Evolution of high-molecular-mass hyaluronic acid is associated with subterranean lifestyle
Abstract Hyaluronic acid is a major component of extracellular matrix which plays an important role in development, cellular response to injury and inflammation, cell migration, and cancer. The naked mole-rat (Heterocephalus glaber) contains abundant high-molecular-mass hyaluronic acid in its tissue...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-12-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-023-43623-2 |
| _version_ | 1797397875435503616 |
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| author | Yang Zhao Zhizhong Zheng Zhihui Zhang Yandong Xu Eric Hillpot Yifei S. Lin Frances T. Zakusilo J. Yuyang Lu Julia Ablaeva Seyed Ali Biashad Richard A. Miller Eviatar Nevo Andrei Seluanov Vera Gorbunova |
| author_facet | Yang Zhao Zhizhong Zheng Zhihui Zhang Yandong Xu Eric Hillpot Yifei S. Lin Frances T. Zakusilo J. Yuyang Lu Julia Ablaeva Seyed Ali Biashad Richard A. Miller Eviatar Nevo Andrei Seluanov Vera Gorbunova |
| author_sort | Yang Zhao |
| collection | DOAJ |
| description | Abstract Hyaluronic acid is a major component of extracellular matrix which plays an important role in development, cellular response to injury and inflammation, cell migration, and cancer. The naked mole-rat (Heterocephalus glaber) contains abundant high-molecular-mass hyaluronic acid in its tissues, which contributes to this species’ cancer resistance and possibly to its longevity. Here we report that abundant high-molecular-mass hyaluronic acid is found in a wide range of subterranean mammalian species, but not in phylogenetically related aboveground species. These subterranean mammalian species accumulate abundant high-molecular-mass hyaluronic acid by regulating the expression of genes involved in hyaluronic acid degradation and synthesis and contain unique mutations in these genes. The abundant high-molecular-mass hyaluronic acid may benefit the adaptation to subterranean environment by increasing skin elasticity and protecting from oxidative stress due to hypoxic conditions. Our work suggests that high-molecular-mass hyaluronic acid has evolved with subterranean lifestyle. |
| first_indexed | 2024-03-09T01:16:33Z |
| format | Article |
| id | doaj.art-61acd860f2a148988e96ad8b36cda67f |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-03-09T01:16:33Z |
| publishDate | 2023-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-61acd860f2a148988e96ad8b36cda67f2023-12-10T12:25:23ZengNature PortfolioNature Communications2041-17232023-12-0114111810.1038/s41467-023-43623-2Evolution of high-molecular-mass hyaluronic acid is associated with subterranean lifestyleYang Zhao0Zhizhong Zheng1Zhihui Zhang2Yandong Xu3Eric Hillpot4Yifei S. Lin5Frances T. Zakusilo6J. Yuyang Lu7Julia Ablaeva8Seyed Ali Biashad9Richard A. Miller10Eviatar Nevo11Andrei Seluanov12Vera Gorbunova13Department of Biology, University of RochesterDepartment of Biology, University of RochesterDepartment of Biology, University of RochesterDepartment of Physiology and Department of Hepatobiliary and Pancreatic Surgery of the First Affiliated Hospital, Zhejiang University School of MedicineDepartment of Biology, University of RochesterDepartment of Biology, University of RochesterDepartment of Biology, University of RochesterDepartment of Biology, University of RochesterDepartment of Biology, University of RochesterDepartment of Biology, University of RochesterDepartment of Pathology, University of Michigan Medical SchoolInstitute of Evolution, University of HaifaDepartment of Biology, University of RochesterDepartment of Biology, University of RochesterAbstract Hyaluronic acid is a major component of extracellular matrix which plays an important role in development, cellular response to injury and inflammation, cell migration, and cancer. The naked mole-rat (Heterocephalus glaber) contains abundant high-molecular-mass hyaluronic acid in its tissues, which contributes to this species’ cancer resistance and possibly to its longevity. Here we report that abundant high-molecular-mass hyaluronic acid is found in a wide range of subterranean mammalian species, but not in phylogenetically related aboveground species. These subterranean mammalian species accumulate abundant high-molecular-mass hyaluronic acid by regulating the expression of genes involved in hyaluronic acid degradation and synthesis and contain unique mutations in these genes. The abundant high-molecular-mass hyaluronic acid may benefit the adaptation to subterranean environment by increasing skin elasticity and protecting from oxidative stress due to hypoxic conditions. Our work suggests that high-molecular-mass hyaluronic acid has evolved with subterranean lifestyle.https://doi.org/10.1038/s41467-023-43623-2 |
| spellingShingle | Yang Zhao Zhizhong Zheng Zhihui Zhang Yandong Xu Eric Hillpot Yifei S. Lin Frances T. Zakusilo J. Yuyang Lu Julia Ablaeva Seyed Ali Biashad Richard A. Miller Eviatar Nevo Andrei Seluanov Vera Gorbunova Evolution of high-molecular-mass hyaluronic acid is associated with subterranean lifestyle Nature Communications |
| title | Evolution of high-molecular-mass hyaluronic acid is associated with subterranean lifestyle |
| title_full | Evolution of high-molecular-mass hyaluronic acid is associated with subterranean lifestyle |
| title_fullStr | Evolution of high-molecular-mass hyaluronic acid is associated with subterranean lifestyle |
| title_full_unstemmed | Evolution of high-molecular-mass hyaluronic acid is associated with subterranean lifestyle |
| title_short | Evolution of high-molecular-mass hyaluronic acid is associated with subterranean lifestyle |
| title_sort | evolution of high molecular mass hyaluronic acid is associated with subterranean lifestyle |
| url | https://doi.org/10.1038/s41467-023-43623-2 |
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