Endoscopic Ultrasound-Guided Sampling for Personalized Pancreatic Cancer Treatment
Pancreatic cancer is the most lethal solid malignancy, and the number of patients with pancreatic cancer is increasing. Systemic chemotherapies are often ineffective for such patients, and there is an urgent need for personalized medicine. Unlike other types of cancer, personalized treatments for pa...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-03-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/11/3/469 |
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| author | Eisuke Iwasaki Seiichiro Fukuhara Masayasu Horibe Shintaro Kawasaki Takashi Seino Yoichi Takimoto Hiroki Tamagawa Yujiro Machida Atsuto Kayashima Marin Noda Hideyuki Hayashi Takanori Kanai |
| author_facet | Eisuke Iwasaki Seiichiro Fukuhara Masayasu Horibe Shintaro Kawasaki Takashi Seino Yoichi Takimoto Hiroki Tamagawa Yujiro Machida Atsuto Kayashima Marin Noda Hideyuki Hayashi Takanori Kanai |
| author_sort | Eisuke Iwasaki |
| collection | DOAJ |
| description | Pancreatic cancer is the most lethal solid malignancy, and the number of patients with pancreatic cancer is increasing. Systemic chemotherapies are often ineffective for such patients, and there is an urgent need for personalized medicine. Unlike other types of cancer, personalized treatments for pancreatic cancer are still in development. Consequently, pancreatic cancer is less sensitive to anticancer drugs and is often refractory to common treatments. Therefore, advances in personalized medicine for pancreatic cancer are necessary. This review examined advances in personalized medicine for pancreatic cancer, including the use of endoscopic ultrasound (EUS)-guided sampling. EUS-guided sampling is widely used for diagnosing pancreatic tumors and is expected to be applied to sampled tissues. Additionally, there has been an increase in clinical research using EUS-guided sampling. The combination of precision medicine using genomic testing and pharmacological profiles based on high-throughput drug sensitivity testing using patient-derived organoids is expected to revolutionize pancreatic cancer treatment. |
| first_indexed | 2024-03-09T05:03:58Z |
| format | Article |
| id | doaj.art-61af74135de04588859bf7f3fec58e2e |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-09T05:03:58Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-61af74135de04588859bf7f3fec58e2e2023-12-03T12:57:08ZengMDPI AGDiagnostics2075-44182021-03-0111346910.3390/diagnostics11030469Endoscopic Ultrasound-Guided Sampling for Personalized Pancreatic Cancer TreatmentEisuke Iwasaki0Seiichiro Fukuhara1Masayasu Horibe2Shintaro Kawasaki3Takashi Seino4Yoichi Takimoto5Hiroki Tamagawa6Yujiro Machida7Atsuto Kayashima8Marin Noda9Hideyuki Hayashi10Takanori Kanai11Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine 35, Shinanomachi, Shinjuku-ku, Tokyo 160-8582, JapanCenter for Diagnostic and Therapeutic Endoscopy, Keio University School of Medicine 35, Shinanomachi, Shinjuku-ku, Tokyo 160-8582, JapanDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine 35, Shinanomachi, Shinjuku-ku, Tokyo 160-8582, JapanDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine 35, Shinanomachi, Shinjuku-ku, Tokyo 160-8582, JapanDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine 35, Shinanomachi, Shinjuku-ku, Tokyo 160-8582, JapanDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine 35, Shinanomachi, Shinjuku-ku, Tokyo 160-8582, JapanDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine 35, Shinanomachi, Shinjuku-ku, Tokyo 160-8582, JapanDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine 35, Shinanomachi, Shinjuku-ku, Tokyo 160-8582, JapanDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine 35, Shinanomachi, Shinjuku-ku, Tokyo 160-8582, JapanDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine 35, Shinanomachi, Shinjuku-ku, Tokyo 160-8582, JapanKeio Cancer Center, Genomic Units, Keio University School of Medicine 35, Shinanomachi, Shinjuku-ku, Tokyo 160-8582, JapanDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine 35, Shinanomachi, Shinjuku-ku, Tokyo 160-8582, JapanPancreatic cancer is the most lethal solid malignancy, and the number of patients with pancreatic cancer is increasing. Systemic chemotherapies are often ineffective for such patients, and there is an urgent need for personalized medicine. Unlike other types of cancer, personalized treatments for pancreatic cancer are still in development. Consequently, pancreatic cancer is less sensitive to anticancer drugs and is often refractory to common treatments. Therefore, advances in personalized medicine for pancreatic cancer are necessary. This review examined advances in personalized medicine for pancreatic cancer, including the use of endoscopic ultrasound (EUS)-guided sampling. EUS-guided sampling is widely used for diagnosing pancreatic tumors and is expected to be applied to sampled tissues. Additionally, there has been an increase in clinical research using EUS-guided sampling. The combination of precision medicine using genomic testing and pharmacological profiles based on high-throughput drug sensitivity testing using patient-derived organoids is expected to revolutionize pancreatic cancer treatment.https://www.mdpi.com/2075-4418/11/3/469EUS-guided samplingpancreatic cancerpatient-derived organoidprecision medicine |
| spellingShingle | Eisuke Iwasaki Seiichiro Fukuhara Masayasu Horibe Shintaro Kawasaki Takashi Seino Yoichi Takimoto Hiroki Tamagawa Yujiro Machida Atsuto Kayashima Marin Noda Hideyuki Hayashi Takanori Kanai Endoscopic Ultrasound-Guided Sampling for Personalized Pancreatic Cancer Treatment Diagnostics EUS-guided sampling pancreatic cancer patient-derived organoid precision medicine |
| title | Endoscopic Ultrasound-Guided Sampling for Personalized Pancreatic Cancer Treatment |
| title_full | Endoscopic Ultrasound-Guided Sampling for Personalized Pancreatic Cancer Treatment |
| title_fullStr | Endoscopic Ultrasound-Guided Sampling for Personalized Pancreatic Cancer Treatment |
| title_full_unstemmed | Endoscopic Ultrasound-Guided Sampling for Personalized Pancreatic Cancer Treatment |
| title_short | Endoscopic Ultrasound-Guided Sampling for Personalized Pancreatic Cancer Treatment |
| title_sort | endoscopic ultrasound guided sampling for personalized pancreatic cancer treatment |
| topic | EUS-guided sampling pancreatic cancer patient-derived organoid precision medicine |
| url | https://www.mdpi.com/2075-4418/11/3/469 |
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