Global molecular epidemiology and genetic diversity of Fusarium, a significant emerging group of human opportunists from 1958 to 2015
Fusarium is a rapidly emerging, multidrug-resistant genus of fungal opportunists that was first identified in 1958 and is presently recognized in numerous cases of fusariosis each year. The authors examined trends in global Fusarium distribution, clinical presentation and prevalence since 1958 with...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2016-01-01
|
| Series: | Emerging Microbes and Infections |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1038/emi.2016.126 |
| _version_ | 1797679092110196736 |
|---|---|
| author | Abdullah MS Al-Hatmi Ferry Hagen Steph BJ Menken Jacques F Meis G Sybren de Hoog |
| author_facet | Abdullah MS Al-Hatmi Ferry Hagen Steph BJ Menken Jacques F Meis G Sybren de Hoog |
| author_sort | Abdullah MS Al-Hatmi |
| collection | DOAJ |
| description | Fusarium is a rapidly emerging, multidrug-resistant genus of fungal opportunists that was first identified in 1958 and is presently recognized in numerous cases of fusariosis each year. The authors examined trends in global Fusarium distribution, clinical presentation and prevalence since 1958 with the assumption that their distributions in each region had remained unaltered. The phylogeny and epidemiology of 127 geographically diverse isolates, representing 26 Fusarium species, were evaluated using partial sequences of the RPB2 and TEF1 genes, and compared with AFLP fingerprinting data. The molecular data of the Fusarium species were compared with archived data, which enabled the interpretation of hundreds of cases published in the literature. Our findings indicate that fusariosis is globally distributed with a focus in (sub)tropical areas. Considerable species diversity has been observed; genotypic features did not reveal any clustering with either the clinical data or environmental origins. This study suggests that infections with Fusarium species might be truly opportunistic. The three most common species are F. falciforme and F. keratoplasticum (members of F. solani species complex), followed by F. oxysporum (F. oxysporum species complex). |
| first_indexed | 2024-03-11T23:09:24Z |
| format | Article |
| id | doaj.art-61a8ba4190b942a2a16aba5508879f4c |
| institution | Directory Open Access Journal |
| issn | 2222-1751 |
| language | English |
| last_indexed | 2024-03-11T23:09:24Z |
| publishDate | 2016-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Emerging Microbes and Infections |
| spelling | doaj.art-61a8ba4190b942a2a16aba5508879f4c2023-09-21T12:27:55ZengTaylor & Francis GroupEmerging Microbes and Infections2222-17512016-01-015111110.1038/emi.2016.126Global molecular epidemiology and genetic diversity of Fusarium, a significant emerging group of human opportunists from 1958 to 2015Abdullah MS Al-Hatmi0Ferry Hagen1Steph BJ Menken2Jacques F Meis3G Sybren de Hoog4CBS-KNAW Fungal Biodiversity Centre, Department of Medical Mycology, Utrecht 3508 AD, The NetherlandsDepartment of Medical Microbiology and Infectious Diseases, Canisius-Wilhelmina Hospital, Nijmegen 6532 SZ, The NetherlandsInstitutes of Biodiversity and Ecosystem Dynamics, Department of Biology, University of Amsterdam, Amsterdam 1098 XH, The NetherlandsDepartment of Medical Microbiology and Infectious Diseases, Canisius-Wilhelmina Hospital, Nijmegen 6532 SZ, The NetherlandsCBS-KNAW Fungal Biodiversity Centre, Department of Medical Mycology, Utrecht 3508 AD, The NetherlandsFusarium is a rapidly emerging, multidrug-resistant genus of fungal opportunists that was first identified in 1958 and is presently recognized in numerous cases of fusariosis each year. The authors examined trends in global Fusarium distribution, clinical presentation and prevalence since 1958 with the assumption that their distributions in each region had remained unaltered. The phylogeny and epidemiology of 127 geographically diverse isolates, representing 26 Fusarium species, were evaluated using partial sequences of the RPB2 and TEF1 genes, and compared with AFLP fingerprinting data. The molecular data of the Fusarium species were compared with archived data, which enabled the interpretation of hundreds of cases published in the literature. Our findings indicate that fusariosis is globally distributed with a focus in (sub)tropical areas. Considerable species diversity has been observed; genotypic features did not reveal any clustering with either the clinical data or environmental origins. This study suggests that infections with Fusarium species might be truly opportunistic. The three most common species are F. falciforme and F. keratoplasticum (members of F. solani species complex), followed by F. oxysporum (F. oxysporum species complex).https://www.tandfonline.com/doi/10.1038/emi.2016.126AFLPfusariosisFusariumgenotypingmolecular epidemiology |
| spellingShingle | Abdullah MS Al-Hatmi Ferry Hagen Steph BJ Menken Jacques F Meis G Sybren de Hoog Global molecular epidemiology and genetic diversity of Fusarium, a significant emerging group of human opportunists from 1958 to 2015 Emerging Microbes and Infections AFLP fusariosis Fusarium genotyping molecular epidemiology |
| title | Global molecular epidemiology and genetic diversity of Fusarium, a significant emerging group of human opportunists from 1958 to 2015 |
| title_full | Global molecular epidemiology and genetic diversity of Fusarium, a significant emerging group of human opportunists from 1958 to 2015 |
| title_fullStr | Global molecular epidemiology and genetic diversity of Fusarium, a significant emerging group of human opportunists from 1958 to 2015 |
| title_full_unstemmed | Global molecular epidemiology and genetic diversity of Fusarium, a significant emerging group of human opportunists from 1958 to 2015 |
| title_short | Global molecular epidemiology and genetic diversity of Fusarium, a significant emerging group of human opportunists from 1958 to 2015 |
| title_sort | global molecular epidemiology and genetic diversity of fusarium a significant emerging group of human opportunists from 1958 to 2015 |
| topic | AFLP fusariosis Fusarium genotyping molecular epidemiology |
| url | https://www.tandfonline.com/doi/10.1038/emi.2016.126 |
| work_keys_str_mv | AT abdullahmsalhatmi globalmolecularepidemiologyandgeneticdiversityoffusariumasignificantemerginggroupofhumanopportunistsfrom1958to2015 AT ferryhagen globalmolecularepidemiologyandgeneticdiversityoffusariumasignificantemerginggroupofhumanopportunistsfrom1958to2015 AT stephbjmenken globalmolecularepidemiologyandgeneticdiversityoffusariumasignificantemerginggroupofhumanopportunistsfrom1958to2015 AT jacquesfmeis globalmolecularepidemiologyandgeneticdiversityoffusariumasignificantemerginggroupofhumanopportunistsfrom1958to2015 AT gsybrendehoog globalmolecularepidemiologyandgeneticdiversityoffusariumasignificantemerginggroupofhumanopportunistsfrom1958to2015 |