Adherence to antihypertensive drug treatment in kidney transplant recipients
Purpose Hypertension is a common cardiovascular co-morbidity after kidney transplantation and contributes to shortened graft and patient survival outcomes. However, by contrast with adherence to immunosuppressive drugs, adherence to antihypertensive treatment in kidney transplant recipients has been...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2021-11-01
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| Series: | Blood Pressure |
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| Online Access: | http://dx.doi.org/10.1080/08037051.2021.2004087 |
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| author | Coralie M. G. Georges Arnaud Devresse Sabrina Ritscher Pierre Wallemacq Stefan W. Toennes Nada Kanaan Alexandre Persu |
| author_facet | Coralie M. G. Georges Arnaud Devresse Sabrina Ritscher Pierre Wallemacq Stefan W. Toennes Nada Kanaan Alexandre Persu |
| author_sort | Coralie M. G. Georges |
| collection | DOAJ |
| description | Purpose Hypertension is a common cardiovascular co-morbidity after kidney transplantation and contributes to shortened graft and patient survival outcomes. However, by contrast with adherence to immunosuppressive drugs, adherence to antihypertensive treatment in kidney transplant recipients has been seldom explored. The aim of the current study was to assess adherence to antihypertensive drugs in kidney transplant recipients from the Cliniques Universitaires Saint-Luc and to look for demographic and clinical characteristics associated with drug adherence. Methods Demographic and clinical data were collected from medical files in a standardised case report form. Blood pressure was measured in the sitting position after 5 min rest, using validated oscillometric devices. Drug adherence was assessed by drug dosage in urine using liquid chromatography coupled with tandem mass spectrometry. Results Our analysis included 53 kidney transplants recipients (75% of men, mean age: 57.2 ± 12.6 years, time since kidney transplantation: 9.5 ± 7.3 years, blood pressure: 130 ± 16/78 ± 11 mmHg on 2.1 ± 1.1 antihypertensive drugs). The proportion of patients showing full drug adherence, partial drug adherence, and total non-adherence to antihypertensive drugs was 79% (N = 42), 15% (N = 8), and 6% (N = 3), respectively. Adherent patients did not differ from less or non- adherers in any of the analysed characteristics. Conclusion The proportion of patients adhering to antihypertensive drug treatment among kidney transplant recipients appears similar to that reported for immunosuppressive drugs in renal transplanted patients (∼70%), but much higher than that observed in patients with drug-resistant hypertension (30–40%). Our results need further confirmation in a large, multicenter, prospective cohort. |
| first_indexed | 2024-03-11T22:35:53Z |
| format | Article |
| id | doaj.art-61aacd28278c4b4580f917494a467119 |
| institution | Directory Open Access Journal |
| issn | 0803-7051 1651-1999 |
| language | English |
| last_indexed | 2024-03-11T22:35:53Z |
| publishDate | 2021-11-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Blood Pressure |
| spelling | doaj.art-61aacd28278c4b4580f917494a4671192023-09-22T13:54:18ZengTaylor & Francis GroupBlood Pressure0803-70511651-19992021-11-0130641141510.1080/08037051.2021.20040872004087Adherence to antihypertensive drug treatment in kidney transplant recipientsCoralie M. G. Georges0Arnaud Devresse1Sabrina Ritscher2Pierre Wallemacq3Stefan W. Toennes4Nada Kanaan5Alexandre Persu6Department of Cardiology, Cliniques Universitaires Saint-Luc, Université Catholique de LouvainInstitut de Recherche Expérimentale et Clinique, Université Catholique de LouvainInstitute of Legal Medicine, Department of Forensic Toxicology, University Hospital, Goethe UniversityInstitut de Recherche Expérimentale et Clinique, Université Catholique de LouvainInstitute of Legal Medicine, Department of Forensic Toxicology, University Hospital, Goethe UniversityInstitut de Recherche Expérimentale et Clinique, Université Catholique de LouvainDepartment of Cardiology, Cliniques Universitaires Saint-Luc, Université Catholique de LouvainPurpose Hypertension is a common cardiovascular co-morbidity after kidney transplantation and contributes to shortened graft and patient survival outcomes. However, by contrast with adherence to immunosuppressive drugs, adherence to antihypertensive treatment in kidney transplant recipients has been seldom explored. The aim of the current study was to assess adherence to antihypertensive drugs in kidney transplant recipients from the Cliniques Universitaires Saint-Luc and to look for demographic and clinical characteristics associated with drug adherence. Methods Demographic and clinical data were collected from medical files in a standardised case report form. Blood pressure was measured in the sitting position after 5 min rest, using validated oscillometric devices. Drug adherence was assessed by drug dosage in urine using liquid chromatography coupled with tandem mass spectrometry. Results Our analysis included 53 kidney transplants recipients (75% of men, mean age: 57.2 ± 12.6 years, time since kidney transplantation: 9.5 ± 7.3 years, blood pressure: 130 ± 16/78 ± 11 mmHg on 2.1 ± 1.1 antihypertensive drugs). The proportion of patients showing full drug adherence, partial drug adherence, and total non-adherence to antihypertensive drugs was 79% (N = 42), 15% (N = 8), and 6% (N = 3), respectively. Adherent patients did not differ from less or non- adherers in any of the analysed characteristics. Conclusion The proportion of patients adhering to antihypertensive drug treatment among kidney transplant recipients appears similar to that reported for immunosuppressive drugs in renal transplanted patients (∼70%), but much higher than that observed in patients with drug-resistant hypertension (30–40%). Our results need further confirmation in a large, multicenter, prospective cohort.http://dx.doi.org/10.1080/08037051.2021.2004087kidney transplantationhypertensiondrug adherenceantihypertensive treatmentlc-ms/ms |
| spellingShingle | Coralie M. G. Georges Arnaud Devresse Sabrina Ritscher Pierre Wallemacq Stefan W. Toennes Nada Kanaan Alexandre Persu Adherence to antihypertensive drug treatment in kidney transplant recipients Blood Pressure kidney transplantation hypertension drug adherence antihypertensive treatment lc-ms/ms |
| title | Adherence to antihypertensive drug treatment in kidney transplant recipients |
| title_full | Adherence to antihypertensive drug treatment in kidney transplant recipients |
| title_fullStr | Adherence to antihypertensive drug treatment in kidney transplant recipients |
| title_full_unstemmed | Adherence to antihypertensive drug treatment in kidney transplant recipients |
| title_short | Adherence to antihypertensive drug treatment in kidney transplant recipients |
| title_sort | adherence to antihypertensive drug treatment in kidney transplant recipients |
| topic | kidney transplantation hypertension drug adherence antihypertensive treatment lc-ms/ms |
| url | http://dx.doi.org/10.1080/08037051.2021.2004087 |
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