Distinct clinicopathological features of ovarian endometriosis after long-term exposure to mifepristone
Objective Mifepristone has been used to treat endometriosis, but it can cause a constellation of endometrial alterations. Our study investigated the effects of long-term mifepristone on ovarian endometriosis. Methods We retrospectively analyzed the clinicopathological changes of ovarian endometriosi...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2022-11-01
|
| Series: | Journal of International Medical Research |
| Online Access: | https://doi.org/10.1177/03000605221134471 |
| _version_ | 1811233249934966784 |
|---|---|
| author | Yongmiao Pan Tingting Wu Haiyan Shi |
| author_facet | Yongmiao Pan Tingting Wu Haiyan Shi |
| author_sort | Yongmiao Pan |
| collection | DOAJ |
| description | Objective Mifepristone has been used to treat endometriosis, but it can cause a constellation of endometrial alterations. Our study investigated the effects of long-term mifepristone on ovarian endometriosis. Methods We retrospectively analyzed the clinicopathological changes of ovarian endometriosis in 11 Chinese patients after long-term low-dose mifepristone therapy and compared these alterations with those observed in eutopic endometrium and adenomyosis side-by-side. Immunohistochemistry was applied to investigate estrogen receptor (ER), progesterone receptor (PR), and Ki67 expression in eutopic and ectopic endometrium. Results Nearly all patients had a pelvic mass and elevated serum CA125 levels. The ovarian lesions were grossly solid, cystic-solid, or cystic. They had a grayish–reddish appearance and a fleshy, honeycomb-like cut surface. The ovarian lesions shared morphological features with the uterine endometrium, and they were characterized by dilated, crowding endometrial glands with non-physiological changes. Immunostaining revealed consistent staining for ER and PR and a low Ki67 index in both eutopic and ectopic endometrium. Conclusions Our findings suggest that ovarian endometriosis can mimic an endometrioid borderline tumor after long-term mifepristone administration. Careful histological assessment and related clinical information are critical for the correct interpretation of these rare entities. |
| first_indexed | 2024-04-12T11:17:54Z |
| format | Article |
| id | doaj.art-61a7379b94b44bc09eb3fe358dddd322 |
| institution | Directory Open Access Journal |
| issn | 1473-2300 |
| language | English |
| last_indexed | 2024-04-12T11:17:54Z |
| publishDate | 2022-11-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of International Medical Research |
| spelling | doaj.art-61a7379b94b44bc09eb3fe358dddd3222022-12-22T03:35:27ZengSAGE PublishingJournal of International Medical Research1473-23002022-11-015010.1177/03000605221134471Distinct clinicopathological features of ovarian endometriosis after long-term exposure to mifepristoneYongmiao PanTingting WuHaiyan ShiObjective Mifepristone has been used to treat endometriosis, but it can cause a constellation of endometrial alterations. Our study investigated the effects of long-term mifepristone on ovarian endometriosis. Methods We retrospectively analyzed the clinicopathological changes of ovarian endometriosis in 11 Chinese patients after long-term low-dose mifepristone therapy and compared these alterations with those observed in eutopic endometrium and adenomyosis side-by-side. Immunohistochemistry was applied to investigate estrogen receptor (ER), progesterone receptor (PR), and Ki67 expression in eutopic and ectopic endometrium. Results Nearly all patients had a pelvic mass and elevated serum CA125 levels. The ovarian lesions were grossly solid, cystic-solid, or cystic. They had a grayish–reddish appearance and a fleshy, honeycomb-like cut surface. The ovarian lesions shared morphological features with the uterine endometrium, and they were characterized by dilated, crowding endometrial glands with non-physiological changes. Immunostaining revealed consistent staining for ER and PR and a low Ki67 index in both eutopic and ectopic endometrium. Conclusions Our findings suggest that ovarian endometriosis can mimic an endometrioid borderline tumor after long-term mifepristone administration. Careful histological assessment and related clinical information are critical for the correct interpretation of these rare entities.https://doi.org/10.1177/03000605221134471 |
| spellingShingle | Yongmiao Pan Tingting Wu Haiyan Shi Distinct clinicopathological features of ovarian endometriosis after long-term exposure to mifepristone Journal of International Medical Research |
| title | Distinct clinicopathological features of ovarian endometriosis after long-term exposure to mifepristone |
| title_full | Distinct clinicopathological features of ovarian endometriosis after long-term exposure to mifepristone |
| title_fullStr | Distinct clinicopathological features of ovarian endometriosis after long-term exposure to mifepristone |
| title_full_unstemmed | Distinct clinicopathological features of ovarian endometriosis after long-term exposure to mifepristone |
| title_short | Distinct clinicopathological features of ovarian endometriosis after long-term exposure to mifepristone |
| title_sort | distinct clinicopathological features of ovarian endometriosis after long term exposure to mifepristone |
| url | https://doi.org/10.1177/03000605221134471 |
| work_keys_str_mv | AT yongmiaopan distinctclinicopathologicalfeaturesofovarianendometriosisafterlongtermexposuretomifepristone AT tingtingwu distinctclinicopathologicalfeaturesofovarianendometriosisafterlongtermexposuretomifepristone AT haiyanshi distinctclinicopathologicalfeaturesofovarianendometriosisafterlongtermexposuretomifepristone |