Nasal Blockage Induced by Oral Administration of Non-steroidal Anti-inflammatory Drugs in a Guinea-Pig Model of Allergic Rhinitis
To elucidate the mechanisms underlying nasal symptoms in patients with aspirin hypersensitivity, we evaluated the effects of orally administered non-steroidal anti-inflammatory drugs (NSAIDs) on the nasal patency of guinea pigs with cedar pollen–induced chronic allergic rhinitis. Indomethacin (10 mg...
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| Format: | Article |
| Language: | English |
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Elsevier
2007-01-01
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| Series: | Journal of Pharmacological Sciences |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1347861319341891 |
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| author | Hai Yan Han Takeshi Nabe Nobuaki Mizutani Masanori Fujii Tetsuya Terada Hiroshi Takenaka Shigekatsu Kohno |
| author_facet | Hai Yan Han Takeshi Nabe Nobuaki Mizutani Masanori Fujii Tetsuya Terada Hiroshi Takenaka Shigekatsu Kohno |
| author_sort | Hai Yan Han |
| collection | DOAJ |
| description | To elucidate the mechanisms underlying nasal symptoms in patients with aspirin hypersensitivity, we evaluated the effects of orally administered non-steroidal anti-inflammatory drugs (NSAIDs) on the nasal patency of guinea pigs with cedar pollen–induced chronic allergic rhinitis. Indomethacin (10 mg/kg) administered 1 h before a pollen challenge amplified the antigen-induced nasal blockage. More interestingly, even in the absence of the pollen challenge, indomethacin induced nasal blockage at 30 min at 4 h after administration. However, indomethacin-induced nasal blockage was not provoked in non-sensitized animals. Another NSAID, diclofenac (30 mg/kg), also evoked nasal blockage, but unexpectedly, aspirin (500 mg/kg) did not affect nasal patency. Indomethacin-induced nasal blockage was unaffected by a cysteinyl leukotriene receptor (CysLT1 receptor) antagonist, pranlukast (30 mg/kg, p.o.), or by prostaglandin E2 (10− M, intranasal), suggesting that the nasal blockage may not be due to hyperproduction of cysteinyl leukotrienes or inhibition of prostaglandin E2 production. These results indicate that the indomethacin-induced nasal blockage may not be an identical phenomena to airway symptoms in aspirin hypersensitivity patients. However, because chronic nasal inflammation is indispensable for the development of nasal blockage, indomethacin-induced nasal blockage may become a clue to elucidate new mechanisms underlying hypersensitivity to NSAIDs. Keywords:: nasal blockage, indomethacin, aspirin, cysteinyl leukotriene, prostaglandin E2 |
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| format | Article |
| id | doaj.art-61af8e9e15fb4a9690a377e26824d732 |
| institution | Directory Open Access Journal |
| issn | 1347-8613 |
| language | English |
| last_indexed | 2024-12-14T00:05:54Z |
| publishDate | 2007-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Pharmacological Sciences |
| spelling | doaj.art-61af8e9e15fb4a9690a377e26824d7322022-12-21T23:26:02ZengElsevierJournal of Pharmacological Sciences1347-86132007-01-011053251257Nasal Blockage Induced by Oral Administration of Non-steroidal Anti-inflammatory Drugs in a Guinea-Pig Model of Allergic RhinitisHai Yan Han0Takeshi Nabe1Nobuaki Mizutani2Masanori Fujii3Tetsuya Terada4Hiroshi Takenaka5Shigekatsu Kohno6Department of Pharmacology, Kyoto Pharmaceutical University, 5 Nakauchi, Misasagi, Yamashina, Kyoto 607-8414, JapanDepartment of Pharmacology, Kyoto Pharmaceutical University, 5 Nakauchi, Misasagi, Yamashina, Kyoto 607-8414, Japan; Corresponding author. nabe@mb.kyoto-phu.ac.jpDepartment of Pharmacology, Kyoto Pharmaceutical University, 5 Nakauchi, Misasagi, Yamashina, Kyoto 607-8414, JapanDepartment of Pharmacology, Kyoto Pharmaceutical University, 5 Nakauchi, Misasagi, Yamashina, Kyoto 607-8414, JapanDepartment of Otorhinolaryngology, Osaka Medical College, 2-7 Daigaku-cho, Takatsuki, Osaka 569-8686, JapanDepartment of Otorhinolaryngology, Osaka Medical College, 2-7 Daigaku-cho, Takatsuki, Osaka 569-8686, JapanDepartment of Pharmacology, Kyoto Pharmaceutical University, 5 Nakauchi, Misasagi, Yamashina, Kyoto 607-8414, JapanTo elucidate the mechanisms underlying nasal symptoms in patients with aspirin hypersensitivity, we evaluated the effects of orally administered non-steroidal anti-inflammatory drugs (NSAIDs) on the nasal patency of guinea pigs with cedar pollen–induced chronic allergic rhinitis. Indomethacin (10 mg/kg) administered 1 h before a pollen challenge amplified the antigen-induced nasal blockage. More interestingly, even in the absence of the pollen challenge, indomethacin induced nasal blockage at 30 min at 4 h after administration. However, indomethacin-induced nasal blockage was not provoked in non-sensitized animals. Another NSAID, diclofenac (30 mg/kg), also evoked nasal blockage, but unexpectedly, aspirin (500 mg/kg) did not affect nasal patency. Indomethacin-induced nasal blockage was unaffected by a cysteinyl leukotriene receptor (CysLT1 receptor) antagonist, pranlukast (30 mg/kg, p.o.), or by prostaglandin E2 (10− M, intranasal), suggesting that the nasal blockage may not be due to hyperproduction of cysteinyl leukotrienes or inhibition of prostaglandin E2 production. These results indicate that the indomethacin-induced nasal blockage may not be an identical phenomena to airway symptoms in aspirin hypersensitivity patients. However, because chronic nasal inflammation is indispensable for the development of nasal blockage, indomethacin-induced nasal blockage may become a clue to elucidate new mechanisms underlying hypersensitivity to NSAIDs. Keywords:: nasal blockage, indomethacin, aspirin, cysteinyl leukotriene, prostaglandin E2http://www.sciencedirect.com/science/article/pii/S1347861319341891 |
| spellingShingle | Hai Yan Han Takeshi Nabe Nobuaki Mizutani Masanori Fujii Tetsuya Terada Hiroshi Takenaka Shigekatsu Kohno Nasal Blockage Induced by Oral Administration of Non-steroidal Anti-inflammatory Drugs in a Guinea-Pig Model of Allergic Rhinitis Journal of Pharmacological Sciences |
| title | Nasal Blockage Induced by Oral Administration of Non-steroidal Anti-inflammatory Drugs in a Guinea-Pig Model of Allergic Rhinitis |
| title_full | Nasal Blockage Induced by Oral Administration of Non-steroidal Anti-inflammatory Drugs in a Guinea-Pig Model of Allergic Rhinitis |
| title_fullStr | Nasal Blockage Induced by Oral Administration of Non-steroidal Anti-inflammatory Drugs in a Guinea-Pig Model of Allergic Rhinitis |
| title_full_unstemmed | Nasal Blockage Induced by Oral Administration of Non-steroidal Anti-inflammatory Drugs in a Guinea-Pig Model of Allergic Rhinitis |
| title_short | Nasal Blockage Induced by Oral Administration of Non-steroidal Anti-inflammatory Drugs in a Guinea-Pig Model of Allergic Rhinitis |
| title_sort | nasal blockage induced by oral administration of non steroidal anti inflammatory drugs in a guinea pig model of allergic rhinitis |
| url | http://www.sciencedirect.com/science/article/pii/S1347861319341891 |
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