Localisation accuracy with iodine‐125 seed versus wire guidance for breast cancer surgery
Abstract Introduction Impalpable breast lesions generally require image‐guided localisation for breast‐conserving surgery. A standard technique is to place a hook wire (HW) within the lesion. Radioguided occult lesion localisation using iodine seeds (ROLLIS) involves inserting a 4.5 mm iodine‐125 se...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-09-01
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| Series: | Journal of Medical Radiation Sciences |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/jmrs.687 |
| _version_ | 1797686862794457088 |
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| author | Shoba Ratnagobal Donna Taylor Anita G. Bourke Meredith Kessell Carolyn Madeley Melanie C. Robert Philip Vlaskovsky Christobel Saunders |
| author_facet | Shoba Ratnagobal Donna Taylor Anita G. Bourke Meredith Kessell Carolyn Madeley Melanie C. Robert Philip Vlaskovsky Christobel Saunders |
| author_sort | Shoba Ratnagobal |
| collection | DOAJ |
| description | Abstract Introduction Impalpable breast lesions generally require image‐guided localisation for breast‐conserving surgery. A standard technique is to place a hook wire (HW) within the lesion. Radioguided occult lesion localisation using iodine seeds (ROLLIS) involves inserting a 4.5 mm iodine‐125 seed (seed) into the lesion. We hypothesised that a seed could be more precisely positioned in relation to the lesion than a HW and that this may be associated with a lower re‐excision rate. Methods Retrospective review of consecutive participant data from three ROLLIS RCT (ACTRN12613000655741) sites. Participants underwent preoperative lesion localisation (PLL) with seed or HW between September 2013 and December 2017. Lesion and procedural characteristics were recorded. Distances between (1) any part of the seed or thickened segment of the HW (‘TSHW’) and the lesion/clip (‘distance to device’ DTD) and (2) centre of the TSHW/seed and centre of the lesion/clip (device centre to target centre ‘DCTC’) were measured on immediate postinsertion mammograms. Pathological margin involvement and re‐excision rates were compared. Results A total of 390 lesions (190 ROLLIS and 200 HWL) were analysed. Lesion characteristics and guidance modality used were similar between groups. Ultrasound‐guided DTD and DCTC for seed were smaller than for HW (77.1% and 60.6%, respectively, P‐value < 0.001). Stereotactic‐guided DCTC for seeds was 41.6% smaller than for HW (P‐value = 0.001). No statistically significant difference in the re‐excision rates was found. Conclusion Iodine‐125 seeds can be more precisely positioned for preoperative lesion localisation than HW, however, no statistically significant difference in re‐excision rates was detected. |
| first_indexed | 2024-03-12T01:11:47Z |
| format | Article |
| id | doaj.art-61aa05875db54434983814441fbc11e2 |
| institution | Directory Open Access Journal |
| issn | 2051-3895 2051-3909 |
| language | English |
| last_indexed | 2024-03-12T01:11:47Z |
| publishDate | 2023-09-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Medical Radiation Sciences |
| spelling | doaj.art-61aa05875db54434983814441fbc11e22023-09-14T04:47:21ZengWileyJournal of Medical Radiation Sciences2051-38952051-39092023-09-0170321822810.1002/jmrs.687Localisation accuracy with iodine‐125 seed versus wire guidance for breast cancer surgeryShoba Ratnagobal0Donna Taylor1Anita G. Bourke2Meredith Kessell3Carolyn Madeley4Melanie C. Robert5Philip Vlaskovsky6Christobel Saunders7Breast Clinic, Royal Perth Hospital Perth Western Australia AustraliaBreast Clinic, Royal Perth Hospital Perth Western Australia AustraliaBreastScreen WA, Eastpoint Plaza Perth Western Australia AustraliaBreast Clinic, Royal Perth Hospital Perth Western Australia AustraliaBreastScreen WA, Eastpoint Plaza Perth Western Australia AustraliaBreastScreen WA, Eastpoint Plaza Perth Western Australia AustraliaMedical School The University of Western Australia Crawley Western Australia AustraliaBreast Clinic, Royal Perth Hospital Perth Western Australia AustraliaAbstract Introduction Impalpable breast lesions generally require image‐guided localisation for breast‐conserving surgery. A standard technique is to place a hook wire (HW) within the lesion. Radioguided occult lesion localisation using iodine seeds (ROLLIS) involves inserting a 4.5 mm iodine‐125 seed (seed) into the lesion. We hypothesised that a seed could be more precisely positioned in relation to the lesion than a HW and that this may be associated with a lower re‐excision rate. Methods Retrospective review of consecutive participant data from three ROLLIS RCT (ACTRN12613000655741) sites. Participants underwent preoperative lesion localisation (PLL) with seed or HW between September 2013 and December 2017. Lesion and procedural characteristics were recorded. Distances between (1) any part of the seed or thickened segment of the HW (‘TSHW’) and the lesion/clip (‘distance to device’ DTD) and (2) centre of the TSHW/seed and centre of the lesion/clip (device centre to target centre ‘DCTC’) were measured on immediate postinsertion mammograms. Pathological margin involvement and re‐excision rates were compared. Results A total of 390 lesions (190 ROLLIS and 200 HWL) were analysed. Lesion characteristics and guidance modality used were similar between groups. Ultrasound‐guided DTD and DCTC for seed were smaller than for HW (77.1% and 60.6%, respectively, P‐value < 0.001). Stereotactic‐guided DCTC for seeds was 41.6% smaller than for HW (P‐value = 0.001). No statistically significant difference in the re‐excision rates was found. Conclusion Iodine‐125 seeds can be more precisely positioned for preoperative lesion localisation than HW, however, no statistically significant difference in re‐excision rates was detected.https://doi.org/10.1002/jmrs.687Accuracybreastiodine‐125 seedpreoperative localisationROLLIS |
| spellingShingle | Shoba Ratnagobal Donna Taylor Anita G. Bourke Meredith Kessell Carolyn Madeley Melanie C. Robert Philip Vlaskovsky Christobel Saunders Localisation accuracy with iodine‐125 seed versus wire guidance for breast cancer surgery Journal of Medical Radiation Sciences Accuracy breast iodine‐125 seed preoperative localisation ROLLIS |
| title | Localisation accuracy with iodine‐125 seed versus wire guidance for breast cancer surgery |
| title_full | Localisation accuracy with iodine‐125 seed versus wire guidance for breast cancer surgery |
| title_fullStr | Localisation accuracy with iodine‐125 seed versus wire guidance for breast cancer surgery |
| title_full_unstemmed | Localisation accuracy with iodine‐125 seed versus wire guidance for breast cancer surgery |
| title_short | Localisation accuracy with iodine‐125 seed versus wire guidance for breast cancer surgery |
| title_sort | localisation accuracy with iodine 125 seed versus wire guidance for breast cancer surgery |
| topic | Accuracy breast iodine‐125 seed preoperative localisation ROLLIS |
| url | https://doi.org/10.1002/jmrs.687 |
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