Immune Depletion in Combination with Allogeneic Islets Permanently Restores Tolerance to Self-Antigens in Diabetic NOD Mice.

Immune Depletion in Combination with Allogeneic Islets Permanently Restores Tolerance to Self-Antigens in Diabetic NOD Mice.

The destruction of beta cells in type 1 diabetes (T1D) results in loss of insulin production and glucose homeostasis. Treatment of non-obese diabetic (NOD) mice with immune-depleting/modulating agents (e.g., anti-CD3, murine anti-thymocyte-globulin (mATG)) can lead to diabetes reversal. However, for...

Full description

Bibliographic Details
Main Authors:	Nicola Gagliani, Tatiana Jofra, Amanda L Posgai, Mark A Atkinson, Manuela Battaglia
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2015-01-01
Series:	PLoS ONE
Online Access:	http://europepmc.org/articles/PMC4651367?pdf=render

Similar Items

Rapamycin combined with anti-CD45RB mAb and IL-10 or with G-CSF induces tolerance in a stringent mouse model of islet transplantation.
by: Nicola Gagliani, et al.
Published: (2011-01-01)

Preemptive Tolerogenic Delivery of Donor Antigens for Permanent Allogeneic Islet Graft Protection
by: Shusen Wang, et al.
Published: (2015-06-01)

Induction of Allogeneic Islet Tolerance in a Large-Animal Model
by: Peter J. Horton, et al.
Published: (2000-11-01)

Combination of an Antigen-Specific Therapy and an Immunomodulatory Treatment to Simultaneous Block Recurrent Autoimmunity and Alloreactivity in Non-Obese Diabetic Mice.
by: Georgia Fousteri, et al.
Published: (2015-01-01)

NOD2/CARD15 polymorphisms in allogeneic stem-cell transplantation from unrelated donors: T depletion matters - Reply
by: Mayor, N, et al.
Published: (2008)

Neutrophil depletion for early allogeneic islet survival in a methacrylic acid (MAA) copolymer-induced, vascularized subcutaneous space
by: So-Yoon Won, et al.
Published: (2023-10-01)

Tracing the action of IL-2 in tolerance to islet-specific antigen.
by: Liston, A, et al.
Published: (2007)

Distinct Characteristics and Features of Allogeneic Chimerism in the NOD Mouse Model of Autoimmune Diabetes
by: Tatiana D. Zorina M.D., Ph.D., et al.
Published: (2002-03-01)

Co-graft of allogeneic immune regulatory neural stem cells (NPC) and pancreatic islets mediates tolerance, while inducing NPC-derived tumors in mice.
by: Raffaella Melzi, et al.
Published: (2010-04-01)

The Current Status of Allogenic Islet Cell Transplantation
by: Zofia Czarnecka, et al.
Published: (2023-10-01)

Prolonged Allogeneic Islet Graft Survival by Protoporphyrins
by: Antonello Pileggi, et al.
Published: (2005-02-01)

Transient B-cell depletion with anti-CD20 in combination with proinsulin DNA vaccine or oral insulin: immunologic effects and efficacy in NOD mice.
by: Ghanashyam Sarikonda, et al.
Published: (2013-01-01)

2007 Update on Allogeneic Islet Transplantation from the Collaborative Islet Transplant Registry (CITR)
Published: (2009-07-01)

Adverse outcome of human islet-allogeneic blood interaction.
by: Titus, T, et al.
Published: (2003)

Survival of Microencapsulated Islets at 400 Days Posttransplantation in the Omental Pouch of NOD Mice
by: Tsunehiro Kobayashi M.D., Ph.D., et al.
Published: (2006-04-01)

The use of a non-depleting anti-CD4 monoclonal antibody to re-establish tolerance to beta cells in NOD mice.
by: Hutchings, P, et al.
Published: (1992)

The function of NOD2 in antigen presenting cells
by: Allan, P
Published: (2012)

Survival of an Islet Allograft Deficient in iNOS after Implantation into Diabetic NOD Mice
by: Andreas Börjesson, et al.
Published: (2006-09-01)

Long-Term Graft Function after Allogeneic Islet Transplantation
by: Jonathan R. T. Lakey, et al.
Published: (2007-04-01)

Mapping of a hybrid insulin peptide in the inflamed islet β-cells from NOD mice
by: Janet M. Wenzlau, et al.
Published: (2024-02-01)

PEGDA microencapsulated allogeneic islets reverse canine diabetes without immunosuppression
by: Stephen Harrington, et al.
Published: (2022-01-01)

PEGDA microencapsulated allogeneic islets reverse canine diabetes without immunosuppression.
by: Stephen Harrington, et al.
Published: (2022-01-01)

T cell depletion with CAMPATH-1 in allogeneic bone marrow transplantation.
by: Hale, G, et al.
Published: (1988)

Insulin-Induced Normoglycemia Reduces Islet Number Needed to Achieve Normoglycemia after Allogeneic Islet Transplantation in Diabetic Mice
by: Juan C. Ferrer-Garcia, et al.
Published: (2003-11-01)

Metabolic effect of low fluoride levels in the islets of NOD mice: integrative morphological, immunohistochemical, and proteomic analyses
by: Juliana Sanches TREVIZOL, et al.
Published: (2023-06-01)

CTLA4-Ig Prolongs Survival of Microencapsulated Neonatal Porcine Islet Xenografts in Diabetic Nod Mice
by: Collin J. Weber M.D., D.M.Sci, et al.
Published: (1997-09-01)

Substantial peripheral T-cell depletion before grafting is beneficial in islet transplantation.
by: Brons, I, et al.
Published: (1995)

Vaccination with single chain antigen receptors for islet-derived peptides presented on I-A(g7) delays diabetes in NOD mice by inducing anergy in self-reactiveT-cells.
by: Werner Gurr, et al.
Published: (2013-01-01)

Immune reconstitution following allogeneic bone marrow transplantation depleted of T-cells.
by: Davison, G, et al.
Published: (1998)

Immune reconstitution after allogeneic bone marrow transplantation depleted of T cells.
by: Davison, G, et al.
Published: (2000)

Immune reconstitution post T-CELL depleted allogeneic bone marrow transplantation
by: Davison, G, et al.
Published: (1998)

Induction of Immunological Tolerance to Islet Allografts
by: Aldo A. Rossini M.D., et al.
Published: (1996-01-01)

Tolerance to Proinsulin-1 Reduces Autoimmune Diabetes in NOD Mice
by: Gaurang Jhala, et al.
Published: (2021-03-01)

Allogeneic islet transplantation with monitoring of islet‐specific cellular autoimmunity in a Japanese patient with type 1 diabetes: A case report
by: Daisuke Chujo, et al.
Published: (2022-04-01)

Selective Depletion of Cross-Presenting Dendritic Cells Enhances Islet Allograft Survival
by: Robyn M. Sutherland, et al.
Published: (2011-04-01)

Optimal allogeneic islet dose for transplantation in insulin-dependent diabetic Macaca fascicularis monkeys
by: Geun Soo Kim, et al.
Published: (2021-04-01)

Hepatic Cells via Cava Vein Can Influence Allogenic Islet Rat Transplantation
by: Antonino Jara-Albarrán, et al.
Published: (2003-11-01)

Outcome following T-cell depletion of allogeneic peripheral blood progenitor cells for transplantation
by: Novitzky, N, et al.
Published: (1997)

Tumor vaccine strategies after allogeneic T-cell depleted bone marrow transplantation
by: Ferrara James L.M.
Published: (2002-01-01)

Lixisenatide accelerates restoration of normoglycemia and improves human beta-cell function and survival in diabetic immunodeficient NOD–scid IL-2rgnull RIP-DTR mice engrafted with human islets
by: Yang C, et al.
Published: (2015-08-01)