Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj.art-61a67407228b40a7900ac57b9e9d8be62023-12-03T13:58:44ZengMDPI AGLife2075-17292022-08-01128118510.3390/life12081185Prevention and Management Strategies for Diabetic NeuropathySasha Smith0Pasha Normahani1Tristan Lane2David Hohenschurz-Schmidt3Nick Oliver4Alun Huw Davies5Section of Vascular Surgery, Department of Surgery and Cancer, Imperial College London, London W6 8RF, UKSection of Vascular Surgery, Department of Surgery and Cancer, Imperial College London, London W6 8RF, UKSection of Vascular Surgery, Department of Surgery and Cancer, Imperial College London, London W6 8RF, UKPain Research Group, Department of Surgery and Cancer, Imperial College London, London SW10 9NH, UKSection of Metabolic Medicine, Department of Metabolism, Digestion and Reproduction, Imperial College London, London W2 1PG, UKSection of Vascular Surgery, Department of Surgery and Cancer, Imperial College London, London W6 8RF, UKDiabetic neuropathy (DN) is a common complication of diabetes that is becoming an increasing concern as the prevalence of diabetes rapidly rises. There are several types of DN, but the most prevalent and studied type is distal symmetrical polyneuropathy, which is the focus of this review and is simply referred to as DN. It can lead to a wide range of sensorimotor and psychosocial symptoms and is a major risk factor for diabetic foot ulceration and Charcot neuropathic osteoarthropathy, which are associated with high rates of lower limb amputation and mortality. The prevention and management of DN are thus critical, and clinical guidelines recommend several strategies for these based on the best available evidence. This article aims to provide a narrative review of DN prevention and management strategies by discussing these guidelines and the evidence that supports them. First, the epidemiology and diverse clinical manifestations of DN are summarized. Then, prevention strategies such as glycemic control, lifestyle modifications and footcare are discussed, as well as the importance of early diagnosis. Finally, neuropathic pain management strategies and promising novel therapies under investigation such as neuromodulation devices and nutraceuticals are reviewed.https://www.mdpi.com/2075-1729/12/8/1185diabetesdiabetic neuropathydistal symmetrical polyneuropathyglycemic controllifestyle modificationsfootcare |
| spellingShingle | Sasha Smith Pasha Normahani Tristan Lane David Hohenschurz-Schmidt Nick Oliver Alun Huw Davies Prevention and Management Strategies for Diabetic Neuropathy Life diabetes diabetic neuropathy distal symmetrical polyneuropathy glycemic control lifestyle modifications footcare |
| title | Prevention and Management Strategies for Diabetic Neuropathy |
| title_full | Prevention and Management Strategies for Diabetic Neuropathy |
| title_fullStr | Prevention and Management Strategies for Diabetic Neuropathy |
| title_full_unstemmed | Prevention and Management Strategies for Diabetic Neuropathy |
| title_short | Prevention and Management Strategies for Diabetic Neuropathy |
| title_sort | prevention and management strategies for diabetic neuropathy |
| topic | diabetes diabetic neuropathy distal symmetrical polyneuropathy glycemic control lifestyle modifications footcare |
| url | https://www.mdpi.com/2075-1729/12/8/1185 |
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