Exploring the mechanisms underlying stroke volume variability reduction in a murine model of heart failure with reduced ejection fraction.
Heart failure with reduced ejection fraction (HFrEF) is accompanied by disregulation of cardiovascular function. Heart rate variability (HRV) is commonly used to assess autonomic dysfunction in HFrEF. However, analysis of stroke volume variability (SVV) may provide additional insights. We examined H...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2023-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0292687&type=printable |
| _version_ | 1797640198577717248 |
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| author | Gemma Fernández-Mendoza Abraham Méndez-Fernández Hugo J Alves-Figueiredo Gerardo García-Rivas Moisés Santillán |
| author_facet | Gemma Fernández-Mendoza Abraham Méndez-Fernández Hugo J Alves-Figueiredo Gerardo García-Rivas Moisés Santillán |
| author_sort | Gemma Fernández-Mendoza |
| collection | DOAJ |
| description | Heart failure with reduced ejection fraction (HFrEF) is accompanied by disregulation of cardiovascular function. Heart rate variability (HRV) is commonly used to assess autonomic dysfunction in HFrEF. However, analysis of stroke volume variability (SVV) may provide additional insights. We examined HRV and SVV in a mouse model of HFrEF. HFrEF mice exhibited reduced stroke volume and ejection fraction versus controls, confirming cardiac contractile dysfunction. HRV was preserved in HFrEF mice. However, SVV was markedly diminished, indicating dissociation between HRV and SVV regulation. Using a mathematical model, we propose that Frank-Starling mechanism abnormalities in HFrEF disrupt SVV independent of HRV. Assessing SVV could thus provide unique insights beyond HRV into cardiovascular control deficits in HFrEF. |
| first_indexed | 2024-03-11T13:28:29Z |
| format | Article |
| id | doaj.art-61aef159235a4688b886a593be03da27 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-03-11T13:28:29Z |
| publishDate | 2023-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-61aef159235a4688b886a593be03da272023-11-03T05:32:51ZengPublic Library of Science (PLoS)PLoS ONE1932-62032023-01-011810e029268710.1371/journal.pone.0292687Exploring the mechanisms underlying stroke volume variability reduction in a murine model of heart failure with reduced ejection fraction.Gemma Fernández-MendozaAbraham Méndez-FernándezHugo J Alves-FigueiredoGerardo García-RivasMoisés SantillánHeart failure with reduced ejection fraction (HFrEF) is accompanied by disregulation of cardiovascular function. Heart rate variability (HRV) is commonly used to assess autonomic dysfunction in HFrEF. However, analysis of stroke volume variability (SVV) may provide additional insights. We examined HRV and SVV in a mouse model of HFrEF. HFrEF mice exhibited reduced stroke volume and ejection fraction versus controls, confirming cardiac contractile dysfunction. HRV was preserved in HFrEF mice. However, SVV was markedly diminished, indicating dissociation between HRV and SVV regulation. Using a mathematical model, we propose that Frank-Starling mechanism abnormalities in HFrEF disrupt SVV independent of HRV. Assessing SVV could thus provide unique insights beyond HRV into cardiovascular control deficits in HFrEF.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0292687&type=printable |
| spellingShingle | Gemma Fernández-Mendoza Abraham Méndez-Fernández Hugo J Alves-Figueiredo Gerardo García-Rivas Moisés Santillán Exploring the mechanisms underlying stroke volume variability reduction in a murine model of heart failure with reduced ejection fraction. PLoS ONE |
| title | Exploring the mechanisms underlying stroke volume variability reduction in a murine model of heart failure with reduced ejection fraction. |
| title_full | Exploring the mechanisms underlying stroke volume variability reduction in a murine model of heart failure with reduced ejection fraction. |
| title_fullStr | Exploring the mechanisms underlying stroke volume variability reduction in a murine model of heart failure with reduced ejection fraction. |
| title_full_unstemmed | Exploring the mechanisms underlying stroke volume variability reduction in a murine model of heart failure with reduced ejection fraction. |
| title_short | Exploring the mechanisms underlying stroke volume variability reduction in a murine model of heart failure with reduced ejection fraction. |
| title_sort | exploring the mechanisms underlying stroke volume variability reduction in a murine model of heart failure with reduced ejection fraction |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0292687&type=printable |
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